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How to get fromMaine to St. Louisby plane, bus (Amtrak, Greyhound, Flixbus), bus, train, or car

Find Transport to St. Louis

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There are 4 ways to get from Maine to St. Louis by plane, bus (Amtrak, Greyhound, Flixbus), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Portland (PWM) to Lambert–St. Louis International Airport (STL)plane plane PWM - STL
    5h 38m
    $171–801

  2. Bus

    1. Take the bus from Portland, ME to Boston, MA - South Stationbus bus
    2. Take the bus from Boston to Newark Penn Stationbus bus
    3. Take the bus from Newark Penn Station to St Louis Bus Stationbus bus
    31h 25m
    $243–394

  3. Bus, train

    1. Take the bus from Portland, ME to Boston, MA - South Stationbus bus
    2. Take the train from Boston to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Louistrain train
    31h 40m
    $723–1,189

  4. Drive  1,249.4 mi

    1. Drive from Portland to St. Louiscar car 1,249.4 mi
    22h 6m
    $214–309

Maine to St. Louis by bus

Calendar14Weekly Buses
Duration31h 25mAverage Duration
Ticket$243Cheapest Price
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Comparing Your Travel Options

Map of how to get from Maine to St. Louis.ExpandLaunch map view
  • Distance: 1,107.1 mi
  • Duration: 5h 38m

What companies run services between Maine, USA and St. Louis, MO, USA?

Southwest Airlines, Delta, and American Airlines fly from Portland (PWM) to Lambert–St. Louis International Airport (STL) 4 times a day. Alternatively, you can take a bus from Portland Public Library to St Louis Bus Station via Portland, ME, Boston, MA - South Station, Boston, and Newark Penn Station in around 31h 25m.

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Want to know more about travelling around United States

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Need to know: Greyhound

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