There are 7 ways to get from Manitowoc to La Crosse by bus, train, bus (Greyhound), car, taxi, or plane
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus, train
best- Take the bus from Manitowoc, WI to Milwaukeebus 1490 / ...
- Take the train from Milwaukee to La Crosse Amtrak Stationtrain Empire Builder / ...
6h 7m$69–149Drive 209.1 mi
cheapest- Drive from Manitowoc to La Crossecar 209.1 mi
4h 32m$39–56Bus via Milwaukee
- Take the bus from Manitowoc, WI to Milwaukeebus 1490 / ...
- Take the bus from Milwaukee to La Crossebus Jefferson Lines 966
6h 28m$69–104Taxi to Appleton International Airport, fly
- Take the taxi from Manitowoc to Appleton International Airport (ATW)taxi
- Fly from Appleton International Airport (ATW) to La Crosse (LSE)plane ATW - LSE
5h 56m$181–485Bus
- Take the bus from Manitowoc, WI to Green Bay, WI - Transitbus 1490 / ...
- Take the bus from Green Bay station to La Crosse Grand River Stationbus Green Bay
6h 58m$51–63Bus to Green Bay, fly
- Take the bus from Manitowoc, WI to Green Bay, WI - Transitbus
- Fly from Green Bay (GRB) to La Crosse (LSE)plane GRB - LSE
5h 55m$116–427Bus, bus to Chicago O'Hare International Airport, fly
- Take the bus from Manitowoc, WI to Milwaukeebus
- Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departuresbus
- Fly from Chicago O'Hare International Airport (ORD) to La Crosse (LSE)plane ORD - LSE
6h 59m$111–364
Appleton International Airport (ATW) to La Crosse (LSE) flights
Comparing Your Travel Options
The cheapest way to get from Manitowoc to La Crosse is to drive which costs $35 - $55 and takes 4h 32m.
The fastest way to get from Manitowoc to La Crosse is to drive which takes 4h 32m and costs $35 - $55.
No, there is no direct bus from Manitowoc to La Crosse. However, there are services departing from Manitowoc, WI and arriving at La Crosse via Milwaukee. The journey, including transfers, takes approximately 6h 28m.
The distance between Manitowoc and La Crosse is 280 miles. The road distance is 210.3 miles.
The best way to get from Manitowoc to La Crosse without a car is to bus and train which takes 6h 7m and costs $65 - $150.
It takes approximately 6h 7m to get from Manitowoc to La Crosse, including transfers.
Manitowoc to La Crosse bus services, operated by Indian Trails, depart from Manitowoc, WI station.
Manitowoc to La Crosse bus services, operated by Indian Trails, arrive at Milwaukee station.
Yes, the driving distance between Manitowoc to La Crosse is 210 miles. It takes approximately 4h 32m to drive from Manitowoc to La Crosse.
Book your Manitowoc to La Crosse bus tickets online with Omio.
What companies run services between Manitowoc, WI, USA and La Crosse, WI, USA?
You can take a vehicle from Manitowoc to La Crosse via Manitowoc, WI and Milwaukee in around 6h 28m.
- Website
- aa.com
Flights from Appleton International Airport to La Crosse via Chicago O'Hare International Airport
- Ave. Duration
- 5h 38m
- When
- Every day
- Estimated price
- $50–330
Flights from Green Bay to La Crosse via Chicago O'Hare International Airport
- Ave. Duration
- 5h 17m
- When
- Every day
- Estimated price
- $50–340
Flights from Chicago O'Hare International Airport to La Crosse
- Ave. Duration
- 1h 22m
- When
- Every day
- Estimated price
- $35–270
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Milwaukee to La Crosse Amtrak Station
- Ave. Duration
- 3h 19m
- Frequency
- 3 times a day
- Estimated price
- $50–120
- Website
- Amtrak
- Phone
- +1 989-725-5105
- Website
- Indian Trails
Bus from Manitowoc, WI to Milwaukee
- Ave. Duration
- 1h 45m
- Frequency
- Twice daily
- Estimated price
- $14–35
- Website
- Indian Trails
Bus from Manitowoc, WI to Milwaukee
- Ave. Duration
- 1h 45m
- Frequency
- Twice daily
- Estimated price
- $14–35
- Website
- Indian Trails
Bus from Manitowoc, WI to Green Bay, WI - Transit
- Ave. Duration
- 40 min
- Frequency
- Twice daily
- Estimated price
- $8–21
- Website
- Indian Trails
Bus from Manitowoc, WI to Green Bay, WI - Transit
- Ave. Duration
- 40 min
- Frequency
- Twice daily
- Estimated price
- $8–21
- Website
- Indian Trails
Bus from Manitowoc, WI to Milwaukee
- Ave. Duration
- 1h 45m
- Frequency
- Twice daily
- Estimated price
- $14–35
- Website
- Indian Trails
- Ave. Duration
- 1h 15m
- Estimated price
- $110–140
Want to know more about travelling around United States
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Booking & Getting There
There are 47+ hotels available in La Crosse.





