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How to get fromManitowoc to Mayo Clinicby bus (Greyhound), car, bus, plane, or taxi

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There are 8 ways to get from Manitowoc to Mayo Clinic by bus (Greyhound), car, bus, plane, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus via Milwaukee

    best
    1. Take the bus from Manitowoc, WI to Milwaukeebus bus 1490 / ...
    2. Take the bus from Milwaukee to Rochesterbus bus Jefferson Lines 966
    8h 37m
    $89–129

  2. Drive  274.2 mi

    cheapest
    1. Drive from Manitowoc to Mayo Cliniccar car 274.2 mi
    5h 35m
    $50–73

  3. Bus to Green Bay, fly to Rochester

    1. Take the bus from Manitowoc, WI to Green Bay, WI - Transitbus bus
    2. Fly from Green Bay (GRB) to Rochester (RST)plane plane GRB - RST
    7h 4m
    $98–424

  4. Bus

    1. Take the bus from Manitowoc, WI to Green Bay, WI - Transitbus bus
    2. Take the bus from Green Bay station to La Crosse Grand River Stationbus bus
    3. Take the bus from La Crosse to Rochesterbus bus
    9h 57m
    $79–103

  5. Taxi to Appleton International Airport, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the taxi from Manitowoc to Appleton International Airport (ATW)taxi taxi
    2. Fly from Appleton International Airport (ATW) to Minneapolis–Saint Paul International Airport (MSP)plane plane ATW - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    5h 27m
    $214–554

  6. Bus to Green Bay, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the bus from Manitowoc, WI to Green Bay, WI - Transitbus bus
    2. Fly from Green Bay (GRB) to Minneapolis–Saint Paul International Airport (MSP)plane plane GRB - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    6h 9m
    $154–496

  7. Bus to General Mitchell International Airport, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the bus from Manitowoc, WI to Milwaukeebus bus
    2. Fly from General Mitchell International Airport (MKE) to Minneapolis–Saint Paul International Airport (MSP)plane plane MKE - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 35m
    $673–1,095

  8. Bus, bus to Chicago O'Hare International Airport, fly to Rochester

    1. Take the bus from Manitowoc, WI to Milwaukeebus bus
    2. Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departuresbus bus
    3. Fly from Chicago O'Hare International Airport (ORD) to Rochester (RST)plane plane ORD - RST
    8h 9m
    $98–381

Green Bay (GRB) to Rochester (RST) flights

Calendar49Weekly Planes
Duration4h 41mAverage Duration
Ticket$50Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Manitowoc to Mayo Clinic.ExpandLaunch map view
  • Distance: 361.2 mi
  • Duration: 8h 37m

What companies run services between Manitowoc, WI, USA and Mayo Clinic, MN, USA?

You can take a vehicle from Manitowoc to Mayo Clinic via Manitowoc, WI, Milwaukee, and Rochester in around 8h 37m.

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