Rome2Rio

How to get fromMaine to St. Louisby plane, bus, train, bus (Amtrak, Greyhound), car, or bus (Amtrak, Greyhound, Flixbus)

Find Transport to St. Louis

See all options

There are 5 ways to get from Maine to St. Louis by plane, bus, train, bus (Amtrak, Greyhound), car, or bus (Amtrak, Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Portland (PWM) to Lambert–St. Louis International Airport (STL)plane plane PWM - STL
    5h 28m
    $165–785

  2. Bus, train

    1. Take the bus from Portland, ME to Boston, MA - South Stationbus bus
    2. Take the train from Boston to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Louistrain train
    31h 40m
    $723–1,189

  3. Bus via New York

    1. Take the bus from Portland, ME to Boston, MA - South Stationbus bus
    2. Take the bus from Boston to New Yorkbus bus
    3. Take the bus from Port Authority Bus Terminal to St Louis Bus Stationbus bus
    32h 9m
    $233–394

  4. Drive  1,249.4 mi

    1. Drive from Portland to St. Louiscar car 1,249.4 mi
    22h 6m
    $228–330

  5. Bus

    1. Take the bus from Portland, ME to Boston, MA - South Stationbus bus
    2. Take the bus from Boston to Newark Penn Stationbus bus
    3. Take the bus from Newark Penn Station to St Louis Bus Stationbus bus
    32h 22m
    $218–379

Maine to St. Louis by bus and train

Calendar7Weekly Services
Duration31h 40mAverage Duration
Ticket$723Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Maine to St. Louis.ExpandLaunch map view
  • Distance: 1,107.1 mi
  • Duration: 5h 28m

What companies run services between Maine, USA and St. Louis, MO, USA?

Southwest Airlines, Delta, and American Airlines fly from Portland (PWM) to Lambert–St. Louis International Airport (STL) every 4 hours. Alternatively, you can take a bus from Portland Public Library to St Louis Bus Station via Portland, ME, Boston, MA - South Station, Boston, New York, and Port Authority Bus Terminal in around 32h 9m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

Booking & Getting There