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How to get fromManhattan to Florenceby plane, bus, bus (Greyhound), train (Amtrak), or car

Find Transport to Florence

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There are 8 ways to get from Manhattan to Florence by plane, bus, bus (Greyhound), train (Amtrak), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Laguardia Airport to Myrtle Beach, bus

    best
    1. Fly from Laguardia Airport (LGA) to Myrtle Beach (MYR)plane plane LGA - MYR
    2. Take the bus from Myrtle Beach Bus Station to Florence Bus Stationbus bus
    6h 17m
    $101–490

  2. Bus

    cheapest
    1. Take the bus from New York, NY to Florence, SCbus bus Nyc
    13h 59m
    $91–140

  3. Bus via Raleigh (Greyhound)

    1. Take the bus from Port Authority Bus Terminal to Raleigh Bus Stationbus bus Greyhound US0670 / ...
    2. Take the bus from Raleigh Bus Station to Florence Bus Stationbus bus Greyhound US0642S / ...
    13h 35m
    $127–190

  4. Train (Amtrak)

    1. Take the train from Ny Moynihan Train Hall At Penn Station to Florence Stationtrain train Palmetto / ...
    14h 41m
    $340–550

  5. Drive  629 mi

    1. Drive from Manhattan to Florencecar car 629 mi
    11h 4m
    $108–156

  6. Bus to Newark Liberty International Airport, fly to Myrtle Beach, bus

    1. Take the bus from Port Authority Bus Terminal to Terminal Bbus bus
    2. Fly from Newark Liberty International Airport (EWR) to Myrtle Beach (MYR)plane plane EWR - MYR
    3. Take the bus from Myrtle Beach Bus Station to Florence Bus Stationbus bus
    6h 32m
    $108–458

  7. Fly Westchester County Airport to Myrtle Beach, bus

    1. Fly from Westchester County Airport (HPN) to Myrtle Beach (MYR)plane plane HPN - MYR
    2. Take the bus from Myrtle Beach Bus Station to Florence Bus Stationbus bus
    8h 6m
    $154–749

  8. Fly Laguardia Airport to Charlotte Douglas International Airport, bus

    1. Fly from Laguardia Airport (LGA) to Charlotte Douglas International Airport (CLT)plane plane LGA - CLT
    2. Take the bus from Charlotte Bus Station to Camdenbus bus
    3. Take the bus from Camden to Florence Bus Stationbus bus
    8h 52m
    $150–599

Manhattan to Florence by bus (Greyhound)

Calendar28Weekly Buses
Duration13h 35mAverage Duration
Ticket$127Cheapest Price
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Comparing Your Travel Options

Map of how to get from Manhattan to Florence.ExpandLaunch map view
  • Distance: 640.9 mi
  • Duration: 6h 17m

What companies run services between Manhattan, NY, USA and Florence, SC, USA?

You can take a bus from Port Authority Bus Terminal to Florence Bus Station via Raleigh Bus Station in around 13h 35m. Alternatively, Amtrak operates a train from Ny Moynihan Train Hall At Penn Station to Florence Station twice daily. Tickets cost $340–550 and the journey takes 14h 41m.

Airlines
Train operators
Bus operators

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Need to know: Greyhound

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