There are 10 ways to get from Manitowoc to Des Moines by taxi, plane, bus, train, car, or bus (Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Taxi to Appleton International Airport, fly
best- Take the taxi from Manitowoc to Appleton International Airport (ATW)taxi
- Fly from Appleton International Airport (ATW) to Des Moines (DSM)plane ATW - DSM
4h 53m$185–505Drive 400.5 mi
cheapest- Drive from Manitowoc to Des Moinescar 400.5 mi
7h 47m$74–106Bus, train
- Take the bus from Manitowoc, WI to Milwaukeebus
- Take the train from Milwaukee to Chicago Union Stationtrain
- Take the bus from Chicago Bus Station to Des Moinesbus
11h 57m$90–169Bus to Green Bay, fly
- Take the bus from Manitowoc, WI to Green Bay, WI - Transitbus
- Fly from Green Bay (GRB) to Des Moines (DSM)plane GRB - DSM
5h 51m$121–437Bus to General Mitchell International Airport, fly
- Take the bus from Manitowoc, WI to Milwaukeebus
- Fly from General Mitchell International Airport (MKE) to Des Moines (DSM)plane MKE - DSM
7h 5m$109–516Bus, bus to Chicago O'Hare International Airport, fly
- Take the bus from Manitowoc, WI to Milwaukeebus
- Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departuresbus
- Fly from Chicago O'Hare International Airport (ORD) to Des Moines (DSM)plane ORD - DSM
7h$115–364Bus
- Take the bus from Manitowoc, WI to Milwaukeebus
- Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departuresbus
- Take the bus from Chicago Bus Station to Des Moinesbus
13h 39m$112–164Bus, train via Galesburg
- Take the bus from Manitowoc, WI to Milwaukeebus
- Take the train from Milwaukee to Chicago Union Stationtrain
- Take the train from Chicago Union Station to Galesburg Amtrak Stationtrain
- Take the bus from Galesburg to Des Moinesbus
13h 48m$110–249Bus, train via Saint Paul
- Take the bus from Manitowoc, WI to Milwaukeebus
- Take the train from Milwaukee to St. Paul-Minneapolistrain
- Take the bus from Saint Paul Union Depot to Des Moinesbus
14h 10m$134–304Bus via Minneapolis
- Take the bus from Manitowoc to Minneapolis Bus Stationbus Greyhound US0150S
- Take the bus from Minneapolis to Des Moinesbus Jefferson Lines 803 / ...
14h 19m$122–189
Appleton International Airport (ATW) to Des Moines (DSM) flights
Comparing Your Travel Options
The cheapest way to get from Manitowoc to Des Moines is to drive which costs $70 - $110 and takes 7h 47m.
The fastest way to get from Manitowoc to Des Moines is to taxi and fly which takes 4h 53m and costs $180 - $550.
No, there is no direct bus from Manitowoc to Des Moines. However, there are services departing from Manitowoc, WI and arriving at Des Moines via Milwaukee Intermodal/Amtrak Station, Harrison & Kedzie and Chicago Bus Station. The journey, including transfers, takes approximately 13h 39m.
The distance between Manitowoc and Des Moines is 379 miles. The road distance is 402.8 miles.
The best way to get from Manitowoc to Des Moines without a car is to bus and train which takes 11h 57m and costs $90 - $170.
It takes approximately 4h 53m to get from Manitowoc to Des Moines, including transfers.
Manitowoc to Des Moines bus services, operated by Greyhound USA, depart from Manitowoc station.
Manitowoc to Des Moines bus services, operated by Greyhound USA, arrive at Minneapolis Bus Station.
Yes, the driving distance between Manitowoc to Des Moines is 403 miles. It takes approximately 7h 47m to drive from Manitowoc to Des Moines.
Book your Manitowoc to Des Moines bus tickets online with Omio.
What companies run services between Manitowoc, WI, USA and Des Moines, IA, USA?
You can take a vehicle from Manitowoc to Des Moines via Manitowoc, WI, Milwaukee, Milwaukee Intermodal/Amtrak Station, O'Hare International Airport - Terminal 2 Departures, O'Hare, Kedzie-Homan, Harrison & Kedzie, Jefferson & Harrison, and Chicago Bus Station in around 13h 39m.
- Website
- united.com
Flights from Appleton International Airport to Des Moines via Chicago O'Hare International Airport
- Ave. Duration
- 4h 59m
- When
- Every day
- Estimated price
- $55–350
Flights from Appleton International Airport to Des Moines via Denver
- Ave. Duration
- 7h 31m
- When
- Every day
- Estimated price
- $120–550
Flights from Green Bay to Des Moines via Chicago O'Hare International Airport
- Ave. Duration
- 4h 31m
- When
- Every day
- Estimated price
- $55–350
Flights from General Mitchell International Airport to Des Moines via Chicago O'Hare International Airport
- Ave. Duration
- 4h 41m
- When
- Every day
- Estimated price
- $70–450
Flights from General Mitchell International Airport to Des Moines via Denver
- Ave. Duration
- 6h 2m
- When
- Every day
- Estimated price
- $160–750
Flights from Chicago O'Hare International Airport to Des Moines
- Ave. Duration
- 1h 30m
- When
- Every day
- Estimated price
- $40–270
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Milwaukee to Chicago Union Station
- Ave. Duration
- 1h 29m
- Frequency
- Every 4 hours
- Estimated price
- $21–55
- Website
- Amtrak
Train from Milwaukee to Chicago Union Station
- Ave. Duration
- 1h 29m
- Frequency
- Every 4 hours
- Estimated price
- $21–55
- Website
- Amtrak
Train from Chicago Union Station to Galesburg Amtrak Station
- Ave. Duration
- 2h 36m
- Frequency
- 4 times a day
- Estimated price
- $40–110
- Website
- Amtrak
Train from Milwaukee to St. Paul-Minneapolis
- Ave. Duration
- 5h 52m
- Frequency
- 3 times a day
- Estimated price
- $80–210
- Website
- Amtrak
- Phone
- +1 989-725-5105
- Website
- Indian Trails
Bus from Manitowoc, WI to Milwaukee
- Ave. Duration
- 1h 45m
- Frequency
- Twice daily
- Estimated price
- $14–35
- Website
- Indian Trails
Bus from Manitowoc, WI to Green Bay, WI - Transit
- Ave. Duration
- 40 min
- Frequency
- Twice daily
- Estimated price
- $8–21
- Website
- Indian Trails
Bus from Manitowoc, WI to Milwaukee
- Ave. Duration
- 1h 45m
- Frequency
- Twice daily
- Estimated price
- $14–35
- Website
- Indian Trails
Bus from Manitowoc, WI to Milwaukee
- Ave. Duration
- 1h 45m
- Frequency
- Twice daily
- Estimated price
- $14–35
- Website
- Indian Trails
Bus from Manitowoc, WI to Milwaukee
- Ave. Duration
- 1h 45m
- Frequency
- Twice daily
- Estimated price
- $14–35
- Website
- Indian Trails
Bus from Manitowoc, WI to Milwaukee
- Ave. Duration
- 1h 45m
- Frequency
- Twice daily
- Estimated price
- $14–35
- Website
- Indian Trails
Bus from Manitowoc, WI to Milwaukee
- Ave. Duration
- 1h 45m
- Frequency
- Twice daily
- Estimated price
- $14–35
- Website
- Indian Trails
- Ave. Duration
- 1h 15m
- Estimated price
- $110–140
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Booking & Getting There
There are 254+ hotels available in Des Moines.





