Rome2Rio

How to get fromMainz to Sienaby plane, train, train (Trenitalia), bus, night train, or car

Find Transport to Siena

See all options

There are 9 ways to get from Mainz to Siena by plane, train, train (Trenitalia), bus, night train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Florence Peretola Airport, train

    best
    1. Fly from Frankfurt (FRA) to Florence Peretola Airport (FLR)plane plane FRA - FLR
    2. Take the train from Firenze S.M.N. to Sienatrain train
    6h 21m
    €137–318

  2. Bus via Frankfurt am Main

    cheapest
    1. Take the bus from Frankfurt central train station to Florence Villa Constanza Bus Stationbus bus N77 / ...
    2. Take the bus from Florence Villa Constanza Bus Station to Sienabus bus 1518 / ...
    20h 8m
    €96–167

  3. Train

    1. Take the train from Frankfurt to Chiassotrain train Ec
    2. Take the train from Chiasso to Milano Centraletrain train S11
    3. Take the train from Milano Centrale to Firenze S.M.N.train train Fr
    4. Take the train from Firenze S.M.N. to Sienatrain train Re
    14h 3m
    €252–422

  4. Bus

    1. Take the bus from Wiesbaden Gartenfeldstraße P+R to Florence Villa Constanza Bus Stationbus bus
    2. Take the bus from Florence Villa Constanza Bus Station to Sienabus bus 1518 / ...
    18h 12m
    €139–203

  5. Train, night train

    1. Take the train from Mainz, Römisches Theater to Mannheim, Hauptbahnhoftrain train S5 / ...
    2. Take the train from Mannheim, Hauptbahnhof to Hauptbahnhoftrain train 47 / ...
    3. Take the nighttrain from Stuttgart Hbf to Verona Porta Nuovanighttrain night train Nj
    4. Take the train from Verona Porta Nuova to Firenze S.M.N.train train Fr
    5. Take the train from Firenze S.M.N. to Sienatrain train Re
    20h 7m
    €106–287

  6. Fly to Pisa International Airport, train

    1. Fly from Frankfurt (FRA) to Pisa International Airport (PSA)plane plane FRA - PSA
    2. Take the train from Pisa Centrale to Empolitrain train
    3. Take the train from Empoli to Sienatrain train
    6h 13m
    €121–306

  7. Fly to Bologna Guglielmo Marconi Airport, train

    1. Fly from Frankfurt (FRA) to Bologna Guglielmo Marconi Airport (BLQ)plane plane FRA - BLQ
    2. Take the train from Bologna Centrale to Firenze S.M.N.train train
    3. Take the train from Firenze S.M.N. to Sienatrain train
    6h 46m
    €124–308

  8. Fly to Venice Marco Polo Airport, train

    1. Fly from Frankfurt (FRA) to Venice Marco Polo Airport (VCE)plane plane FRA - VCE
    2. Take the train from Venezia Mestre to Firenze S.M.N.train train
    3. Take the train from Firenze S.M.N. to Sienatrain train
    8h 29m
    €124–298

  9. Drive  1,023.6 km

    1. Drive from Mainz to Sienacar car 1,023.6 km
    9h 48m
    €166–239

Mainz to Siena by train

Calendar6Weekly Trains
Duration14h 3mAverage Duration
Ticket€252Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Mainz to Siena.ExpandLaunch map view
  • Distance: 847.3 km
  • Duration: 6h 21m

What companies run services between Mainz, Germany and Siena, Italy?

You can take a train from Mainz, Römisches Theater to Siena via Frankfurt, Chiasso, Milano Centrale, and Firenze S.M.N. in around 14h 3m. Alternatively, you can take a bus from Wiesbaden-Mainz-Kastel Bahnhof to Siena via Wiesbaden Hauptbahnhof, Wiesbaden Gartenfeldstraße P+R, and Florence Villa Constanza Bus Station in around 18h 12m.

Airlines
Train operators
Bus operators

Want to know more about travelling around Italy

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Italy Travel Guides

Read the travel guideItaly Travel Guides

Booking & Getting There