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How to get fromManchester to Florenceby plane, bus (Greyhound, Flixbus), bus, train, car, or bus (Greyhound)

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There are 5 ways to get from Manchester to Florence by plane, bus (Greyhound, Flixbus), bus, train, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Manchester Airport (MHT) to Florence Regional Airport (FLO)plane plane MHT - FLO
    7h 8m
    $106–505

  2. Bus

    1. Take the bus from Manchester(Veterans Memorial Park) to Bostonbus bus
    2. Take the bus from Boston to NYC Downtownbus bus
    3. Take the bus from New York, NY to Florence, SCbus bus Nyc
    20h 19m
    $124–206

  3. Bus, train

    1. Take the bus from Manchester(Veterans Memorial Park) to Bostonbus bus
    2. Take the train from Boston to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the train from Ny Moynihan Train Hall At Penn Station to Florence Stationtrain train
    21h 50m
    $259–1,186

  4. Drive 857.1 mi

    1. Drive from Manchester to Florencecar car 857.1 mi
    15h 38m
    $157–226

  5. Bus via Raleigh (Greyhound)

    1. Take the bus from Manchester(Veterans Memorial Park) to Bostonbus bus
    2. Take the bus from Boston to Port Authority Bus Terminalbus bus
    3. Take the bus from Port Authority Bus Terminal to Raleigh Bus Stationbus bus
    4. Take the bus from Raleigh Bus Station to Florence Bus Stationbus bus
    21h 19m
    $142–286

Manchester to Florence by bus and train

Calendar14Weekly Services
Duration21h 50mAverage Duration
Ticket$259Cheapest Price
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Questions & Answers

Map of how to get from Manchester to Florence.ExpandLaunch map view
  • Distance: 758.4 mi
  • Duration: 7h 8m

What companies run services between Manchester, NH, USA and Florence, SC, USA?

American Airlines flies from Manchester Airport (MHT) to Florence Regional Airport (FLO) 4 times a day. Alternatively, you can take a bus from Manchester(Veterans Memorial Park) to Florence, SC via Boston, NYC Downtown, and New York, NY in around 20h 19m.

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