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How to get fromManhattan to St. Louisby plane, bus (Greyhound), train (Amtrak), car, bus, or train

Find Transport to St. Louis

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There are 7 ways to get from Manhattan to St. Louis by plane, bus (Greyhound), train (Amtrak), car, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Laguardia Airport

    best
    1. Fly from Laguardia Airport (LGA) to Lambert–St. Louis International Airport (STL)plane plane LGA - STL
    4h 53m
    $186–560

  2. Train to Philadelphia International Airport, fly

    cheapest
    1. Take the train from Ny Moynihan Train Hall At Penn Station to 30th Street Stationtrain train
    2. Fly from Philadelphia International Airport (PHL) to Lambert–St. Louis International Airport (STL)plane plane PHL - STL
    6h 4m
    $146–1,353

  3. Bus (Greyhound)

    1. Take the bus from Port Authority Bus Terminal to St Louis Bus Stationbus bus Greyhound US0421
    22h 25m
    $180–280

  4. Train

    1. Take the train from 125th Street - Harlem to Croton-Harmontrain train
    2. Take the train from Croton-Harmon Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Louistrain train
    26h 34m
    $660–1,056

  5. Drive  947 mi

    1. Drive from Manhattan to St. Louiscar car 947 mi
    16h 33m
    $173–250

  6. Bus to Newark Liberty International Airport, fly

    1. Take the bus from Port Authority Bus Terminal to Terminal Bbus bus
    2. Fly from Newark Liberty International Airport (EWR) to Lambert–St. Louis International Airport (STL)plane plane EWR - STL
    5h 16m
    $318–968

  7. Train to Long Island Mac Arthur Airport, fly

    1. Take the train from New York Penn Station to Central Isliptrain train
    2. Fly from Long Island Mac Arthur Airport (ISP) to Lambert–St. Louis International Airport (STL)plane plane ISP - STL
    8h 16m
    $179–883

Manhattan to St. Louis by bus (Greyhound)

Calendar21Weekly Buses
Duration22h 25mAverage Duration
Ticket$180Cheapest Price
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Comparing Your Travel Options

Map of how to get from Manhattan to St. Louis.ExpandLaunch map view
  • Distance: 907.1 mi
  • Duration: 4h 53m

What companies run services between Manhattan, NY, USA and St. Louis, MO, USA?

American Airlines, Delta, and Southwest Airlines fly from Laguardia Airport (LGA) to Lambert–St. Louis International Airport (STL) hourly. Alternatively, Greyhound USA operates a bus from Port Authority Bus Terminal to St Louis Bus Station 3 times a day. Tickets cost $180–280 and the journey takes 22h 25m.

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Need to know: Greyhound

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