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How to get fromMaine to La Crosseby plane, bus, train, bus (Amtrak, Flixbus, Greyhound), or car

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There are 7 ways to get from Maine to La Crosse by plane, bus, train, bus (Amtrak, Flixbus, Greyhound), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Portland to La Crosse

    best
    1. Fly from Portland (PWM) to La Crosse (LSE)plane plane PWM - LSE
    5h 53m
    $147–591

  2. Bus, train

    1. Take the bus from Portland, ME to Boston, MA - South Stationbus bus
    2. Take the train from Boston to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to La Crosse Amtrak Stationtrain train
    31h 54m
    $443–939

  3. Bus

    1. Take the bus from Portland, ME to Boston, MA - South Stationbus bus
    2. Take the bus from Boston to New York Midtownbus bus
    3. Take the bus from New York Midtown to Chicago Bus Stationbus bus
    4. Take the bus from Chicago Bus Station to Milwaukee Intermodal Stationbus bus
    5. Take the bus from Milwaukee to La Crossebus bus
    32h 34m
    $266–465

  4. Drive 1,317.8 mi

    1. Drive from Portland to La Crossecar car 1,317.8 mi
    23h 56m
    $241–348

  5. Fly Bangor to La Crosse

    1. Fly from Bangor (BGR) to La Crosse (LSE)plane plane BGR - LSE
    7h 50m
    $180–774

  6. Fly Portland to Minneapolis–Saint Paul International Airport, train

    1. Fly from Portland (PWM) to Minneapolis–Saint Paul International Airport (MSP)plane plane PWM - MSP
    2. Take the train from St. Paul-Minneapolis to La Crosse Amtrak Stationtrain train
    7h 28m
    $201–792

  7. Fly Portland to Rochester, bus

    1. Fly from Portland (PWM) to Rochester (RST)plane plane PWM - RST
    2. Take the bus from Rochester, MN to La Crossebus bus
    9h 4m
    $160–621

Maine to La Crosse by bus and train

Calendar7Weekly Services
Duration31h 54mAverage Duration
Ticket$443Cheapest Price
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Questions & Answers

Map of how to get from Maine to La Crosse.ExpandLaunch map view
  • Distance: 1,050.4 mi
  • Duration: 5h 53m

What companies run services between Maine, USA and La Crosse, WI, USA?

American Airlines and United Airlines fly from Portland (PWM) to La Crosse (LSE) every 4 hours. Alternatively, you can take a bus from Portland Public Library to La Crosse via Portland, ME, Boston, MA - South Station, Boston, New York Midtown, Chicago Bus Station, Milwaukee Intermodal Station, and Milwaukee in around 32h 34m.

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