There are 7 ways to get from Manhattan to Destiny USA by bus (Greyhound), train, car, bus, or plane
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus
best- Take the bus from New York to Syracusebus Adt N816 / ...
4h 54m$45–90Train
- Take the train from New York Penn Station to Syracusetrain VIA Rail
5h 42m$75–240Drive 252.8 mi
- Drive from Manhattan to Destiny USAcar 252.8 mi
4h 38m$47–67Bus to Laguardia Airport, fly to Syracuse Hancock International Airport
- Take the bus from E 125 St/Lexington Av to Laguardia Rd/94 Stbus
- Fly from Laguardia Airport (LGA) to Syracuse Hancock International Airport (SYR)plane LGA - SYR
4h 40m$94–665Train to John F. Kennedy International Airport, fly to Syracuse Hancock International Airport
- Take the train from Grand Central Terminal to Jamaicatrain
- Fly from John F. Kennedy International Airport (JFK) to Syracuse Hancock International Airport (SYR)plane JFK - SYR
4h 54m$85–516Fly Newark Liberty International Airport to Rochester, train
- Fly from Newark Liberty International Airport (EWR) to Rochester (ROC)plane EWR - ROC
- Take the train from Rochester to Syracuse Regional Transportation Centertrain
5h 24m$529–1,809Fly Laguardia Airport to Rochester, train
- Fly from Laguardia Airport (LGA) to Rochester (ROC)plane LGA - ROC
- Take the train from Rochester to Syracuse Regional Transportation Centertrain
5h 31m$132–789
Manhattan to Destiny USA by bus and foot
Questions & Answers
The cheapest way to get from Manhattan to Destiny USA is to bus which costs $45 - $90 and takes 4h 54m.
The fastest way to get from Manhattan to Destiny USA is to drive which takes 4h 38m and costs $45 - $70.
Yes, there is a direct bus departing from New York and arriving at Syracuse. Services depart every two hours, and operate every day. The journey takes approximately 4h 45m.
Yes, there is a direct train departing from New York Penn Station station and arriving at Syracuse. Services depart once daily, and operate every day. The journey takes approximately 5h 33m.
The distance between Manhattan and Destiny USA is 301 miles. The road distance is 254.3 miles.
The best way to get from Manhattan to Destiny USA without a car is to bus which takes 4h 54m and costs $45 - $90.
The bus from New York to Syracuse takes 4h 45m including transfers and departs every two hours.
Manhattan to Destiny USA bus services, operated by Trailways, depart from New York station.
Manhattan to Destiny USA train services, operated by VIA Rail, depart from New York Penn Station.
The best way to get from Manhattan to Destiny USA is to bus which takes 4h 54m and costs $45 - $90. Alternatively, you can train, which costs $75 - $240 and takes 5h 42m.
What companies run services between Manhattan, NY, USA and Destiny USA, NY, USA?
Trailways operates a bus from New York to Syracuse every 4 hours. Tickets cost $40–180 and the journey takes 4h 45m. Greyhound USA also services this route every 4 hours. Alternatively, VIA Rail operates a train from New York Penn Station to Syracuse once daily. Tickets cost $75–240 and the journey takes 5h 33m.
