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How to get fromMainz to Sienaby plane, train, train (Trenitalia), bus, night train, or car

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There are 11 ways to get from Mainz to Siena by plane, train, train (Trenitalia), bus, night train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Florence Peretola Airport, train

    best
    1. Fly from Frankfurt (FRA) to Florence Peretola Airport (FLR)plane plane FRA - FLR
    2. Take the train from Firenze S.M.N. to Sienatrain train
    6h 31m
    €138–303

  2. Fly to Milan Linate Airport, train

    cheapest
    1. Fly from Frankfurt (FRA) to Milan Linate Airport (LIN)plane plane FRA - LIN
    2. Take the train from Milano Rogoredo to Firenze S.M.N.train train
    3. Take the train from Firenze S.M.N. to Sienatrain train
    8h 7m
    €88–266

  3. Train via Basel

    1. Take the train from Mainz, Hauptbahnhof to Mannheim, Hauptbahnhoftrain train 55 / ...
    2. Take the train from Mannheim, Hauptbahnhof to Basel SBBtrain train 12 / ...
    3. Take the train from Basel SBB to Luganotrain train Ec
    4. Take the train from Lugano to Milano Centraletrain train
    5. Take the train from Milano Centrale to Firenze S.M.N.train train Fr
    6. Take the train from Firenze S.M.N. to Sienatrain train Re
    13h 23m
    €125–716

  4. Bus

    1. Take the bus from Wiesbaden Gartenfeldstraße P+R to Florence Villa Constanza Bus Stationbus bus
    2. Take the bus from Florence Villa Constanza Bus Station to Sienabus bus N528 / ...
    18h 22m

  5. Train, night train

    1. Take the train from Mainz, Römisches Theater to Mannheim, Hauptbahnhoftrain train S5 / ...
    2. Take the train from Mannheim, Hauptbahnhof to Hauptbahnhoftrain train 11 / ...
    3. Take the night train from Stuttgart Hbf to Verona Porta Nuovanighttrain night train Nj
    4. Take the train from Verona Porta Nuova to Firenze S.M.N.train train Fr
    5. Take the train from Firenze S.M.N. to Sienatrain train Re
    20h 9m
    €112–310

  6. Fly to Pisa International Airport, train

    1. Fly from Frankfurt (FRA) to Pisa International Airport (PSA)plane plane FRA - PSA
    2. Take the train from Pisa Centrale to Empolitrain train
    3. Take the train from Empoli to Sienatrain train
    6h 14m
    €122–262

  7. Fly to Bologna Guglielmo Marconi Airport, train

    1. Fly from Frankfurt (FRA) to Bologna Guglielmo Marconi Airport (BLQ)plane plane FRA - BLQ
    2. Take the train from Bologna Centrale to Firenze S.M.N.train train
    3. Take the train from Firenze S.M.N. to Sienatrain train
    6h 46m
    €120–278

  8. Fly to Venice Marco Polo Airport, train

    1. Fly from Frankfurt (FRA) to Venice Marco Polo Airport (VCE)plane plane FRA - VCE
    2. Take the train from Venezia Mestre to Firenze S.M.N.train train
    3. Take the train from Firenze S.M.N. to Sienatrain train
    8h 29m
    €112–303

  9. Train

    1. Take the train from Frankfurt to Chiassotrain train Ec
    2. Take the train from Chiasso to Milano Centraletrain train S11
    3. Take the train from Milano Centrale to Firenze S.M.N.train train Fr
    4. Take the train from Firenze S.M.N. to Sienatrain train Re
    14h 2m
    €287–883

  10. Bus via Frankfurt am Main

    1. Take the bus from Frankfurt central train station to Florence Villa Constanza Bus Stationbus bus N77 / ...
    2. Take the bus from Florence Villa Constanza Bus Station to Sienabus bus N528 / ...
    20h 7m
    €98–175

  11. Drive 1,023.6 km

    1. Drive from Mainz to Sienacar car 1,023.6 km
    9h 48m
    €161–233

Mainz to Siena by train

Calendar76Weekly Trains
Duration13h 23mAverage Duration
Ticket€125Cheapest Price
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Questions & Answers

Map of how to get from Mainz to Siena.ExpandLaunch map view
  • Distance: 847.3 km
  • Duration: 6h 31m

What companies run services between Mainz, Germany and Siena, Italy?

You can take a train from Mainz, Hauptbahnhof to Siena via Mannheim, Hauptbahnhof, Basel SBB, Lugano, Milano Centrale, and Firenze S.M.N. in around 13h 23m. Alternatively, you can take a bus from Mainz, Brückenplatz to Siena via Wiesbaden Hauptbahnhof, Wiesbaden Gartenfeldstraße P+R, and Florence Villa Constanza Bus Station in around 18h 22m.

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