There are 12 ways to get from Manhattan to Cape Girardeau by plane, bus, bus (Greyhound), train, taxi, or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly Laguardia Airport to Lambert–St. Louis International Airport, bus
best- Fly from Laguardia Airport (LGA) to Lambert–St. Louis International Airport (STL)plane LGA - STL
- Take the bus from St Louis Bus Station to Cape Girardeaubus
8h$171–488Fly Laguardia Airport to Cape Girardeau Municipal Airport
cheapest- Fly from Laguardia Airport (LGA) to Cape Girardeau Municipal Airport (CGI)plane LGA - CGI
7h 20m$146–685Bus (Greyhound)
- Take the bus from Port Authority Bus Terminal to St Louis Bus Stationbus Greyhound US0421
- Take the bus from St Louis Bus Station to Cape Girardeaubus Greyhound US1173
26h 9m$195–301Train, taxi
- Take the train from 125th Street - Harlem to Croton-Harmontrain
- Take the train from Croton-Harmon Amtrak Station to Chicago Union Stationtrain
- Take the train from Chicago Union Station to Carbondaletrain
- Take the taxi from Carbondale to Cape Girardeautaxi
28h 18m$445–1,016Drive 988.2 mi
- Drive from Manhattan to Cape Girardeaucar 988.2 mi
17h 45m$181–261Bus to Newark Liberty International Airport, fly to Lambert–St. Louis International Airport, bus
- Take the bus from Port Authority Bus Terminal to Terminal Bbus
- Fly from Newark Liberty International Airport (EWR) to Lambert–St. Louis International Airport (STL)plane EWR - STL
- Take the bus from St Louis Bus Station to Cape Girardeaubus
8h 9m$343–1,006Bus to Newark Liberty International Airport, fly to Cape Girardeau Municipal Airport
- Take the bus from Port Authority Bus Terminal to Terminal Bbus
- Fly from Newark Liberty International Airport (EWR) to Cape Girardeau Municipal Airport (CGI)plane EWR - CGI
7h 47m$148–593Fly Laguardia Airport to Nashville, bus, taxi
- Fly from Laguardia Airport (LGA) to Nashville (BNA)plane LGA - BNA
- Take the bus from Nashville Bus Station to Carbondale Intermodal Stationbus
- Take the taxi from Carbondale Intermodal Station to Cape Girardeautaxi
10h 22m$245–839Bus to Newark Liberty International Airport, fly to Nashville, bus, taxi
- Take the bus from Port Authority Bus Terminal to Terminal Bbus
- Fly from Newark Liberty International Airport (EWR) to Nashville (BNA)plane EWR - BNA
- Take the bus from Nashville Bus Station to Carbondale Intermodal Stationbus
- Take the taxi from Carbondale Intermodal Station to Cape Girardeautaxi
10h 35m$627–1,747Fly Laguardia Airport to Memphis, bus
- Fly from Laguardia Airport (LGA) to Memphis (MEM)plane LGA - MEM
- Take the bus from Memphis Bus Station to Cape Girardeaubus
10h 2m$260–1,262Fly John F. Kennedy International Airport to Nashville, bus, taxi
- Fly from John F. Kennedy International Airport (JFK) to Nashville (BNA)plane JFK - BNA
- Take the bus from Nashville Bus Station to Carbondale Intermodal Stationbus
- Take the taxi from Carbondale Intermodal Station to Cape Girardeautaxi
10h 41m$596–1,300Train, bus
- Take the train from Ny Moynihan Train Hall At Penn Station to Chicago Union Stationtrain
- Take the train from Chicago Union Station to St. Louistrain
- Take the bus from St Louis Bus Station to Cape Girardeaubus
29h 57m$363–945
Laguardia Airport (LGA) to Lambert–St. Louis International Airport (STL) flights
Comparing Your Travel Options
The cheapest way to get from Manhattan to Cape Girardeau is to drive which costs $180 - $260 and takes 17h 45m.
The fastest way to get from Manhattan to Cape Girardeau is to fly which takes 7h 20m and costs $140 - $700.
