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How to get fromMaine to St. Louisby plane, bus, train, bus (Amtrak, Greyhound, Flixbus), car, or bus (Flixbus, Greyhound)

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There are 5 ways to get from Maine to St. Louis by plane, bus, train, bus (Amtrak, Greyhound, Flixbus), car, or bus (Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Portland (PWM) to Lambert–St. Louis International Airport (STL)plane plane PWM - STL
    5h 23m
    $188–847

  2. Bus, train

    1. Take the bus from Portland, ME to Boston, MA - South Stationbus bus
    2. Take the train from Boston to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Louistrain train
    31h 40m
    $443–939

  3. Bus via Boston

    1. Take the bus from Portland, ME to Boston, MA - South Stationbus bus
    2. Take the bus from Boston to Newark Penn Stationbus bus
    3. Take the bus from Newark Penn Station to St Louis Bus Stationbus bus
    32h 22m
    $213–414

  4. Drive 1,249.4 mi

    1. Drive from Portland to St. Louiscar car 1,249.4 mi
    22h 7m
    $228–330

  5. Bus

    1. Take the bus from City of Portland to New York Midtownbus bus FlixBus N2615
    2. Take the bus from Port Authority Bus Terminal to St Louis Bus Stationbus bus Greyhound US0421
    32h 35m
    $212–399

Maine to St. Louis by bus and train

Calendar7Weekly Services
Duration31h 40mAverage Duration
Ticket$443Cheapest Price
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Questions & Answers

Map of how to get from Maine to St. Louis.ExpandLaunch map view
  • Distance: 1,107.1 mi
  • Duration: 5h 23m

What companies run services between Maine, USA and St. Louis, MO, USA?

Southwest Airlines, Delta, and United Airlines fly from Portland (PWM) to Lambert–St. Louis International Airport (STL) every 4 hours. Alternatively, you can take a bus from Portland Public Library to St Louis Bus Station via Portland, ME, Boston, MA - South Station, Boston, and Newark Penn Station in around 32h 22m.

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