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How to get fromManhattan to Syracuseby bus (Greyhound, Flixbus), train, car, bus, or plane

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There are 7 ways to get from Manhattan to Syracuse by bus (Greyhound, Flixbus), train, car, bus, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Port Authority Bus Terminal to Syracuse Bus Stationbus bus Greyhound US0205 / ...
    4h 45m
    $40–160

  2. Train

    1. Take the train from New York Penn Station to Syracusetrain train VIA Rail
    5h 33m
    $75–240

  3. Drive 250.2 mi

    1. Drive from Manhattan to Syracusecar car 250.2 mi
    4h 34m
    $46–66

  4. Bus to Laguardia Airport, fly to Syracuse Hancock International Airport

    1. Take the bus from E 125 St/Lexington Av to Laguardia Rd/94 Stbus bus
    2. Fly from Laguardia Airport (LGA) to Syracuse Hancock International Airport (SYR)plane plane LGA - SYR
    4h 31m
    $99–665

  5. Train to John F. Kennedy International Airport, fly to Syracuse Hancock International Airport

    1. Take the train from Grand Central Terminal to Jamaicatrain train
    2. Fly from John F. Kennedy International Airport (JFK) to Syracuse Hancock International Airport (SYR)plane plane JFK - SYR
    4h 43m
    $90–576

  6. Fly Laguardia Airport to Rochester, train

    1. Fly from Laguardia Airport (LGA) to Rochester (ROC)plane plane LGA - ROC
    2. Take the train from Rochester to Syracuse Regional Transportation Centertrain train
    5h 21m
    $137–849

  7. Fly Newark Liberty International Airport to Rochester, train

    1. Fly from Newark Liberty International Airport (EWR) to Rochester (ROC)plane plane EWR - ROC
    2. Take the train from Rochester to Syracuse Regional Transportation Centertrain train
    5h 21m
    $529–1,819

Manhattan to Syracuse by bus

Calendar206Weekly Buses
Duration4h 45mAverage Duration
Ticket$40Cheapest Price
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Questions & Answers

Map of how to get from Manhattan to Syracuse.ExpandLaunch map view
  • Distance: 260.5 mi
  • Duration: 4h 45m

What companies run services between Manhattan, NY, USA and Syracuse, NY, USA?

Greyhound USA operates a bus from Port Authority Bus Terminal to Syracuse Bus Station every 2 hours. Tickets cost $35–75 and the journey takes 4h 45m. Two other operators also service this route. Alternatively, VIA Rail operates a train from New York Penn Station to Syracuse once daily. Tickets cost $75–240 and the journey takes 5h 33m.

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Train operators
Bus operators

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