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How to get fromManhattan to Mayo Clinicby plane, bus (Flixbus, Greyhound), train, bus, car, or bus (Greyhound)

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There are 11 ways to get from Manhattan to Mayo Clinic by plane, bus (Flixbus, Greyhound), train, bus, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Laguardia Airport to Rochester

    best
    1. Fly from Laguardia Airport (LGA) to Rochester (RST)plane plane LGA - RST
    7h 56m
    $137–628

  2. Fly Newark Liberty International Airport to Rochester

    cheapest
    1. Fly from Newark Liberty International Airport (EWR) to Rochester (RST)plane plane EWR - RST
    8h 4m
    $129–498

  3. Bus

    1. Take the bus from New York Midtown to Chicago Bus Stationbus bus
    2. Take the bus from Chicago Bus Station to Milwaukee Intermodal Stationbus bus
    3. Take the bus from Milwaukee to Rochesterbus bus
    26h 25m
    $280–397

  4. Train, bus via Madison

    1. Take the train from Ny Moynihan Train Hall At Penn Station to Chicago Union Stationtrain train
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    30h 46m
    $388–787

  5. Drive 1,138.7 mi

    1. Drive from Manhattan to Mayo Cliniccar car 1,138.7 mi
    18h 57m
    $208–301

  6. Fly Laguardia Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Laguardia Airport (LGA) to Minneapolis–Saint Paul International Airport (MSP)plane plane LGA - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 16m
    $225–759

  7. Fly Newark Liberty International Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Newark Liberty International Airport (EWR) to Minneapolis–Saint Paul International Airport (MSP)plane plane EWR - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 16m
    $222–929

  8. Fly John F. Kennedy International Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from John F. Kennedy International Airport (JFK) to Minneapolis–Saint Paul International Airport (MSP)plane plane JFK - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 33m
    $486–1,070

  9. Fly Westchester County Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Westchester County Airport (HPN) to Minneapolis–Saint Paul International Airport (MSP)plane plane HPN - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    9h 29m
    $233–868

  10. Train, bus

    1. Take the train from 125th Street - Harlem to Croton-Harmontrain train
    2. Take the train from Croton-Harmon Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    4. Take the bus from St. Paul to Rochester, MNbus bus
    31h 57m
    $468–976

  11. Bus via Baltimore

    1. Take the bus from Port Authority Bus Terminal to Baltimorebus bus
    2. Take the bus from Baltimore Downtown Bus Station to Chicago Bus Stationbus bus
    3. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    4. Take the bus from Madison to Rochesterbus bus
    33h 17m
    $274–433

Manhattan to Mayo Clinic by train, bus, and foot

Calendar7Weekly Services
Duration31h 57mAverage Duration
Ticket$468Cheapest Price
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Questions & Answers

Map of how to get from Manhattan to Mayo Clinic.ExpandLaunch map view
  • Distance: 989.6 mi
  • Duration: 7h 56m

What companies run services between Manhattan, NY, USA and Mayo Clinic, MN, USA?

United Airlines, Delta, and American Airlines fly from Laguardia Airport (LGA) to Rochester (RST) every 2 hours. Alternatively, you can take a bus from New York Midtown to Mayo Clinic via Chicago Bus Station, Milwaukee Intermodal Station, Milwaukee, and Rochester in around 26h 25m.

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