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How to get fromManchester to St. Louisby plane, bus (Greyhound), bus, train, or car

Find Transport to St. Louis

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There are 5 ways to get from Manchester to St. Louis by plane, bus (Greyhound), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Manchester Airport

    best
    1. Fly from Manchester Airport (MHT) to Lambert–St. Louis International Airport (STL)plane plane MHT - STL
    6h 43m
    $134–654

  2. Bus

    1. Take the bus from Manchester(Veterans Memorial Park) to Bostonbus bus
    2. Take the bus from Boston to New Yorkbus bus
    3. Take the bus from Port Authority Bus Terminal to St Louis Bus Stationbus bus
    30h 22m
    $230–370

  3. Bus, train

    1. Take the bus from Manchester(Veterans Memorial Park) to Bostonbus bus
    2. Take the train from Boston to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Louistrain train
    30h 33m
    $710–1,155

  4. Drive  1,159.9 mi

    1. Drive from Manchester to St. Louiscar car 1,159.9 mi
    21h 6m
    $212–306

  5. Bus to Boston Logan Airport, fly

    1. Take the bus from Manchester(Veterans Memorial Park) to Bostonbus bus
    2. Fly from Boston Logan Airport (BOS) to Lambert–St. Louis International Airport (STL)plane plane BOS - STL
    6h 57m
    $474–920

Manchester to St. Louis by bus

Calendar14Weekly Buses
Duration30h 22mAverage Duration
Ticket$230Cheapest Price
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Comparing Your Travel Options

Map of how to get from Manchester to St. Louis.ExpandLaunch map view
  • Distance: 1,047.6 mi
  • Duration: 6h 43m

What companies run services between Manchester, NH, USA and St. Louis, MO, USA?

Southwest Airlines and American Airlines fly from Manchester Airport (MHT) to Lambert–St. Louis International Airport (STL) every 4 hours. Alternatively, you can take a bus from Manchester(Veterans Memorial Park) to St Louis Bus Station via Boston, New York, and Port Authority Bus Terminal in around 30h 22m.

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