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How to get fromManhattan to Winston-Salemby plane, bus, train (Amtrak), car, or bus (Greyhound)

Find Transport to Winston-Salem

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There are 8 ways to get from Manhattan to Winston-Salem by plane, bus, train (Amtrak), car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Laguardia Airport to Piedmont Triad International Airport

    best
    1. Fly from Laguardia Airport (LGA) to Piedmont Triad International Airport (GSO)plane plane LGA - GSO
    4h 20m
    $182–1,030

  2. Bus via New York, NY

    cheapest
    1. Take the bus from New York, NY to Winston-Salem, NCbus bus Nyc
    11h 54m
    $83–117

  3. Train (Amtrak)

    1. Take the train from Ny Moynihan Train Hall At Penn Station to High Pointtrain train Crescent / ...
    12h 32m
    $291–447

  4. Drive  537.3 mi

    1. Drive from Manhattan to Winston-Salemcar car 537.3 mi
    10h 16m
    $99–142

  5. Bus to Newark Liberty International Airport, fly to Piedmont Triad International Airport

    1. Take the bus from Port Authority Bus Terminal to Terminal Bbus bus
    2. Fly from Newark Liberty International Airport (EWR) to Piedmont Triad International Airport (GSO)plane plane EWR - GSO
    4h 33m
    $174–888

  6. Fly Laguardia Airport to Charlotte Douglas International Airport, bus

    1. Fly from Laguardia Airport (LGA) to Charlotte Douglas International Airport (CLT)plane plane LGA - CLT
    2. Take the bus from Charlotte Bus Station to Winston Salem(Trans Center)bus bus
    6h 33m
    $149–633

  7. Bus to Newark Liberty International Airport, fly to Charlotte Douglas International Airport, bus

    1. Take the bus from Port Authority Bus Terminal to Terminal Bbus bus
    2. Fly from Newark Liberty International Airport (EWR) to Charlotte Douglas International Airport (CLT)plane plane EWR - CLT
    3. Take the bus from Charlotte Bus Station to Winston Salem(Trans Center)bus bus
    6h 44m
    $331–691

  8. Bus (Greyhound)

    1. Take the bus from Port Authority Bus Terminal to Winston Salem(Trans Center)bus bus Greyhound US0670
    15h 15m
    $100–170

Manhattan to Winston-Salem by train and bus (Amtrak)

Calendar14Weekly Services
Duration12h 32mAverage Duration
Ticket$291Cheapest Price
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Comparing Your Travel Options

Map of how to get from Manhattan to Winston-Salem.ExpandLaunch map view
  • Distance: 490.4 mi
  • Duration: 4h 20m

What companies run services between Manhattan, NY, USA and Winston-Salem, NC, USA?

American Airlines, Delta, and United Airlines fly from Laguardia Airport (LGA) to Piedmont Triad International Airport (GSO) every 2 hours. Alternatively, Wanda Coach operates a bus from New York, NY to Winston-Salem, NC 3 times a day. Tickets cost $80–110 and the journey takes 10h.

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