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How to get fromMaine to Buffaloby plane, bus (Amtrak, Greyhound), bus, train, car, bus (Amtrak, Flixbus), or train (Amtrak)

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There are 7 ways to get from Maine to Buffalo by plane, bus (Amtrak, Greyhound), bus, train, car, bus (Amtrak, Flixbus), or train (Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Portland

    best
    1. Fly from Portland (PWM) to Buffalo Niagara International Airport (BUF)plane plane PWM - BUF
    5h
    $129–731

  2. Drive  509.9 mi

    cheapest
    1. Drive from Portland to Buffalocar car 509.9 mi
    10h 22m
    $93–135

  3. Bus

    1. Take the bus from Portland, ME to Boston, MA - South Stationbus bus Portland / ...
    2. Take the bus from Boston to Buffalobus bus Greyhound US0171
    13h 37m
    $108–179

  4. Bus, train

    1. Take the bus from Portland, ME to Boston, MA - South Stationbus bus Portland / ...
    2. Take the train from Boston to Buffalo Depew Stationtrain train Lake Shore Limited
    16h 32m
    $285–609

  5. Bus to Boston Logan Airport, fly

    1. Take the bus from Portland, ME to Logan International Airportbus bus
    2. Fly from Boston Logan Airport (BOS) to Buffalo Niagara International Airport (BUF)plane plane BOS - BUF
    6h 37m
    $125–717

  6. Bus via Ithaca

    1. Take the bus from Portland, ME to Boston, MA - South Stationbus bus
    2. Take the bus from Boston to Ithacabus bus
    3. Take the bus from Ithaca to Buffalobus bus
    16h 6m
    $109–179

  7. Train (Amtrak)

    1. Take the train from Portland to Bostontrain train Downeaster
    2. Take the train from Boston to Buffalo Depew Stationtrain train Lake Shore Limited
    18h 15m
    $329–531

Maine to Buffalo by bus

Calendar7Weekly Buses
Duration13h 37mAverage Duration
Ticket$108Cheapest Price
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Comparing Your Travel Options

Map of how to get from Maine to Buffalo.ExpandLaunch map view
  • Distance: 435.9 mi
  • Duration: 5h

What companies run services between Maine, USA and Buffalo, NY, USA?

Southwest Airlines, American Airlines, and two other airlines fly from Portland (PWM) to Buffalo Niagara International Airport (BUF) every 2 hours. Alternatively, you can take a bus from Portland Public Library to Buffalo via Portland, ME, Boston, MA - South Station, and Boston in around 13h 37m.

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Want to know more about travelling around United States

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Need to know: Greyhound

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