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How to get fromManhattan to Cleveland Clinicby train, plane, bus, train (Amtrak), car, or bus (Greyhound)

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There are 8 ways to get from Manhattan to Cleveland Clinic by train, plane, bus, train (Amtrak), car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Newark Liberty International Airport, fly

    best
    1. Take the train from New York Penn Station to Newark Airport Railroad Stationtrain train
    2. Fly from Newark Liberty International Airport (EWR) to Cleveland-Hopkins International Airport (CLE)plane plane EWR - CLE
    4h 12m
    $203–880

  2. Drive 453.3 mi

    cheapest
    1. Drive from Manhattan to Cleveland Cliniccar car 453.3 mi
    8h 8m
    $83–120

  3. Bus

    1. Take the bus from New York to Cleveland, OHbus bus New York
    10h 51m
    $96–100

  4. Train (Amtrak)

    1. Take the train from Ny Moynihan Train Hall At Penn Station to Cleveland Amtraktrain train Lake Shore Limited
    13h 14m
    $206–409

  5. Bus to Laguardia Airport, fly

    1. Take the bus from E 125 St/Lexington Av to Laguardia Rd/94 Stbus bus
    2. Fly from Laguardia Airport (LGA) to Cleveland-Hopkins International Airport (CLE)plane plane LGA - CLE
    4h 18m
    $126–710

  6. Train to John F. Kennedy International Airport, fly

    1. Take the train from Grand Central Terminal to Jamaicatrain train
    2. Fly from John F. Kennedy International Airport (JFK) to Cleveland-Hopkins International Airport (CLE)plane plane JFK - CLE
    4h 35m
    $517–971

  7. Train to Philadelphia International Airport, fly

    1. Take the train from Ny Moynihan Train Hall At Penn Station to 30th Street Stationtrain train
    2. Fly from Philadelphia International Airport (PHL) to Cleveland-Hopkins International Airport (CLE)plane plane PHL - CLE
    5h 50m
    $197–1,032

  8. Bus via Brookpark Station (Greyhound)

    1. Take the bus from Port Authority Bus Terminal to Cleveland Bus Stationbus bus Greyhound US0420
    14h 26m
    $93–169

Manhattan to Cleveland Clinic by bus, foot, and subway (Greyhound)

Calendar7Weekly Services
Duration14h 26mAverage Duration
Ticket$93Cheapest Price
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Questions & Answers

Map of how to get from Manhattan to Cleveland Clinic.ExpandLaunch map view
  • Distance: 433.8 mi
  • Duration: 4h 12m

What companies run services between Manhattan, NY, USA and Cleveland Clinic, OH, USA?

Great Wall Bus operates a bus from New York to Cleveland, OH once daily. Tickets cost $90 and the journey takes 8h 30m. Alternatively, Amtrak operates a train from Ny Moynihan Train Hall At Penn Station to Cleveland Amtrak once daily. Tickets cost $200–410 and the journey takes 12h 13m.

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