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How to get fromMaine to St. Louisby plane, bus, train, bus (Amtrak, Greyhound), car, or bus (Amtrak, Greyhound, Flixbus)

Find Transport to St. Louis

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There are 5 ways to get from Maine to St. Louis by plane, bus, train, bus (Amtrak, Greyhound), car, or bus (Amtrak, Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Portland (PWM) to Lambert–St. Louis International Airport (STL)plane plane PWM - STL
    5h 23m
    $176–787

  2. Bus, train

    1. Take the bus from Portland, ME to Boston, MA - South Stationbus bus
    2. Take the train from Boston to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Louistrain train
    31h 41m
    $403–879

  3. Bus via New York

    1. Take the bus from Portland, ME to Boston, MA - South Stationbus bus
    2. Take the bus from Boston to New Yorkbus bus
    3. Take the bus from Port Authority Bus Terminal to St Louis Bus Stationbus bus
    32h 10m
    $213–449

  4. Drive 1,249.4 mi

    1. Drive from Portland to St. Louiscar car 1,249.4 mi
    22h 7m
    $228–330

  5. Bus

    1. Take the bus from Portland, ME to Boston, MA - South Stationbus bus
    2. Take the bus from Boston to Newark Penn Stationbus bus
    3. Take the bus from Newark Penn Station to St Louis Bus Stationbus bus
    32h 23m
    $198–404

Maine to St. Louis by bus and train

Calendar7Weekly Services
Duration31h 41mAverage Duration
Ticket$403Cheapest Price
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Questions & Answers

Map of how to get from Maine to St. Louis.ExpandLaunch map view
  • Distance: 1,107.1 mi
  • Duration: 5h 23m

What companies run services between Maine, USA and St. Louis, MO, USA?

Southwest Airlines, Delta, and United Airlines fly from Portland (PWM) to Lambert–St. Louis International Airport (STL) every 3 hours. Alternatively, you can take a bus from Portland Public Library to St Louis Bus Station via Portland, ME, Boston, MA - South Station, Boston, New York, and Port Authority Bus Terminal in around 32h 10m.

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