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How to get fromManchester to St. Louisby bus, plane, bus (Greyhound, Flixbus), car, or bus (Greyhound, Flixbus, Amtrak)

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There are 6 ways to get from Manchester to St. Louis by bus, plane, bus (Greyhound, Flixbus), car, or bus (Greyhound, Flixbus, Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Nashville, fly

    best
    1. Take the bus from Manchester to Nashville Bus Stationbus bus
    2. Fly from Nashville (BNA) to Lambert–St. Louis International Airport (STL)plane plane BNA - STL
    4h 47m
    $95–623

  2. Bus

    cheapest
    1. Take the bus from Manchester to Nashville Bus Stationbus bus Greyhound US0105 / ...
    2. Take the bus from Nashville Bus Station to St Louis Bus Stationbus bus Greyhound US0186 / ...
    8h 55m
    $55–113

  3. Drive 368.9 mi

    1. Drive from Manchester to St. Louiscar car 368.9 mi
    6h 5m
    $68–98

  4. Bus to Chattanooga Metropolitan Airport, fly

    1. Take the bus from Monteagle to Groome Transportation Chattanoogabus bus
    2. Fly from Chattanooga Metropolitan Airport (CHA) to Lambert–St. Louis International Airport (STL)plane plane CHA - STL
    6h 50m
    $275–1,038

  5. Bus to Hartsfield-Jackson Atlanta International Airport, fly

    1. Take the bus from Manchester to Atlanta Bus Stationbus bus
    2. Fly from Hartsfield-Jackson Atlanta International Airport (ATL) to Lambert–St. Louis International Airport (STL)plane plane ATL - STL
    7h 2m
    $134–660

  6. Bus via Carbondale

    1. Take the bus from Manchester to Nashville Bus Stationbus bus
    2. Take the bus from Nashville Bus Station to Carbondale Intermodal Stationbus bus
    3. Take the bus from Carbondale to St. Louisbus bus
    9h 10m
    $55–128

Manchester to St. Louis by bus

Calendar19Weekly Buses
Duration8h 55mAverage Duration
Ticket$55Cheapest Price
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Questions & Answers

Map of how to get from Manchester to St. Louis.ExpandLaunch map view
  • Distance: 357.5 mi
  • Duration: 4h 47m

What companies run services between Manchester, TN, USA and St. Louis, MO, USA?

You can take a bus from Manchester to St Louis Bus Station via Nashville Bus Station in around 8h 55m.

Airlines
Bus operators

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