There are 8 ways to get from Mainz, Hauptbahnhof to Zurich by plane, train, bus, night train, or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly Frankfurt to Zurich Airport
best- Fly from Frankfurt (FRA) to Zurich Airport (ZRH)plane FRA - ZRH
2h 49mCHF 96–218Night train
cheapest- Take the nighttrain from Mainz Hbf to Zuerich Hbnighttrain Nj
6h 22mCHF 29–95Train via Basel
- Take the train from Mainz, Hauptbahnhof to Mannheim, Hauptbahnhoftrain 55 / ...
- Take the train from Mannheim, Hauptbahnhof to Basel SBBtrain 12 / ...
- Take the train from Basel SBB to Zürich HBtrain Tgv / ...
4h 47mCHF 68–140Bus
- Take the bus from Mainz central train station to Zurich Bus Stationbus FlixBus 476
8hCHF 35–60Fly Frankfurt to Basel, train
- Fly from Frankfurt (FRA) to Basel (BSL)plane FRA - BSL
- Take the train from Basel SBB to Zürich HBtrain
4h 8mCHF 150–388Train to Stuttgart Airport, fly to Zurich Airport
- Take the train from Mainz, Hauptbahnhof to Hauptbahnhoftrain
- Fly from Stuttgart Airport (STR) to Zurich Airport (ZRH)plane STR - ZRH
4h 35mCHF 142–350Train
- Take the train from Mainz, Hauptbahnhof to Ludwigshafen, Mittetrain S5 / ...
- Take the train from Ludwigshafen, Mitte to Karlsruhe Hauptbahnhoftrain S3 / ...
- Take the train from Karlsruhe Hbf to Zuerich Hbtrain Ec
7h 43mCHF 81–104Drive 373.3 km
- Drive from Mainz, Hauptbahnhof to Zurichcar 373.3 km
4h 4mCHF 73–105
Mainz, Hauptbahnhof to Zurich by train
Comparing Your Travel Options
The cheapest way to get from Mainz, Hauptbahnhof to Zurich is to bus which costs SFr 35 - SFr 60 and takes 8h.
The fastest way to get from Mainz, Hauptbahnhof to Zurich is to fly which takes 2h 49m and costs SFr 95 - SFr 220.
Yes, there is a direct bus departing from Mainz central train station station and arriving at Zurich Bus Station station. Services depart once daily, and operate every day. The journey takes approximately 8h.
Yes, there is an overnight train departing from Mainz Hbf and arriving at Zuerich Hb. This train operates every day. The journey takes approximately 6h 22m.
The distance between Mainz, Hauptbahnhof and Zurich is 330 km. The road distance is 373.3 km.
The best way to get from Mainz, Hauptbahnhof to Zurich without a car is to train via Basel which takes 4h 47m and costs SFr 65 - SFr 140.
It takes approximately 2h 49m to get from Mainz, Hauptbahnhof to Zurich, including transfers.
Mainz, Hauptbahnhof to Zurich bus services, operated by FlixBus, depart from Mainz central train station.
Mainz, Hauptbahnhof to Zurich train services, operated by Deutsche Bahn Intercity (DB IC), depart from Mainz, Hauptbahnhof station.
The best way to get from Mainz, Hauptbahnhof to Zurich is to fly which takes 2h 49m and costs SFr 95 - SFr 220. Alternatively, you can train via Basel, which costs SFr 65 - SFr 140 and takes 4h 47m, you could also bus, which costs SFr 35 - SFr 60 and takes 8h.
What companies run services between Mainz, Hauptbahnhof, Germany and Zurich, Switzerland?
Lufthansa, Condor Flugdienst, and Air Dolomiti fly from Frankfurt (FRA) to Zurich Airport (ZRH) every 2 hours. Alternatively, you can take a train from Mainz, Hauptbahnhof to Zürich HB via Mannheim, Hauptbahnhof and Basel SBB in around 4h 47m.
