Rome2Rio

How to get fromManhattan to Des Moinesby bus, plane, bus (Flixbus, Greyhound), train, car, or bus (Greyhound)

Find Transport to Des Moines

See all options

There are 8 ways to get from Manhattan to Des Moines by bus, plane, bus (Flixbus, Greyhound), train, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Newark Liberty International Airport, fly

    best
    1. Take the bus from Port Authority Bus Terminal to Terminal Bbus bus
    2. Fly from Newark Liberty International Airport (EWR) to Des Moines (DSM)plane plane EWR - DSM
    4h 56m
    $138–588

  2. Bus

    1. Take the bus from New York Midtown to Chicago Bus Stationbus bus FlixBus N2640 / ...
    2. Take the bus from Chicago Bus Station to Des Moinesbus bus Greyhound US0123S / ...
    27h 55m
    $199–307

  3. Train, bus

    1. Take the train from Ny Moynihan Train Hall At Penn Station to Chicago Union Stationtrain train Lake Shore Limited / ...
    2. Take the bus from Chicago Bus Station to Des Moinesbus bus Greyhound US0123S / ...
    28h 41m
    $283–692

  4. Drive  1,108 mi

    1. Drive from Manhattan to Des Moinescar car 1,108 mi
    18h 27m
    $203–293

  5. Fly from Laguardia Airport

    1. Fly from Laguardia Airport (LGA) to Des Moines (DSM)plane plane LGA - DSM
    4h 49m
    $141–680

  6. Train to Philadelphia International Airport, fly

    1. Take the train from Ny Moynihan Train Hall At Penn Station to 30th Street Stationtrain train
    2. Fly from Philadelphia International Airport (PHL) to Des Moines (DSM)plane plane PHL - DSM
    6h
    $151–1,223

  7. Bus #2 (Greyhound)

    1. Take the bus from Port Authority Bus Terminal to Indianapolis Union Stationbus bus Greyhound US0421
    2. Take the bus from Indianapolis Union Station to Des Moinesbus bus Greyhound US0157S
    27h 55m
    $199–320

  8. Train, bus via Galesburg

    1. Take the train from 125th Street - Harlem to Croton-Harmontrain train
    2. Take the train from Croton-Harmon Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Galesburg Amtrak Stationtrain train
    4. Take the bus from Galesburg to Des Moinesbus bus
    30h 18m
    $300–721

Manhattan to Des Moines by bus

Calendar14Weekly Buses
Duration27h 55mAverage Duration
Ticket$199Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Manhattan to Des Moines.ExpandLaunch map view
  • Distance: 1,081.8 mi
  • Duration: 4h 56m

What companies run services between Manhattan, NY, USA and Des Moines, IA, USA?

You can take a bus from New York Midtown to Des Moines via Chicago Bus Station in around 27h 55m. Alternatively, American Airlines, Delta, and two other airlines fly from Laguardia Airport (LGA) to Des Moines (DSM) every 2 hours.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

Booking & Getting There