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How to get fromManchester to Chicagoby plane, bus (Greyhound), bus, train, car, or bus (Greyhound, Flixbus)

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There are 8 ways to get from Manchester to Chicago by plane, bus (Greyhound), bus, train, car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Manchester Airport to Chicago Midway International Airport

    best
    1. Fly from Manchester Airport (MHT) to Chicago Midway International Airport (MDW)plane plane MHT - MDW
    4h 21m
    $123–656

  2. Bus to Boston Logan Airport, fly to Chicago Midway International Airport

    cheapest
    1. Take the bus from Manchester(Veterans Memorial Park) to Bostonbus bus
    2. Fly from Boston Logan Airport (BOS) to Chicago Midway International Airport (MDW)plane plane BOS - MDW
    6h 30m
    $97–461

  3. Bus via Brook Park (Greyhound)

    1. Take the bus from Manchester(Veterans Memorial Park) to Bostonbus bus
    2. Take the bus from Boston to Cleveland Bus Stationbus bus
    3. Take the bus from Cleveland Bus Station to Chicago Bus Stationbus bus
    24h 40m
    $159–269

  4. Bus, train

    1. Take the bus from Manchester(Veterans Memorial Park) to Bostonbus bus Greyhound US0260
    2. Take the train from Boston to Chicago Union Stationtrain train Lake Shore Limited
    24h 47m
    $269–614

  5. Drive  953.7 mi

    1. Drive from Manchester to Chicagocar car 953.7 mi
    17h 35m
    $174–252

  6. Fly Manchester Airport to Chicago O'Hare International Airport

    1. Fly from Manchester Airport (MHT) to Chicago O'Hare International Airport (ORD)plane plane MHT - ORD
    4h 53m
    $103–556

  7. Bus to Boston Logan Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from Manchester(Veterans Memorial Park) to Bostonbus bus
    2. Fly from Boston Logan Airport (BOS) to Chicago O'Hare International Airport (ORD)plane plane BOS - ORD
    6h 46m
    $612–921

  8. Bus

    1. Take the bus from Manchester(Veterans Memorial Park) to Bostonbus bus
    2. Take the bus from Boston to New York Midtownbus bus
    3. Take the bus from New York Midtown to Chicago Bus Stationbus bus
    28h 10m
    $179–284

Manchester to Chicago by bus (Greyhound)

Calendar7Weekly Buses
Duration24h 40mAverage Duration
Ticket$159Cheapest Price
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Comparing Your Travel Options

Map of how to get from Manchester to Chicago.ExpandLaunch map view
  • Distance: 851.1 mi
  • Duration: 4h 21m

What companies run services between Manchester, NH, USA and Chicago, IL, USA?

Southwest Airlines flies from Manchester Airport (MHT) to Chicago Midway International Airport (MDW) 3 times a day. Alternatively, you can take a bus from Manchester(Veterans Memorial Park) to Chicago Bus Station via Boston and Cleveland Bus Station in around 24h 40m.

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