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How to get fromManhattan to Knoxvilleby bus, plane, car, or train

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There are 9 ways to get from Manhattan to Knoxville by bus, plane, car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Newark Liberty International Airport, fly to Mcghee Tyson Airport

    best
    1. Take the bus from Port Authority Bus Terminal to Terminal Bbus bus
    2. Fly from Newark Liberty International Airport (EWR) to Mcghee Tyson Airport (TYS)plane plane EWR - TYS
    3h 47m
    $240–1,085

  2. Fly Laguardia Airport to Asheville Regional Airport, drive

    cheapest
    1. Fly from Laguardia Airport (LGA) to Asheville Regional Airport (AVL)plane plane LGA - AVL
    2. Drive from Asheville-Airport-AVL to Knoxvillecar car
    5h 45m
    $110–542

  3. Bus via Farragut

    1. Take the bus from New York to Knoxvillebus bus Nyc
    13h 25m
    $183–253

  4. Drive  706.4 mi

    1. Drive from Manhattan to Knoxvillecar car 706.4 mi
    12h 6m
    $129–187

  5. Fly Laguardia Airport to Mcghee Tyson Airport

    1. Fly from Laguardia Airport (LGA) to Mcghee Tyson Airport (TYS)plane plane LGA - TYS
    4h 2m
    $268–1,277

  6. Train to Philadelphia International Airport, fly to Mcghee Tyson Airport

    1. Take the train from Ny Moynihan Train Hall At Penn Station to 30th Street Stationtrain train
    2. Fly from Philadelphia International Airport (PHL) to Mcghee Tyson Airport (TYS)plane plane PHL - TYS
    5h 19m
    $258–1,770

  7. Fly Laguardia Airport to Chattanooga Metropolitan Airport, drive

    1. Fly from Laguardia Airport (LGA) to Chattanooga Metropolitan Airport (CHA)plane plane LGA - CHA
    2. Drive from Chattanooga Metropolitan Airport (CHA) to Knoxvillecar car
    5h 39m
    $121–585

  8. Bus to Newark Liberty International Airport, fly to Asheville Regional Airport, drive

    1. Take the bus from Port Authority Bus Terminal to Terminal Bbus bus
    2. Fly from Newark Liberty International Airport (EWR) to Asheville Regional Airport (AVL)plane plane EWR - AVL
    3. Drive from Asheville-Airport-AVL to Knoxvillecar car
    5h 49m
    $117–510

  9. Bus

    1. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    13h 42m
    $138–163

Newark Liberty International Airport (EWR) to Mcghee Tyson Airport (TYS) flights

Calendar64Weekly Planes
Duration3h 39mAverage Duration
Ticket$168Cheapest Price
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Comparing Your Travel Options

Map of how to get from Manhattan to Knoxville.ExpandLaunch map view
  • Distance: 704.7 mi
  • Duration: 3h 47m

What companies run services between Manhattan, NY, USA and Knoxville, TN, USA?

Wanda Coach operates a bus from New York to Knoxville once daily. Tickets cost $95–140 and the journey takes 11h 45m. Alternatively, American Airlines, Delta, and two other airlines fly from Laguardia Airport (LGA) to Mcghee Tyson Airport (TYS) every 2 hours.

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