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How to get fromManhattan to Florenceby plane, bus, train (Amtrak), car, train, or bus (Flixbus, Greyhound)

Find Transport to Florence

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There are 8 ways to get from Manhattan to Florence by plane, bus, train (Amtrak), car, train, or bus (Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Laguardia Airport to Myrtle Beach, bus

    best
    1. Fly from Laguardia Airport (LGA) to Myrtle Beach (MYR)plane plane LGA - MYR
    2. Take the bus from Myrtle Beach Bus Station to Florence Bus Stationbus bus
    6h 13m
    $100–489

  2. Bus

    cheapest
    1. Take the bus from New York, NY to Florence, SCbus bus Nyc
    13h 59m
    $91–140

  3. Train (Amtrak)

    1. Take the train from Ny Moynihan Train Hall At Penn Station to Florence Stationtrain train Palmetto / ...
    14h 41m
    $350–550

  4. Drive  629 mi

    1. Drive from Manhattan to Florencecar car 629 mi
    11h 4m
    $115–166

  5. Bus to Newark Liberty International Airport, fly to Myrtle Beach, bus

    1. Take the bus from Port Authority Bus Terminal to Terminal Bbus bus
    2. Fly from Newark Liberty International Airport (EWR) to Myrtle Beach (MYR)plane plane EWR - MYR
    3. Take the bus from Myrtle Beach Bus Station to Florence Bus Stationbus bus
    6h 25m
    $397–697

  6. Fly Laguardia Airport to Charleston International Airport, train

    1. Fly from Laguardia Airport (LGA) to Charleston International Airport (CHS)plane plane LGA - CHS
    2. Take the train from Charleston Amtrak Station to Florence Stationtrain train
    8h 26m
    $167–746

  7. Fly Laguardia Airport to Charlotte Douglas International Airport, bus

    1. Fly from Laguardia Airport (LGA) to Charlotte Douglas International Airport (CLT)plane plane LGA - CLT
    2. Take the bus from Charlotte Bus Station to Camdenbus bus
    3. Take the bus from Camden to Florence Bus Stationbus bus
    8h 43m
    $158–647

  8. Bus via Fayetteville

    1. Take the bus from New York City Chinatown to Fayetteville Bus Stationbus bus FlixBus N2471 / ...
    2. Take the bus from Fayetteville Bus Station to Florence Bus Stationbus bus Greyhound US0642S / ...
    15h 44m
    $108–170

Manhattan to Florence by train (Amtrak)

Calendar14Weekly Trains
Duration14h 41mAverage Duration
Ticket$350Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Manhattan to Florence.ExpandLaunch map view
  • Distance: 640.9 mi
  • Duration: 6h 13m

What companies run services between Manhattan, NY, USA and Florence, SC, USA?

Wanda Coach operates a bus from New York, NY to Florence, SC 3 times a day. Tickets cost $85–130 and the journey takes 12h. Alternatively, Amtrak operates a train from Ny Moynihan Train Hall At Penn Station to Florence Station twice daily. Tickets cost $350–550 and the journey takes 14h 41m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

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