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How to get fromMadrid to Santa Anaby bus, train, or car

Find Transport to Santa Ana

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There are 4 ways to get from Madrid to Santa Ana by bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus via Trujillo

    best
    1. Take the bus from Madrid Estación Sur de Autobuses to Trujillobus bus
    4h 38m
    €29–49

  2. Train, bus

    1. Take the train from Madrid-Puerta de Atocha-Almudena Grandes to Cacerestrain train Alv / ...
    2. Take the bus from Cáceres to Santa Anabus bus
    5h 18m
    €47–68

  3. Drive 277 km

    1. Drive from Madrid to Santa Anacar car 277 km
    2h 54m
    €44–63

  4. Bus

    1. Take the bus from Estación Sur de Autobuses to Trujillobus bus Auto Res
    5h 30m
    €37–54

Questions & Answers

Map of how to get from Madrid to Santa Ana.ExpandLaunch map view
  • Distance: 290.4 km
  • Duration: 4h 38m

What companies run services between Madrid, Spain and Santa Ana, Extremadura, Spain?

Interbus operates a bus from Madrid Estación Sur de Autobuses to Trujillo 4 times a week. Tickets cost €26–50 and the journey takes 3h 5m.

Train operators
Bus operators

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