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How to get fromManhattan to St. Louisby bus (Greyhound), bus, train, car, or plane

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There are 7 ways to get from Manhattan to St. Louis by bus (Greyhound), bus, train, car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus (Greyhound)

    best
    1. Take the bus from Manhattan KS to St Louis Bus Stationbus bus Greyhound US0180s
    8h 5m
    $60–120

  2. Bus, train

    1. Take the bus from Manhattan KS to Kansas City Bus Stationbus bus Greyhound US0180s
    2. Take the train from Kansas City to St. Louistrain train Missouri River Runner / ...
    10h 36m
    $113–234

  3. Drive 366.2 mi

    1. Drive from Manhattan to St. Louiscar car 366.2 mi
    6h 9m
    $67–97

  4. Fly Manhattan Regional Airport to Lambert–St. Louis International Airport

    1. Fly from Manhattan Regional Airport (MHK) to Lambert–St. Louis International Airport (STL)plane plane MHK - STL
    5h 48m
    $144–640

  5. Bus to Kansas City, fly to Lambert–St. Louis International Airport

    1. Take the bus from Manhattan KS to Kansas City Bus Stationbus bus
    2. Fly from Kansas City (MCI) to Lambert–St. Louis International Airport (STL)plane plane MCI - STL
    7h 40m
    $111–647

  6. Fly Manhattan Regional Airport to Abraham Lincoln Capital Airport, train

    1. Fly from Manhattan Regional Airport (MHK) to Abraham Lincoln Capital Airport (SPI)plane plane MHK - SPI
    2. Take the train from Springfield to St. Louistrain train
    9h 55m
    $144–498

  7. Bus to Salina Municipal Airport, fly to Lambert–St. Louis International Airport

    1. Take the bus from Manhattan KS to Salinabus bus
    2. Fly from Salina Municipal Airport (SLN) to Lambert–St. Louis International Airport (STL)plane plane SLN - STL
    8h 20m
    $135–638

Manhattan to St. Louis by bus (Greyhound)

Calendar7Weekly Buses
Duration8h 5mAverage Duration
Ticket$60Cheapest Price
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Questions & Answers

Map of how to get from Manhattan to St. Louis.ExpandLaunch map view
  • Distance: 398.2 mi
  • Duration: 8h 5m

What companies run services between Manhattan, KS, USA and St. Louis, MO, USA?

Greyhound USA operates a bus from Manhattan KS to St Louis Bus Station once daily. Tickets cost $60–120 and the journey takes 8h 5m. Alternatively, American Airlines flies from Manhattan Regional Airport (MHK) to Lambert–St. Louis International Airport (STL) 4 times a day.

Airlines
Train operators
Bus operators

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