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How to get fromMainz to Sienaby plane, train, train (Trenitalia), bus, night train, or car

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There are 7 ways to get from Mainz to Siena by plane, train, train (Trenitalia), bus, night train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Florence Peretola Airport, train

    best
    1. Fly from Frankfurt (FRA) to Florence Peretola Airport (FLR)plane plane FRA - FLR
    2. Take the train from Firenze S.M.N. to Sienatrain train
    6h 41m
    €138–338

  2. Bus via Frankfurt am Main

    cheapest
    1. Take the bus from Frankfurt central train station to Florence Villa Constanza Bus Stationbus bus N77 / ...
    2. Take the bus from Florence Villa Constanza Bus Station to Sienabus bus 1518 / ...
    20h 8m
    €102–178

  3. Train

    1. Take the train from Frankfurt to Chiassotrain train Ec
    2. Take the train from Chiasso to Milano Centraletrain train S11
    3. Take the train from Milano Centrale to Firenze S.M.N.train train Fr
    4. Take the train from Firenze S.M.N. to Sienatrain train Re
    14h 49m
    €297–510

  4. Bus

    1. Take the bus from Wiesbaden Gartenfeldstraße P+R to Florence Villa Constanza Bus Stationbus bus
    2. Take the bus from Florence Villa Constanza Bus Station to Sienabus bus 1518 / ...
    18h 12m
    €139–203

  5. Train, night train, bus

    1. Take the train from Mainz, Römisches Theater to Mannheim, Hauptbahnhoftrain train S5 / ...
    2. Take the train from Mannheim, Hauptbahnhof to Hauptbahnhoftrain train 47 / ...
    3. Take the nighttrain from Stuttgart Hbf to Venezia Mestrenighttrain night train Nj
    4. Take the train from Venezia Mestre to Firenze S.M.N.train train Fr
    5. Take the bus from Firenze Autostazione to Siena-Via Tozzibus bus 131
    19h 26m
    €103–293

  6. Fly to Bologna Guglielmo Marconi Airport, train

    1. Fly from Frankfurt (FRA) to Bologna Guglielmo Marconi Airport (BLQ)plane plane FRA - BLQ
    2. Take the train from Bologna Centrale to Firenze S.M.N.train train
    3. Take the train from Firenze S.M.N. to Sienatrain train
    7h 14m
    €120–318

  7. Drive  1,023.6 km

    1. Drive from Mainz to Sienacar car 1,023.6 km
    9h 48m
    €166–240

Mainz to Siena by train

Calendar6Weekly Trains
Duration14h 49mAverage Duration
Ticket€297Cheapest Price
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Map of how to get from Mainz to Siena.ExpandLaunch map view
  • Distance: 847.3 km
  • Duration: 6h 41m

What companies run services between Mainz, Germany and Siena, Italy?

You can take a train from Mainz, Römisches Theater to Siena via Frankfurt, Chiasso, Milano Centrale, and Firenze S.M.N. in around 14h 49m. Alternatively, you can take a bus from Wiesbaden-Mainz-Kastel Bahnhof to Siena via Wiesbaden Hauptbahnhof, Wiesbaden Gartenfeldstraße P+R, and Florence Villa Constanza Bus Station in around 18h 12m.

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