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How to get fromManchester to Chicagoby car, plane, bus, train, or bus (Greyhound)

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There are 8 ways to get from Manchester to Chicago by car, plane, bus, train, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive to Huntsville International Airport-Carl T Jones Field, fly to Chicago O'Hare International Airport

    best
    1. Drive from Manchester to Huntsville International Airport-Carl T Jones Field (HSV)car car
    2. Fly from Huntsville International Airport-Carl T Jones Field (HSV) to Chicago O'Hare International Airport (ORD)plane plane HSV - ORD
    4h 46m
    $77–377

  2. Bus to Nashville, fly to Chicago Midway International Airport

    cheapest
    1. Take the bus from Manchester to Nashville Bus Stationbus bus
    2. Fly from Nashville (BNA) to Chicago Midway International Airport (MDW)plane plane BNA - MDW
    5h 5m
    $74–386

  3. Bus, train

    1. Take the bus from Manchester to Nashville Bus Stationbus bus
    2. Take the bus from Nashville Bus Station to Carbondale Intermodal Stationbus bus
    3. Take the train from Carbondale to Chicago Union Stationtrain train
    12h 35m
    $140–284

  4. Bus

    1. Take the bus from Manchester to Chicago Bus Stationbus bus Greyhound US0100
    13h 50m
    $85–170

  5. Drive 494.3 mi

    1. Drive from Manchester to Chicagocar car 494.3 mi
    9h 35m
    $91–131

  6. Bus to Chattanooga Metropolitan Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from Monteagle to Groome Transportation Chattanoogabus bus
    2. Fly from Chattanooga Metropolitan Airport (CHA) to Chicago O'Hare International Airport (ORD)plane plane CHA - ORD
    5h 24m
    $194–590

  7. Bus to Nashville, fly to Chicago O'Hare International Airport

    1. Take the bus from Manchester to Nashville Bus Stationbus bus
    2. Fly from Nashville (BNA) to Chicago O'Hare International Airport (ORD)plane plane BNA - ORD
    5h 35m
    $114–326

  8. Drive to Mcghee Tyson Airport, fly to Chicago O'Hare International Airport

    1. Drive from Manchester to Mcghee Tyson Airport (TYS)car car
    2. Fly from Mcghee Tyson Airport (TYS) to Chicago O'Hare International Airport (ORD)plane plane TYS - ORD
    5h 49m
    $99–434

Manchester to Chicago by bus and train

Calendar12Weekly Services
Duration12h 35mAverage Duration
Ticket$140Cheapest Price
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Questions & Answers

Map of how to get from Manchester to Chicago.ExpandLaunch map view
  • Distance: 609.5 mi
  • Duration: 4h 46m

What companies run services between Manchester, TN, USA and Chicago, IL, USA?

Greyhound USA operates a bus from Manchester to Chicago Bus Station twice daily. Tickets cost $85–170 and the journey takes 13h 50m. Greyhound-us also services this route twice daily.

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