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How to get fromManhattan to Mayo Clinicby plane, bus (Flixbus, Greyhound), train, bus, car, or bus (Greyhound, Amtrak)

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There are 13 ways to get from Manhattan to Mayo Clinic by plane, bus (Flixbus, Greyhound), train, bus, car, or bus (Greyhound, Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Laguardia Airport to Rochester

    best
    1. Fly from Laguardia Airport (LGA) to Rochester (RST)plane plane LGA - RST
    8h 8m
    $124–697

  2. Bus

    1. Take the bus from New York Midtown to Chicago Bus Stationbus bus
    2. Take the bus from Chicago Bus Station to Milwaukee Intermodal Stationbus bus
    3. Take the bus from Milwaukee to Rochesterbus bus
    29h 53m
    $239–354

  3. Train, bus via Madison

    1. Take the train from Ny Moynihan Train Hall At Penn Station to Chicago Union Stationtrain train
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    30h 48m
    $578–987

  4. Drive  1,138.9 mi

    1. Drive from Manhattan to Mayo Cliniccar car 1,138.9 mi
    18h 56m
    $208–301

  5. Bus to Newark Liberty International Airport, fly to Rochester

    1. Take the bus from Port Authority Bus Terminal to Terminal Bbus bus
    2. Fly from Newark Liberty International Airport (EWR) to Rochester (RST)plane plane EWR - RST
    7h 55m
    $126–605

  6. Fly Laguardia Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Laguardia Airport (LGA) to Minneapolis–Saint Paul International Airport (MSP)plane plane LGA - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 34m
    $293–707

  7. Bus to Newark Liberty International Airport, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the bus from Port Authority Bus Terminal to Terminal Bbus bus
    2. Fly from Newark Liberty International Airport (EWR) to Minneapolis–Saint Paul International Airport (MSP)plane plane EWR - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 42m
    $255–965

  8. Fly John F. Kennedy International Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from John F. Kennedy International Airport (JFK) to Minneapolis–Saint Paul International Airport (MSP)plane plane JFK - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 47m
    $484–1,068

  9. Fly Westchester County Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Westchester County Airport (HPN) to Minneapolis–Saint Paul International Airport (MSP)plane plane HPN - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    9h 24m
    $271–1,166

  10. Fly Laguardia Airport to Dane County Regional Airport-Truax Field, bus

    1. Fly from Laguardia Airport (LGA) to Dane County Regional Airport-Truax Field (MSN)plane plane LGA - MSN
    2. Take the bus from Madison to Rochesterbus bus
    10h 34m
    $215–934

  11. Bus to Newark Liberty International Airport, fly to Dane County Regional Airport-Truax Field, bus

    1. Take the bus from Port Authority Bus Terminal to Terminal Bbus bus
    2. Fly from Newark Liberty International Airport (EWR) to Dane County Regional Airport-Truax Field (MSN)plane plane EWR - MSN
    3. Take the bus from Madison to Rochesterbus bus
    10h 43m
    $197–842

  12. Bus via Toledo

    1. Take the bus from Port Authority Bus Terminal to Toledo Bus Stopbus bus
    2. Take the bus from Toledo to Chicago Union Stationbus bus
    3. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    4. Take the bus from Madison to Rochesterbus bus
    31h 18m

  13. Train, bus

    1. Take the train from 125th Street - Harlem to Croton-Harmontrain train
    2. Take the train from Croton-Harmon Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    4. Take the bus from St. Paul to Rochesterbus bus
    31h 52m
    $758–1,206

Manhattan to Mayo Clinic by bus and foot

Calendar7Weekly Services
Duration29h 53mAverage Duration
Ticket$239Cheapest Price
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Comparing Your Travel Options

Map of how to get from Manhattan to Mayo Clinic.ExpandLaunch map view
  • Distance: 989.6 mi
  • Duration: 8h 8m

What companies run services between Manhattan, NY, USA and Mayo Clinic, MN, USA?

Delta and American Airlines fly from Laguardia Airport (LGA) to Rochester (RST) every 3 hours. Alternatively, you can take a bus from New York Midtown to Mayo Clinic via Chicago Bus Station, Milwaukee Intermodal Station, Milwaukee, and Rochester in around 29h 53m.

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