No, there is no direct bus from Manhattan to Cape Girardeau. However, there are services departing from Port Authority Bus Terminal and arriving at Cape Girardeau via St Louis Bus Station. The journey, including transfers, takes approximately 26h 9m.
The distance between Manhattan and Cape Girardeau is 1029 miles. The road distance is 993.9 miles.
The best way to get from Manhattan to Cape Girardeau without a car is to bus which takes 26h 9m and costs $190 - $310.
It takes approximately 8h to get from Manhattan to Cape Girardeau, including transfers.
Manhattan to Cape Girardeau bus services, operated by Greyhound USA, depart from Port Authority Bus Terminal station.
The best way to get from Manhattan to Cape Girardeau is to bus which takes 26h 9m and costs $190 - $310. Alternatively, you can fly, which costs $140 - $700 and takes 7h 20m.
Manhattan to Cape Girardeau bus services, operated by Greyhound USA, arrive at St Louis Bus Station.
Cape Girardeau is 1h behind Manhattan. It is currently 2:06 AM in Manhattan and 1:06 AM in Cape Girardeau.
What companies run services between Manhattan, NY, USA and Cape Girardeau, MO, USA?
You can take a bus from Port Authority Bus Terminal to Cape Girardeau via St Louis Bus Station and Cape Girardeau in around 26h 9m. Alternatively, United Airlines, Corporate Flight Management Inc, and American Airlines fly from Laguardia Airport (LGA) to Cape Girardeau Municipal Airport (CGI) twice daily.
- Website
- delta.com
Flights from Laguardia Airport to Lambert–St. Louis International Airport
- Ave. Duration
- 2h 48m
- When
- Every day
- Estimated price
- $140–800
Flights from Newark Liberty International Airport to Lambert–St. Louis International Airport via Detroit
- Ave. Duration
- 5h 6m
- When
- Every day
- Estimated price
- $120–650
Flights from Laguardia Airport to Nashville
- Ave. Duration
- 2h 35m
- When
- Every day
- Estimated price
- $110–650
Flights from Laguardia Airport to Memphis
- Ave. Duration
- 2h 58m
- When
- Every day
- Estimated price
- $220–1,200
Flights from Laguardia Airport to Memphis via Atlanta
- Ave. Duration
- 4h 51m
- When
- Every day
- Estimated price
- $250–1,300
Flights from Laguardia Airport to Memphis via Detroit
- Ave. Duration
- 4h 51m
- When
- Every day
- Estimated price
- $250–1,300
Flights from John F. Kennedy International Airport to Nashville
- Ave. Duration
- 2h 45m
- When
- Every day
- Estimated price
- $80–440
- Website
- southwest.com
Flights from Laguardia Airport to Lambert–St. Louis International Airport
- Ave. Duration
- 2h 40m
- When
- Every day
- Estimated price
- $140–800
Flights from Laguardia Airport to Lambert–St. Louis International Airport via Chicago Midway
- Ave. Duration
- 4h 32m
- When
- Tuesday to Friday
- Estimated price
- $150–800
Flights from Laguardia Airport to Nashville
- Ave. Duration
- 2h 24m
- When
- Every day
- Estimated price
- $110–650
Flights from Laguardia Airport to Memphis via Nashville
- Ave. Duration
- 4h 20m
- When
- Sunday
- Estimated price
- $230–1,200
- Website
- united.com
Flights from Laguardia Airport to Lambert–St. Louis International Airport via Toronto
- Ave. Duration
- 4h 32m
- When
- Every day
- Estimated price
- $160–800
Flights from Newark Liberty International Airport to Lambert–St. Louis International Airport
- Ave. Duration
- 2h 43m
- When
- Every day
- Estimated price
- $120–650
Flights from Newark Liberty International Airport to Lambert–St. Louis International Airport via Washington Dulles
- Ave. Duration
- 5h 3m
