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How to get fromManhattan to Cleveland Clinicby bus, plane, train (Amtrak), car, train, or bus (Greyhound)

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There are 8 ways to get from Manhattan to Cleveland Clinic by bus, plane, train (Amtrak), car, train, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Newark Liberty International Airport, fly

    best
    1. Take the bus from Port Authority Bus Terminal to Terminal Bbus bus
    2. Fly from Newark Liberty International Airport (EWR) to Cleveland-Hopkins International Airport (CLE)plane plane EWR - CLE
    4h 21m
    $198–918

  2. Bus via Brookpark Station (Greyhound)

    cheapest
    1. Take the bus from Port Authority Bus Terminal to Cleveland Bus Stationbus bus Greyhound US0420
    14h 26m
    $82–150

  3. Bus

    1. Take the bus from New York to Cleveland, OHbus bus New York
    11h 10m
    $96–100

  4. Train (Amtrak)

    1. Take the train from Ny Moynihan Train Hall At Penn Station to Cleveland Amtraktrain train Lake Shore Limited
    13h 14m
    $172–373

  5. Drive 453.5 mi

    1. Drive from Manhattan to Cleveland Cliniccar car 453.5 mi
    8h 7m
    $83–120

  6. Bus to Laguardia Airport, fly

    1. Take the bus from E 125 St/Lexington Av to Laguardia Rd/94 Stbus bus
    2. Fly from Laguardia Airport (LGA) to Cleveland-Hopkins International Airport (CLE)plane plane LGA - CLE
    4h 21m
    $126–450

  7. Train to John F. Kennedy International Airport, fly

    1. Take the train from Grand Central Terminal to Jamaicatrain train
    2. Fly from John F. Kennedy International Airport (JFK) to Cleveland-Hopkins International Airport (CLE)plane plane JFK - CLE
    4h 29m
    $457–971

  8. Train to Philadelphia International Airport, fly

    1. Take the train from Ny Moynihan Train Hall At Penn Station to 30th Street Stationtrain train
    2. Fly from Philadelphia International Airport (PHL) to Cleveland-Hopkins International Airport (CLE)plane plane PHL - CLE
    5h 46m
    $197–1,032

Manhattan to Cleveland Clinic by bus, foot, and subway (Greyhound)

Calendar7Weekly Services
Duration14h 26mAverage Duration
Ticket$82Cheapest Price
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Questions & Answers

Map of how to get from Manhattan to Cleveland Clinic.ExpandLaunch map view
  • Distance: 481.8 mi
  • Duration: 4h 21m

What companies run services between Manhattan, NY, USA and Cleveland Clinic, OH, USA?

Great Wall Bus operates a bus from New York to Cleveland, OH once daily. Tickets cost $90 and the journey takes 8h 30m. Alternatively, Amtrak operates a train from Ny Moynihan Train Hall At Penn Station to Cleveland Amtrak once daily. Tickets cost $160–370 and the journey takes 12h 13m.

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