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How to get fromManhattan to Des Moinesby bus, plane, bus (Flixbus, Greyhound), train, car, or bus (Greyhound)

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There are 8 ways to get from Manhattan to Des Moines by bus, plane, bus (Flixbus, Greyhound), train, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Newark Liberty International Airport, fly

    best
    1. Take the bus from Port Authority Bus Terminal to Terminal Bbus bus
    2. Fly from Newark Liberty International Airport (EWR) to Des Moines (DSM)plane plane EWR - DSM
    4h 46m
    $202–886

  2. Bus

    cheapest
    1. Take the bus from New York Midtown to Chicago Bus Stationbus bus FlixBus N2641 / ...
    2. Take the bus from Chicago Bus Station to Des Moinesbus bus Greyhound US0123S / ...
    24h 25m
    $182–319

  3. Train, bus

    1. Take the train from Ny Moynihan Train Hall At Penn Station to Chicago Union Stationtrain train Lake Shore Limited / ...
    2. Take the bus from Chicago Bus Station to Des Moinesbus bus Greyhound US0123S / ...
    28h 41m
    $303–717

  4. Drive  1,108 mi

    1. Drive from Manhattan to Des Moinescar car 1,108 mi
    18h 27m
    $203–293

  5. Fly from Laguardia Airport

    1. Fly from Laguardia Airport (LGA) to Des Moines (DSM)plane plane LGA - DSM
    4h 41m
    $220–1,028

  6. Train to Philadelphia International Airport, fly

    1. Take the train from Ny Moynihan Train Hall At Penn Station to 30th Street Stationtrain train
    2. Fly from Philadelphia International Airport (PHL) to Des Moines (DSM)plane plane PHL - DSM
    5h 59m
    $251–1,720

  7. Bus via Indianapolis (Greyhound)

    1. Take the bus from Port Authority Bus Terminal to Indianapolis Union Stationbus bus Greyhound US0421
    2. Take the bus from Indianapolis Union Station to Des Moinesbus bus Greyhound US0157S
    28h
    $199–398

  8. Train, bus via Galesburg

    1. Take the train from 125th Street - Harlem to Croton-Harmontrain train
    2. Take the train from Croton-Harmon Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Galesburg Amtrak Stationtrain train
    4. Take the bus from Galesburg to Des Moinesbus bus
    30h 18m
    $320–731

Manhattan to Des Moines by bus

Calendar15Weekly Buses
Duration24h 25mAverage Duration
Ticket$182Cheapest Price
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Questions & Answers

Map of how to get from Manhattan to Des Moines.ExpandLaunch map view
  • Distance: 1,081.8 mi
  • Duration: 4h 46m

What companies run services between Manhattan, NY, USA and Des Moines, IA, USA?

You can take a bus from New York Midtown to Des Moines via Chicago Bus Station in around 24h 25m. Alternatively, American Airlines, Delta, and two other airlines fly from Laguardia Airport (LGA) to Des Moines (DSM) every 2 hours.

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