- When
- Every day
- Estimated price
- $120–650
Flights from Newark Liberty International Airport to Lambert–St. Louis International Airport via Toronto
- Ave. Duration
- 5h 10m
- When
- Every day
- Estimated price
- $130–650
Flights from Newark Liberty International Airport to Nashville
- Ave. Duration
- 2h 31m
- When
- Every day
- Estimated price
- $90–500
Flights from Newark Liberty International Airport to Nashville via Washington Dulles
- Ave. Duration
- 4h 41m
- When
- Every day
- Estimated price
- $95–550
- Website
- aa.com
Flights from Laguardia Airport to Lambert–St. Louis International Airport
- Ave. Duration
- 2h 52m
- When
- Every day
- Estimated price
- $140–800
Flights from Laguardia Airport to Nashville
- Ave. Duration
- 2h 38m
- When
- Every day
- Estimated price
- $110–650
Flights from Laguardia Airport to Memphis
- Ave. Duration
- 3h 4m
- When
- Every day
- Estimated price
- $220–1,200
Flights from Laguardia Airport to Memphis via Charlotte
- Ave. Duration
- 4h 50m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $240–1,200
Flights from Laguardia Airport to Memphis via Reagan Washington
- Ave. Duration
- 4h 52m
- When
- Sunday
- Estimated price
- $230–1,200
Flights from John F. Kennedy International Airport to Nashville
- Ave. Duration
- 2h 46m
- When
- Every day
- Estimated price
- $80–440
- Website
- aircanada.com
Flights from Laguardia Airport to Lambert–St. Louis International Airport via Toronto
- Ave. Duration
- 4h 32m
- When
- Every day
- Estimated price
- $160–800
Flights from Newark Liberty International Airport to Lambert–St. Louis International Airport via Toronto
- Ave. Duration
- 5h 10m
- When
- Every day
- Estimated price
- $130–650
- Website
- contouraviation.com
Flights from Laguardia Airport to Cape Girardeau Municipal Airport via Chicago O'Hare
- Ave. Duration
- 5h 40m
- When
- Every day
- Estimated price
- $120–650
Flights from Laguardia Airport to Cape Girardeau Municipal Airport via Dallas/Ft.Worth
- Ave. Duration
- 7h 36m
- When
- Monday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $190–850
Flights from Newark Liberty International Airport to Cape Girardeau Municipal Airport via Chicago O'Hare
- Ave. Duration
- 5h 55m
- When
- Every day
- Estimated price
- $100–500
Flights from Newark Liberty International Airport to Cape Girardeau Municipal Airport via Dallas/Ft.Worth
- Ave. Duration
- 7h 3m
- When
- Monday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $150–700
- Website
- jetblue.com
Flights from John F. Kennedy International Airport to Nashville
- Ave. Duration
- 2h 35m
- When
- Every day
- Estimated price
- $80–440
- Phone
- +1 877.690.5114
- Website
- Metro North Railroad
Train from 125th Street - Harlem to Croton-Harmon
- Ave. Duration
- 1h 2m
- Frequency
- Every 20 minutes
- Estimated price
- $10–17
- Website
- Metro North Railroad
- Schedules at
- Metro North Railroad Schedules
- Off-Peak
- $10–12
- Peak
- $14–17
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Croton-Harmon Amtrak Station to Chicago Union Station
- Ave. Duration
- 18h 46m
- Frequency
- Once daily
- Estimated price
- $250–650
- Website
- Amtrak
Train from Chicago Union Station to Carbondale
- Ave. Duration
- 5h 30m
- Frequency
- 3 times a day
- Estimated price
- $85–220
- Website
- Amtrak
Train from Ny Moynihan Train Hall At Penn Station to Chicago Union Station
- Ave. Duration
- 19h 32m
- Frequency
- Once daily
- Estimated price
- $260–700
- Website
- Amtrak
Train from Chicago Union Station to St. Louis