- Website
- delta.com
Flights from Laguardia Airport to Syracuse Hancock International Airport
- Ave. Duration
- 1h 28m
- When
- Every day
- Estimated price
- $90–650
Flights from John F. Kennedy International Airport to Syracuse Hancock International Airport
- Ave. Duration
- 1h 37m
- When
- Every day
- Estimated price
- $70–490
Flights from Laguardia Airport to Rochester
- Ave. Duration
- 1h 33m
- When
- Every day
- Estimated price
- $90–600
- Website
- united.com
Flights from Newark Liberty International Airport to Rochester
- Ave. Duration
- 1h 26m
- When
- Every day
- Estimated price
- $70–470
Flights from Newark Liberty International Airport to Rochester via Washington Dulles
- Ave. Duration
- 3h 38m
- When
- Monday, Wednesday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- $100–600
Flights from Laguardia Airport to Rochester via Washington Dulles
- Ave. Duration
- 3h 43m
- When
- Every day
- Estimated price
- $130–700
- Website
- jetblue.com
Flights from John F. Kennedy International Airport to Syracuse Hancock International Airport
- Ave. Duration
- 1h 33m
- When
- Every day
- Estimated price
- $70–490
- Phone
- +1 888 842-7245
- Website
- viarail.ca
Train from New York Penn Station to Syracuse
- Ave. Duration
- 5h 33m
- Frequency
- Once daily
- Estimated price
- $75–240
- Website
- https://www.viarail.ca/en
- Escape
- $75–180
- Business
- $110–230
- Business Plus
- $120–240
- Economy
- $85–190
- Economy Plus
- $95–200
Train from Rochester to Syracuse Regional Transportation Center
- Ave. Duration
- 1h 15m
- Frequency
- Once daily
- Estimated price
- $21–160
- Website
- https://www.viarail.ca/en
- Escape
- $21–75
- Business
- $50–150
- Business Plus
- $60–160
- Economy
- $24–80
- Economy Plus
- $26–85
Train from Rochester to Syracuse Regional Transportation Center
- Ave. Duration
- 1h 15m
- Frequency
- Once daily
- Estimated price
- $21–160
- Website
- https://www.viarail.ca/en
- Escape
- $21–75
- Business
- $50–150
- Business Plus
- $60–160
- Economy
- $24–80
- Economy Plus
- $26–85
- Phone
- +1-718-217-5477
- Website
- mta.info
Train from Grand Central Terminal to Jamaica
- Ave. Duration
- 21 min
- Frequency
- Every 15 minutes
- Estimated price
- $5–9
- Website
- https://www.mta.info/agency/long-island-rail-road
- Schedules at
- https://www.mta.info/agency/long-island-rail-road/timetables
- Off-Peak
- $5–8
- Peak
- $5–9
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Rochester to Syracuse Regional Transportation Center
- Ave. Duration
- 1h 15m
- Frequency
- 5 times a day
- Estimated price
- $26–55
- Website
- https://www.amtrak.com/home.html
Train from Rochester to Syracuse Regional Transportation Center
- Ave. Duration
- 1h 15m
- Frequency
- 5 times a day
- Estimated price
- $26–55
- Website
- https://www.amtrak.com/home.html
- Phone
- +1 800-858-8555
- Website
- trailways.com
Bus from New York to Syracuse
- Ave. Duration
- 4h 45m
- Frequency
- Every 4 hours
- Estimated price
- $40–180
- Website
- https://trailways.com
- Schedules at
- https://trailways.com/schedules/
- Saver
- $40–170
- Flexible
- $80–180
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- greyhound.com
Bus from New York to Syracuse
- Ave. Duration
- 4h 45m
- Frequency
- Every 4 hours
- Estimated price
- $45–90
- Website
- https://www.greyhound.com/
- Phone
- 877-690-5116
- Website
- mta.info
Bus from E 125 St/Lexington Av to Laguardia Rd/94 St
- Ave. Duration
- 24 min
- Frequency
- Every 10 minutes
- Estimated price
- $3–8
- Website
- https://www.mta.info/
- Schedules at
- https://www.mta.info/schedules
- Website
- https://www.mta.info/world-cup-2026-new-york-new-jersey
- Standard Fare
- $3–8
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Need to know: Greyhound
Read the travel guide
How to get from JFK to New York City
Read the travel guide
More Questions & Answers
Manhattan to Destiny USA bus services, operated by Trailways, arrive at Syracuse station.
Manhattan to Destiny USA train services, operated by VIA Rail, arrive at Syracuse station.
Yes, the driving distance between Manhattan to Destiny USA is 254 miles. It takes approximately 4h 38m to drive from Manhattan to Destiny USA.
Book your Manhattan to Destiny USA train tickets online with Omio.
Book your Manhattan to Destiny USA bus tickets online with Omio and FlixBus.
There are 95+ hotels available in Destiny USA.

