- Website
- lufthansa.com
Flights from Frankfurt to Zurich Airport
- Ave. Duration
- 55 min
- When
- Every day
- Estimated price
- CHF 70–400
Flights from Frankfurt to Basel
- Ave. Duration
- 55 min
- When
- Every day
- Estimated price
- CHF 75–460
Flights from Frankfurt to Basel via Munich
- Ave. Duration
- 2h 50m
- When
- Tuesday, Thursday, and Saturday
- Estimated price
- CHF 75–420
- Website
- swiss.com
Flights from Frankfurt to Zurich Airport
- Ave. Duration
- 55 min
- When
- Every day
- Estimated price
- CHF 70–400
Flights from Frankfurt to Basel
- Ave. Duration
- 55 min
- When
- Every day
- Estimated price
- CHF 75–420
Flights from Stuttgart Airport to Zurich Airport
- Ave. Duration
- 45 min
- When
- Every day
- Estimated price
- CHF 60–330
- Website
- condor.com
Flights from Frankfurt to Zurich Airport
- Ave. Duration
- 50 min
- When
- Every day
- Estimated price
- CHF 90–210
- Website
- airdolomiti.it
Flights from Frankfurt to Zurich Airport
- Ave. Duration
- 55 min
- When
- Every day
- Estimated price
- CHF 130–400
Flights from Frankfurt to Basel
- Ave. Duration
- 55 min
- When
- Monday, Wednesday, Friday, Saturday, and Sunday
- Estimated price
- CHF 150–460
- Phone
- +49 30 2970
- Website
- Deutsche Bahn Intercity (DB IC)
Train from Mainz, Hauptbahnhof to Mannheim, Hauptbahnhof
- Ave. Duration
- 39 min
- Frequency
- Every 3 hours
- Estimated price
- CHF 10–20
- Website
- Deutsche Bahn Intercity (DB IC)
Train from Mannheim, Hauptbahnhof to Basel SBB
- Ave. Duration
- 2h 12m
- Frequency
- Hourly
- Estimated price
- CHF 35–75
- Website
- Deutsche Bahn Intercity (DB IC)
Train from Mainz, Hauptbahnhof to Hauptbahnhof
- Ave. Duration
- 1h 41m
- Frequency
- Every 4 hours
- Estimated price
- CHF 26–55
- Website
- Deutsche Bahn Intercity (DB IC)
- Phone
- +49 30 2970
- Website
- Deutsche Bahn Regio (DB Regional)
Train from Mainz, Hauptbahnhof to Mannheim, Hauptbahnhof
- Ave. Duration
- 1h 20m
- Frequency
- Hourly
- Estimated price
- CHF 7–10
- Website
- Deutsche Bahn Regio (DB Regional)
Train from Mainz, Hauptbahnhof to Ludwigshafen, Mitte
- Ave. Duration
- 1h 16m
- Frequency
- Hourly
- Estimated price
- CHF 7–10
- Website
- Deutsche Bahn Regio (DB Regional)
Train from Ludwigshafen, Mitte to Karlsruhe Hauptbahnhof
- Ave. Duration
- 1h 13m
- Frequency
- Every 30 minutes
- Estimated price
- CHF 7–11
- Website
- Deutsche Bahn Regio (DB Regional)
- Phone
- +49 621 830 1200
- Website
- Süwex
Train from Mainz, Hauptbahnhof to Mannheim, Hauptbahnhof
- Ave. Duration
- 50 min
- Frequency
- Every 3 hours
- Estimated price
- CHF 13–19
- Schedules at
- Süwex
Train from Mainz, Hauptbahnhof to Ludwigshafen, Mitte
- Ave. Duration
- 46 min
- Frequency
- Every 4 hours
- Estimated price
- CHF 13–19
- Schedules at
- Süwex
Train from Ludwigshafen, Mitte to Karlsruhe Hauptbahnhof
- Ave. Duration
- 1h 3m
- Frequency
- 5 times a week
- Estimated price
- CHF 13–19
- Schedules at
- Süwex
Train from Basel SBB to Zürich HB
- Ave. Duration
- 1h 13m
- Frequency
- Every 20 minutes
- Estimated price
- CHF 26–45
- Website
- Swiss Federal Railways (SBB CFF FFS)
Train from Basel SBB to Zürich HB
- Ave. Duration
- 1h 13m
- Frequency
- Every 20 minutes
- Estimated price
- CHF 26–45
- Website
- Swiss Federal Railways (SBB CFF FFS)
- Phone
- +31 30 751 5155
- Website
- Nederlandse Spoorwegen (NS)
Night train from Mainz Hbf to Zuerich Hb
- Ave. Duration
- 6h 22m
- Frequency
- Twice daily
- Estimated price
- CHF 45–85
- Website
- Nederlandse Spoorwegen (NS)
- Phone
- +43 (0) 51717
- Website
- Nightjet
Night train from Mainz Hbf to Zuerich Hb
- Ave. Duration
- 6h 22m
- Frequency
- 6 times a week
- Estimated price
- CHF 29–93
- Website
- Nightjet
- Sleeper Carriage
- CHF 89–93
- Couchette Carriage
- CHF 55–70
- Seating Carriage
- CHF 29–35
- Phone
- +43 (0) 5 1717
- Website
- ÖBB EuroCity
Train from Karlsruhe Hbf to Zuerich Hb
- Ave. Duration
- 3h 56m
- Frequency
- Twice a week
- Estimated price
- CHF 67
- Website
- ÖBB EuroCity
- Website
- ÖBB EuroCity
Rome2Rio's guide to FlixBus
Contact Details
- Phone
- +49 30 300 137 300
- [email protected]
- Website
- Flixbus
Bus from Mainz central train station to Zurich Bus Station
- Ave. Duration
- 8h
- Frequency
- Once daily
- Estimated price
- CHF 35–60
- Website
- Flixbus
Want to know more about travelling around Switzerland
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Heading to Europe? Read this before you buy a Eurail Pass
Read the travel guide
Want to know more about Flixbus?
Read the travel guide
5 delightfully under-the-radar French towns you need to visit
Read the travel guide
Booking & Getting There
Mainz, Hauptbahnhof to Zurich bus services, operated by FlixBus, arrive at Zurich Bus Station.
Mainz, Hauptbahnhof to Zurich train services, operated by Deutsche Bahn Intercity (DB IC), arrive at Mannheim, Hauptbahnhof station.
Yes, the driving distance between Mainz, Hauptbahnhof to Zurich is 373 km. It takes approximately 4h 4m to drive from Mainz, Hauptbahnhof to Zurich.
Book your Mainz, Hauptbahnhof to Zurich train tickets online with Omio.
Book your Mainz, Hauptbahnhof to Zurich bus tickets online with Omio and FlixBus.
There are 1226+ hotels available in Zurich.









































