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How to get fromManhattan to Knoxvilleby plane, car, train, bus, bus (Greyhound), or bus (Greyhound, Flixbus)

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There are 8 ways to get from Manhattan to Knoxville by plane, car, train, bus, bus (Greyhound), or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Mcghee Tyson Airport

    best
    1. Fly from Manhattan Regional Airport (MHK) to Mcghee Tyson Airport (TYS)plane plane MHK - TYS
    5h 2m
    $246–907

  2. Fly to Asheville Regional Airport, drive

    cheapest
    1. Fly from Manhattan Regional Airport (MHK) to Asheville Regional Airport (AVL)plane plane MHK - AVL
    2. Drive from Asheville-Airport-AVL to Knoxvillecar car
    10h 10m
    $148–532

  3. Drive, train, bus

    1. Drive from Manhattan to Topeka Stationcar car
    2. Take the train from Topeka Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Croton-Harmon Amtrak Stationtrain train
    4. Take the train from Croton-Harmon to 125th Street - Harlemtrain train
    5. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    46h 30m
    $608–1,175

  4. Bus

    1. Take the bus from Manhattan KS to St Louis Bus Stationbus bus
    2. Take the bus from St Louis Bus Station to Port Authority Bus Terminalbus bus
    3. Take the bus from New York to Knoxvillebus bus Nyc
    47h 32m
    $393–666

  5. Drive 835.7 mi

    1. Drive from Manhattan to Knoxvillecar car 835.7 mi
    14h 31m
    $153–221

  6. Fly to Chattanooga Metropolitan Airport, drive

    1. Fly from Manhattan Regional Airport (MHK) to Chattanooga Metropolitan Airport (CHA)plane plane MHK - CHA
    2. Drive from Chattanooga Metropolitan Airport (CHA) to Knoxvillecar car
    6h 37m
    $229–915

  7. Bus, train

    1. Take the bus from Manhattan KS to Kansas City Bus Stationbus bus
    2. Take the train from Kansas City to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    4. Take the bus from New York to Knoxvillebus bus Nyc
    47h 22m
    $636–1,236

  8. Bus via Auburn Gresham

    1. Take the bus from Manhattan KS to St Louis Bus Stationbus bus
    2. Take the bus from St Louis Bus Station to Chicagobus bus
    3. Take the bus from Chicago to New York City Chinatownbus bus
    4. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    2d 5h
    $354–573

Manhattan Regional Airport (MHK) to Mcghee Tyson Airport (TYS) flights

Calendar21Weekly Planes
Duration5h 21mAverage Duration
Ticket$166Cheapest Price
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Questions & Answers

Map of how to get from Manhattan to Knoxville.ExpandLaunch map view
  • Distance: 751.7 mi
  • Duration: 5h 2m

What companies run services between Manhattan, KS, USA and Knoxville, TN, USA?

American Airlines flies from Manhattan Regional Airport (MHK) to Mcghee Tyson Airport (TYS) 3 times a day. Alternatively, you can take a bus from Manhattan KS to Knoxville via St Louis Bus Station, Port Authority Bus Terminal, 34 St-Herald Sq, East Broadway, New York, and Knoxville in around 47h 32m.

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