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How to get fromMaine to Mayo Clinicby plane, bus (Amtrak, Flixbus, Greyhound), bus, train, or car

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There are 7 ways to get from Maine to Mayo Clinic by plane, bus (Amtrak, Flixbus, Greyhound), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Portland to Rochester

    best
    1. Fly from Portland (PWM) to Rochester (RST)plane plane PWM - RST
    6h 37m
    $130–600

  2. Bus

    1. Take the bus from Portland, ME to Boston, MA - South Stationbus bus
    2. Take the bus from Boston to New York Midtownbus bus
    3. Take the bus from New York Midtown to Chicago Bus Stationbus bus
    4. Take the bus from Chicago Bus Station to Milwaukee Intermodal Stationbus bus
    5. Take the bus from Milwaukee to Rochesterbus bus
    34h 42m
    $277–476

  3. Bus, train

    1. Take the bus from Portland, ME to Boston, MA - South Stationbus bus
    2. Take the train from Boston to Chicago Union Stationtrain train
    3. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    4. Take the bus from Madison to Rochesterbus bus
    35h 39m
    $428–879

  4. Drive 1,382.9 mi

    1. Drive from Portland to Mayo Cliniccar car 1,382.9 mi
    24h 59m
    $253–365

  5. Fly Portland to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Portland (PWM) to Minneapolis–Saint Paul International Airport (MSP)plane plane PWM - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    5h 53m
    $211–756

  6. Fly Bangor to Rochester

    1. Fly from Bangor (BGR) to Rochester (RST)plane plane BGR - RST
    8h 42m
    $172–752

  7. Train, bus

    1. Take the train from Portland to Bostontrain train
    2. Take the train from Boston to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    4. Take the bus from St. Paul to Rochester, MNbus bus
    38h 25m
    $528–1,097

Maine to Mayo Clinic by bus, train, subway, and foot

Calendar7Weekly Services
Duration38h 25mAverage Duration
Ticket$528Cheapest Price
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Questions & Answers

Map of how to get from Maine to Mayo Clinic.ExpandLaunch map view
  • Distance: 1,112.7 mi
  • Duration: 6h 37m

What companies run services between Maine, USA and Mayo Clinic, MN, USA?

Delta, American Airlines, and United Airlines fly from Portland (PWM) to Rochester (RST) 5 times a day. Alternatively, you can take a bus from Portland Public Library to Mayo Clinic via Portland, ME, Boston, MA - South Station, Boston, New York Midtown, Chicago Bus Station, Milwaukee Intermodal Station, Milwaukee, and Rochester in around 34h 42m.

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