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How to get fromManchester to St. Louisby plane, bus, train, bus (Greyhound), car, or bus (Greyhound, Flixbus)

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There are 6 ways to get from Manchester to St. Louis by plane, bus, train, bus (Greyhound), car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Manchester Airport

    best
    1. Fly from Manchester Airport (MHT) to Lambert–St. Louis International Airport (STL)plane plane MHT - STL
    6h 23m
    $164–805

  2. Bus, train

    1. Take the bus from Manchester(Veterans Memorial Park) to Bostonbus bus
    2. Take the train from Boston to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Louistrain train
    30h 8m
    $428–906

  3. Bus via New York

    1. Take the bus from Manchester(Veterans Memorial Park) to Bostonbus bus
    2. Take the bus from Boston to New Yorkbus bus
    3. Take the bus from Port Authority Bus Terminal to St Louis Bus Stationbus bus
    30h 32m
    $213–456

  4. Drive 1,159.9 mi

    1. Drive from Manchester to St. Louiscar car 1,159.9 mi
    21h 6m
    $212–306

  5. Bus to Boston Logan Airport, fly

    1. Take the bus from Manchester(Veterans Memorial Park) to Bostonbus bus
    2. Fly from Boston Logan Airport (BOS) to Lambert–St. Louis International Airport (STL)plane plane BOS - STL
    6h 15m
    $372–872

  6. Bus

    1. Take the bus from Manchester(Veterans Memorial Park) to Bostonbus bus
    2. Take the bus from Boston to Newark Penn Stationbus bus
    3. Take the bus from Newark Penn Station to St Louis Bus Stationbus bus
    30h 36m
    $198–396

Manchester to St. Louis by bus and train

Calendar7Weekly Services
Duration30h 8mAverage Duration
Ticket$428Cheapest Price
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Questions & Answers

Map of how to get from Manchester to St. Louis.ExpandLaunch map view
  • Distance: 1,047.6 mi
  • Duration: 6h 23m

What companies run services between Manchester, NH, USA and St. Louis, MO, USA?

Southwest Airlines, American Airlines, and United Airlines fly from Manchester Airport (MHT) to Lambert–St. Louis International Airport (STL) every 2 hours. Alternatively, you can take a bus from Manchester(Veterans Memorial Park) to St Louis Bus Station via Boston, New York, and Port Authority Bus Terminal in around 30h 32m.

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