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How to get fromManhattan to St. Louisby bus, plane, bus (Greyhound), train (Amtrak), car, or train

Find Transport to St. Louis

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There are 8 ways to get from Manhattan to St. Louis by bus, plane, bus (Greyhound), train (Amtrak), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Newark Liberty International Airport, fly

    best
    1. Take the bus from Port Authority Bus Terminal to Terminal Bbus bus
    2. Fly from Newark Liberty International Airport (EWR) to Lambert–St. Louis International Airport (STL)plane plane EWR - STL
    4h 59m
    $318–968

  2. Fly from John F. Kennedy International Airport

    cheapest
    1. Fly from John F. Kennedy International Airport (JFK) to Lambert–St. Louis International Airport (STL)plane plane JFK - STL
    5h 11m
    $127–621

  3. Bus (Greyhound)

    1. Take the bus from Port Authority Bus Terminal to St Louis Bus Stationbus bus Greyhound US0421
    23h
    $160–260

  4. Train (Amtrak)

    1. Take the train from Ny Moynihan Train Hall At Penn Station to Chicago Union Stationtrain train Lake Shore Limited / ...
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    26h 48m
    $298–777

  5. Drive  947 mi

    1. Drive from Manhattan to St. Louiscar car 947 mi
    16h 33m
    $173–250

  6. Fly from Laguardia Airport

    1. Fly from Laguardia Airport (LGA) to Lambert–St. Louis International Airport (STL)plane plane LGA - STL
    4h 54m
    $146–450

  7. Train to Philadelphia International Airport, fly

    1. Take the train from Ny Moynihan Train Hall At Penn Station to 30th Street Stationtrain train
    2. Fly from Philadelphia International Airport (PHL) to Lambert–St. Louis International Airport (STL)plane plane PHL - STL
    6h 4m
    $146–1,353

  8. Train to Long Island Mac Arthur Airport, fly

    1. Take the train from New York Penn Station to Central Isliptrain train
    2. Fly from Long Island Mac Arthur Airport (ISP) to Lambert–St. Louis International Airport (STL)plane plane ISP - STL
    8h 12m
    $159–783

Manhattan to St. Louis by bus (Greyhound)

Calendar21Weekly Buses
Duration23hAverage Duration
Ticket$160Cheapest Price
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Comparing Your Travel Options

Map of how to get from Manhattan to St. Louis.ExpandLaunch map view
  • Distance: 945.6 mi
  • Duration: 4h 59m

What companies run services between Manhattan, NY, USA and St. Louis, MO, USA?

Greyhound USA operates a bus from Port Authority Bus Terminal to St Louis Bus Station 3 times a day. Tickets cost $160–260 and the journey takes 23h. Alternatively, you can take a bus from Columbus Av/W 84 St to St. Louis via 7 Av/W 31 St, Ny Moynihan Train Hall At Penn Station, and Chicago Union Station in around 26h 48m.

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