- Ave. Duration
- 4h 46m
- Frequency
- 5 times a day
- Estimated price
- $75–200
- Website
- Amtrak
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from St Louis Bus Station to Cape Girardeau
- Ave. Duration
- 2h 5m
- Frequency
- Once daily
- Estimated price
- $18–29
- Website
- Greyhound
Bus from Port Authority Bus Terminal to St Louis Bus Station
- Ave. Duration
- 23h
- Frequency
- 3 times a day
- Estimated price
- $170–270
- Website
- Greyhound
Bus from St Louis Bus Station to Cape Girardeau
- Ave. Duration
- 2h 5m
- Frequency
- Once daily
- Estimated price
- $18–29
- Website
- Greyhound
Bus from St Louis Bus Station to Cape Girardeau
- Ave. Duration
- 2h 5m
- Frequency
- Once daily
- Estimated price
- $18–29
- Website
- Greyhound
Bus from Memphis Bus Station to Cape Girardeau
- Ave. Duration
- 3h 15m
- Frequency
- Once daily
- Estimated price
- $29–45
- Website
- Greyhound
Bus from St Louis Bus Station to Cape Girardeau
- Ave. Duration
- 2h 5m
- Frequency
- Once daily
- Estimated price
- $18–29
- Website
- Greyhound
- Phone
- +1 (866) 912-6224
- [email protected]
- Website
- newarkairportexpress.com
Bus from Port Authority Bus Terminal to Terminal B
- Ave. Duration
- 40 min
- Frequency
- Every 30 minutes
- Estimated price
- $25
- Book at
- Coach USA
- One Way - Adult
- $25
Bus from Port Authority Bus Terminal to Terminal B
- Ave. Duration
- 40 min
- Frequency
- Every 30 minutes
- Estimated price
- $25
- Book at
- Coach USA
- One Way - Adult
- $25
Bus from Port Authority Bus Terminal to Terminal B
- Ave. Duration
- 40 min
- Frequency
- Every 30 minutes
- Estimated price
- $25
- Book at
- Coach USA
- One Way - Adult
- $25
- Phone
- +1 610-868-6001
- [email protected]
- Website
- transbridgelines.com
Bus from Port Authority Bus Terminal to Terminal B
- Ave. Duration
- 30 min
- Frequency
- 5 times a day
- Estimated price
- $60–66
- Schedules at
- transbridgelines.com
- Adult
- $60–66
Bus from Port Authority Bus Terminal to Terminal B
- Ave. Duration
- 30 min
- Frequency
- 5 times a day
- Estimated price
- $60–66
- Schedules at
- transbridgelines.com
- Adult
- $60–66
Bus from Port Authority Bus Terminal to Terminal B
- Ave. Duration
- 30 min
- Frequency
- 5 times a day
- Estimated price
- $60–66
- Schedules at
- transbridgelines.com
- Adult
- $60–66
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Nashville Bus Station to Carbondale Intermodal Station
- Ave. Duration
- 3h 55m
- Frequency
- 5 times a week
- Estimated price
- $30–50
- Schedules at
- Flixbus USA
Bus from Nashville Bus Station to Carbondale Intermodal Station
- Ave. Duration
- 3h 55m
- Frequency
- 5 times a week
- Estimated price
- $30–50
- Schedules at
- Flixbus USA
Bus from Nashville Bus Station to Carbondale Intermodal Station
- Ave. Duration
- 3h 55m
- Frequency
- 5 times a week
- Estimated price
- $30–50
- Schedules at
- Flixbus USA
- Ave. Duration
- 1h
- Estimated price
- $100–130
Ace Taxi
- Phone
- +1 216-361-4700
- Website
- acetaxi.com
Ace Taxi
- Phone
- +1 216-361-4700
- Website
- acetaxi.com
Ace Taxi
- Phone
- +1 216-361-4700
- Website
- acetaxi.com
Ace Taxi
- Phone
- +1 216-361-4700
- Website
- acetaxi.com
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Booking & Getting There
Yes, the driving distance between Manhattan to Cape Girardeau is 994 miles. It takes approximately 17h 45m to drive from Manhattan to Cape Girardeau.
Book your Manhattan to Cape Girardeau bus tickets online with Omio.
There are 25+ hotels available in Cape Girardeau.















