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How to get fromManhattan to Florenceby plane, bus, bus (Greyhound), train (Amtrak), or car

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There are 9 ways to get from Manhattan to Florence by plane, bus, bus (Greyhound), train (Amtrak), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Laguardia Airport to Myrtle Beach, bus

    best
    1. Fly from Laguardia Airport (LGA) to Myrtle Beach (MYR)plane plane LGA - MYR
    2. Take the bus from Myrtle Beach to Florencebus bus
    6h 14m

  2. Bus

    cheapest
    1. Take the bus from New York, NY to Florence, SCbus bus Nyc
    13h 59m
    $91–140

  3. Bus via Raleigh

    1. Take the bus from Port Authority Bus Terminal to Raleigh Bus Stationbus bus Greyhound US0670 / ...
    2. Take the bus from Raleigh Bus Station to Florence Bus Stationbus bus Greyhound US0642S / ...
    13h 44m
    $109–209

  4. Train (Amtrak)

    1. Take the train from Ny Moynihan Train Hall At Penn Station to Florence Stationtrain train Palmetto / ...
    14h 41m
    $200–420

  5. Drive 629 mi

    1. Drive from Manhattan to Florencecar car 629 mi
    11h 4m
    $115–166

  6. Fly Newark Liberty International Airport to Myrtle Beach, bus

    1. Fly from Newark Liberty International Airport (EWR) to Myrtle Beach (MYR)plane plane EWR - MYR
    2. Take the bus from Myrtle Beach to Florencebus bus
    6h 18m

  7. Fly Newark Liberty International Airport to Charlotte Douglas International Airport, bus

    1. Fly from Newark Liberty International Airport (EWR) to Charlotte Douglas International Airport (CLT)plane plane EWR - CLT
    2. Take the bus from Charlotte Bus Station to Camdenbus bus
    3. Take the bus from Camden to Florencebus bus
    8h 35m
    $273–672

  8. Fly Laguardia Airport to Charlotte Douglas International Airport, bus

    1. Fly from Laguardia Airport (LGA) to Charlotte Douglas International Airport (CLT)plane plane LGA - CLT
    2. Take the bus from Charlotte Bus Station to Camdenbus bus
    3. Take the bus from Camden to Florencebus bus
    8h 41m
    $146–652

  9. Fly Newark Liberty International Airport to Raleigh-Durham International Airport, bus

    1. Fly from Newark Liberty International Airport (EWR) to Raleigh-Durham International Airport (RDU)plane plane EWR - RDU
    2. Take the bus from Raleigh Bus Station to Florence Bus Stationbus bus
    9h 10m
    $289–1,282

Manhattan to Florence by bus

Calendar28Weekly Buses
Duration13h 44mAverage Duration
Ticket$109Cheapest Price
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Questions & Answers

Map of how to get from Manhattan to Florence.ExpandLaunch map view
  • Distance: 648.9 mi
  • Duration: 6h 14m

What companies run services between Manhattan, NY, USA and Florence, SC, USA?

You can take a bus from Port Authority Bus Terminal to Florence Bus Station via Raleigh Bus Station in around 13h 44m. Alternatively, Amtrak operates a train from Ny Moynihan Train Hall At Penn Station to Florence Station twice daily. Tickets cost $200–420 and the journey takes 14h 41m.

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