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How to get fromMaine to Knoxvilleby plane, bus, train, car, bus (Amtrak, Greyhound), or bus (Amtrak, Flixbus)

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There are 8 ways to get from Maine to Knoxville by plane, bus, train, car, bus (Amtrak, Greyhound), or bus (Amtrak, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Portland to Mcghee Tyson Airport

    best
    1. Fly from Portland (PWM) to Mcghee Tyson Airport (TYS)plane plane PWM - TYS
    4h 32m
    $257–1,013

  2. Fly Portland to Nashville, drive

    cheapest
    1. Fly from Portland (PWM) to Nashville (BNA)plane plane PWM - BNA
    2. Drive from Nashville-Airport-BNA to Knoxvillecar car
    5h 29m
    $160–643

  3. Bus, train

    1. Take the bus from Portland, ME to Boston, MA - South Stationbus bus
    2. Take the train from Boston to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    20h 54m
    $211–962

  4. Drive 1,008.8 mi

    1. Drive from Portland to Knoxvillecar car 1,008.8 mi
    17h 40m
    $185–266

  5. Fly Bangor to Mcghee Tyson Airport

    1. Fly from Bangor (BGR) to Mcghee Tyson Airport (TYS)plane plane BGR - TYS
    6h 8m
    $326–1,372

  6. Bus via New York

    1. Take the bus from Portland, ME to Boston, MA - South Stationbus bus
    2. Take the bus from Boston to Port Authority Bus Terminalbus bus
    3. Take the bus from New York to Knoxvillebus bus Nyc
    21h 30m
    $236–367

  7. Bus

    1. Take the bus from Portland, ME to Boston, MA - South Stationbus bus
    2. Take the bus from Boston to NYC Downtownbus bus
    3. Take the bus from New York to Knoxvillebus bus Nyc
    21h 38m
    $233–359

  8. Train, bus

    1. Take the train from Portland to Bostontrain train
    2. Take the train from Boston to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York to Knoxvillebus bus Nyc
    22h 14m
    $273–1,090

Portland (PWM) to Mcghee Tyson Airport (TYS) flights

Calendar71Weekly Planes
Duration5h 19mAverage Duration
Ticket$201Cheapest Price
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Questions & Answers

Map of how to get from Maine to Knoxville.ExpandLaunch map view
  • Distance: 917.5 mi
  • Duration: 4h 32m

What companies run services between Maine, USA and Knoxville, TN, USA?

Southwest Airlines, Delta, and two other airlines fly from Portland (PWM) to Mcghee Tyson Airport (TYS) every 3 hours. Alternatively, you can take a bus from Portland Public Library to Knoxville via Portland, ME, Boston, MA - South Station, Boston, Port Authority Bus Terminal, 34 St-Herald Sq, East Broadway, New York, and Knoxville in around 21h 30m.

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