There are 2 ways to get from Madrid to Santa Cruz by plane or train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly from Adolfo Suárez Madrid–Barajas Airport
best- Fly from Adolfo Suárez Madrid–Barajas Airport (MAD) to Viru Viru International Airport (VVI)plane MAD - VVI
13h 50m$452–1,203Train to Valencia Airport, fly
- Take the train from Madrid Chamartín to Valencia Joaquin Sorollatrain
- Fly from Valencia Airport (VLC) to Viru Viru International Airport (VVI)plane VLC - VVI
20h 41m$468–1,412
Adolfo Suárez Madrid–Barajas Airport (MAD) to Viru Viru International Airport (VVI) flights
Comparing Your Travel Options
The cheapest way to get from Madrid to Santa Cruz is to fly which costs $450 - $1,200 and takes 13h 50m.
The fastest way to get from Madrid to Santa Cruz is to fly which takes 13h 50m and costs $450 - $1,200.
The distance between Madrid and Santa Cruz is 8946 km.
It takes approximately 13h 50m to get from Madrid to Santa Cruz, including transfers.
Santa Cruz is 5h behind Madrid. It is currently 9:11 PM in Madrid and 4:11 PM in Santa Cruz.
There are 752+ hotels available in Santa Cruz.
What companies run services between Madrid, Spain and Santa Cruz, Bolivia?
Boliviana de Aviación and Air Europa fly from Adolfo Suárez Madrid–Barajas Airport (MAD) to Viru Viru International Airport (VVI) twice daily.
- Website
- boa.bo
Flights from Adolfo Suárez Madrid–Barajas Airport to Viru Viru International Airport
- Ave. Duration
- 11h
- When
- Monday, Tuesday, Wednesday, Friday, and Sunday
- Estimated price
- $460–850
Flights from Adolfo Suárez Madrid–Barajas Airport to Viru Viru International Airport via Cochabamba
- Ave. Duration
- 17h 35m
- When
- Tuesday
- Estimated price
- $460–850
Flights from Valencia Airport to Viru Viru International Airport via Adolfo Suárez Madrid–Barajas Airport, Cochabamba
- Ave. Duration
- 15h 50m
- When
- Tuesday
- Estimated price
- $550–1,500
- Website
- aireuropa.com
Flights from Adolfo Suárez Madrid–Barajas Airport to Viru Viru International Airport
- Ave. Duration
- 11h 20m
- When
- Monday, Wednesday, and Saturday
- Estimated price
- $380–1,200
Flights from Valencia Airport to Viru Viru International Airport via Adolfo Suárez Madrid–Barajas Airport
- Ave. Duration
- 19h 10m
- When
- Tuesday, Friday, and Sunday
- Estimated price
- $430–1,300
- Website
- iberia.com
Flights from Adolfo Suárez Madrid–Barajas Airport to Viru Viru International Airport
- Ave. Duration
- 11h
- When
- Monday, Tuesday, Wednesday, Friday, and Sunday
- Estimated price
- $460–850
Flights from Valencia Airport to Viru Viru International Airport via Adolfo Suárez Madrid–Barajas Airport
- Ave. Duration
- 15h 30m
- When
- Monday, Tuesday, Wednesday, Friday, and Sunday
- Estimated price
- $550–1,500
- Phone
- +34 91 232 03 20
- Website
- Renfe AVE
Train from Madrid Chamartín to Valencia Joaquin Sorolla
- Ave. Duration
- 2h 4m
- Frequency
- Hourly
- Estimated price
- $55–110
- Website
- Renfe AVE
- Phone
- +34 900 926 851
- [email protected]
- Website
- Iryo
Train from Madrid Chamartín to Valencia Joaquin Sorolla
- Ave. Duration
- 2h
- Frequency
- Hourly
- Estimated price
- $40–70
- Website
- Iryo
- Phone
- +34 900 759 781
- Website
- Ouigo
Train from Madrid Chamartín to Valencia Joaquin Sorolla
- Ave. Duration
- 2h 1m
- Frequency
- Every 3 hours
- Estimated price
- $30–55
- Website
- Ouigo
- Phone
- +34 91 232 03 20
- Website
- Renfe Viajeros
Train from Madrid Chamartín to Valencia Joaquin Sorolla
- Ave. Duration
- 2h 4m
- Frequency
- 5 times a day
- Estimated price
- $55–80
- Website
- Renfe Viajeros
Want to know more about travelling around Bolivia
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Train travel in Spain: A guide to Renfe
Read the travel guide
What are the different types of Renfe trains in Spain?
Read the travel guide

















