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How to get fromManchester to Des Moinesby plane, bus (Greyhound, Flixbus), bus, train, car, or bus (Greyhound)

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There are 7 ways to get from Manchester to Des Moines by plane, bus (Greyhound, Flixbus), bus, train, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Manchester Airport

    best
    1. Fly from Manchester Airport (MHT) to Des Moines (DSM)plane plane MHT - DSM
    6h 16m
    $208–923

  2. Bus to Boston Logan Airport, fly

    cheapest
    1. Take the bus from Manchester(Veterans Memorial Park) to Bostonbus bus
    2. Fly from Boston Logan Airport (BOS) to Des Moines (DSM)plane plane BOS - DSM
    6h 4m
    $196–839

  3. Bus

    1. Take the bus from Manchester(Veterans Memorial Park) to Bostonbus bus
    2. Take the bus from Boston to New York Midtownbus bus
    3. Take the bus from New York Midtown to Chicago Bus Stationbus bus
    4. Take the bus from Chicago to Des Moinesbus bus
    31h 53m

  4. Bus, train

    1. Take the bus from Manchester(Veterans Memorial Park) to Bostonbus bus
    2. Take the train from Boston to Chicago Union Stationtrain train
    3. Take the bus from Chicago to Des Moinesbus bus
    32h 41m

  5. Drive 1,269.3 mi

    1. Drive from Manchester to Des Moinescar car 1,269.3 mi
    22h 49m
    $232–335

  6. Bus, train via Galesburg

    1. Take the bus from Manchester(Veterans Memorial Park) to Bostonbus bus
    2. Take the train from Boston to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Galesburg Amtrak Stationtrain train
    4. Take the bus from Galesburg to Des Moinesbus bus
    33h 53m
    $418–885

  7. Bus via Indianapolis

    1. Take the bus from Manchester(Veterans Memorial Park) to Bostonbus bus
    2. Take the bus from Boston to Port Authority Bus Terminalbus bus
    3. Take the bus from Port Authority Bus Terminal to Indianapolis Union Stationbus bus
    4. Take the bus from Indianapolis Union Station to Des Moinesbus bus
    35h 19m
    $228–460

Manchester Airport (MHT) to Des Moines (DSM) flights

Calendar65Weekly Planes
Duration7h 21mAverage Duration
Ticket$198Cheapest Price
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Questions & Answers

Map of how to get from Manchester to Des Moines.ExpandLaunch map view
  • Distance: 1,148.9 mi
  • Duration: 6h 16m

What companies run services between Manchester, NH, USA and Des Moines, IA, USA?

Southwest Airlines and American Airlines fly from Manchester Airport (MHT) to Des Moines (DSM) every 3 hours. Alternatively, you can take a bus from Manchester(Veterans Memorial Park) to Des Moines via Boston, New York Midtown, and Chicago in around 31h 53m.

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