There are 10 ways to get from Mannheim to Grenoble by train (TGV), bus, car, train, plane, or night train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Train
best- Take the train from Mannheim, Hauptbahnhof to Karlsruhe Hauptbahnhoftrain 12 / ...
- Take the train from Karlsruhe Hauptbahnhof to Strasbourg Bahnhoftrain 83 / ...
- Take the train from Strasbourg to Lyon Part Dieutrain Tgv
- Take the train from Lyon Part Dieu to Grenobletrain Ter
8h 54m€140–245Bus
cheapest- Take the bus from Mannheim central bus station to Lyonbus N7720 / ...
- Take the bus from Lyon to Grenoblebus S1777 / ...
10h 23m€58–97Drive 641.7 km
- Drive from Mannheim to Grenoblecar 641.7 km
6h 11m€122–175Train to Frankfurt, fly to Lyon–Saint Exupéry Airport, train
- Take the train from Mannheim, Hauptbahnhof to Frankfurttrain
- Fly from Frankfurt (FRA) to Lyon–Saint Exupéry Airport (LYS)plane FRA - LYS
- Take the train from Lyon-Saint Exupery Tgv to Grenobletrain
5h 41m€140–377Train, bus
- Take the train from Mannheim, Hauptbahnhof to Basel SBBtrain 12 / ...
- Take the train from Basel SBB to Renens VDtrain
- Take the train from Renens VD to Lancy-Pont-Rougetrain
- Take the bus from Lancy Pont Rouge Gare-Etoile P+R to Gare Routierebus 272
- Take the train from Annecy to Grenobletrain Ter
10h 19m€144–248Night train, bus, train
- Take the nighttrain from Mannheim Hbf to Basel Sbbnighttrain Nj
- Take the bus from Basel SBB to Annecybus
- Take the train from Annecy to Grenobletrain K21
11h 1m€79–177Train to Frankfurt, fly to Geneva International Airport, bus, train
- Take the train from Mannheim, Hauptbahnhof to Frankfurttrain
- Fly from Frankfurt (FRA) to Geneva International Airport (GVA)plane FRA - GVA
- Take the bus from Geneva - Airport Bus Station to Chambéry - Bus Stationbus
- Take the train from Chambery Challes Les Eaux to Grenobletrain
6h 42m€138–328Train, train to Strasbourg International Airport, fly to Lyon–Saint Exupéry Airport
- Take the train from Mannheim, Hauptbahnhof to Karlsruhe Hauptbahnhoftrain
- Take the train from Karlsruhe Hauptbahnhof to Strasbourg Bahnhoftrain
- Fly from Strasbourg International Airport (SXB) to Lyon–Saint Exupéry Airport (LYS)plane SXB - LYS
- Take the train from Lyon-Saint Exupery Tgv to Grenobletrain
6h 22m€143–393Train to Frankfurt, fly to Turin Caselle Airport, train
- Take the train from Mannheim, Hauptbahnhof to Frankfurttrain
- Fly from Frankfurt (FRA) to Turin Caselle Airport (TRN)plane FRA - TRN
- Take the train from Torino Porta Susa to Chambery Challes Les Eauxtrain
- Take the train from Chambery Challes Les Eaux to Grenobletrain
9h 6m€141–388Train, bus to Luxembourg, fly to Geneva International Airport, bus
- Take the train from Mannheim, Hauptbahnhof to Saarbrücken Hbftrain
- Take the bus from Saarbrücken Hbf to Luxembourgbus
- Fly from Luxembourg (LUX) to Geneva International Airport (GVA)plane LUX - GVA
- Take the bus from Geneva - Airport Bus Station to Chambéry - Bus Stationbus
- Take the train from Chambery Challes Les Eaux to Grenobletrain
9h 38m
Mannheim to Grenoble by train
Comparing Your Travel Options
The cheapest way to get from Mannheim to Grenoble is to bus which costs €55 - €100 and takes 10h 23m.
The fastest way to get from Mannheim to Grenoble is to train and fly which takes 5h 41m and costs €140 - €380.
No, there is no direct bus from Mannheim station to Grenoble. However, there are services departing from Mannheim central bus station and arriving at Grenoble via Lyon. The journey, including transfers, takes approximately 10h 23m.
No, there is no direct train from Mannheim to Grenoble. However, there are services departing from Mannheim, Hauptbahnhof and arriving at Grenoble via Karlsruhe Hauptbahnhof, Strasbourg and Lyon Part Dieu. The journey, including transfers, takes approximately 8h 54m.
The distance between Mannheim and Grenoble is 777 km. The road distance is 641.7 km.
The best way to get from Mannheim to Grenoble without a car is to train which takes 8h 54m and costs €140 - €250.
It takes approximately 8h 54m to get from Mannheim to Grenoble, including transfers.
Mannheim to Grenoble bus services, operated by FlixBus, depart from Mannheim central bus station.
Mannheim to Grenoble train services, operated by Deutsche Bahn Intercity (DB IC), depart from Mannheim, Hauptbahnhof station.
The best way to get from Mannheim to Grenoble is to train which takes 8h 54m and costs €140 - €250. Alternatively, you can bus, which costs €55 - €100 and takes 10h 23m.
What companies run services between Mannheim, Germany and Grenoble, France?
You can take a train from Mannheim, Hauptbahnhof to Grenoble via Karlsruhe Hauptbahnhof, Strasbourg Bahnhof, Strasbourg, and Lyon Part Dieu in around 8h 54m. Alternatively, you can take a bus from Mannheim central bus station to Grenoble via Lyon in around 10h 23m.
- Website
- lufthansa.com
Flights from Frankfurt to Lyon–Saint Exupéry Airport
- Ave. Duration
- 1h 20m
- When
- Every day
- Estimated price
- €75–550
Flights from Frankfurt to Lyon–Saint Exupéry Airport via Munich
- Ave. Duration
- 3h 40m
- When
- Monday, Wednesday, Thursday, and Friday
- Estimated price
- €80–250
Flights from Frankfurt to Geneva International Airport
- Ave. Duration
- 1h 12m
- When
- Every day
- Estimated price
- €100–470
Flights from Frankfurt to Geneva International Airport via Munich
- Ave. Duration
- 3h
- When
- Every day
- Estimated price
- €100–230
Flights from Frankfurt to Turin Caselle Airport
- Ave. Duration
- 1h 25m
- When
- Every day
- Estimated price
- €150–490
Flights from Frankfurt to Turin Caselle Airport via Munich
- Ave. Duration
- 3h 20m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- €110–500
- Website
- swiss.com
Flights from Frankfurt to Geneva International Airport
- Ave. Duration
- 1h 12m
- When
- Every day
- Estimated price
- €100–470
Flights from Frankfurt to Geneva International Airport via Zurich
- Ave. Duration
- 2h 53m
- When
- Every day
- Estimated price
- €100–470
Flights from Luxembourg to Geneva International Airport via Zurich
- Ave. Duration
- 2h 51m
- When
- Every day
- Estimated price
- €90–320
- Website
- airbus.com
Flights from Frankfurt to Lyon–Saint Exupéry Airport
- Ave. Duration
- 1h 20m
- When
- Every day
- Estimated price
- €75–240
- Website
- airdolomiti.it
Flights from Frankfurt to Lyon–Saint Exupéry Airport
- Ave. Duration
- 1h 20m
- When
- Monday to Saturday
- Estimated price
- €170–550
Flights from Frankfurt to Geneva International Airport
- Ave. Duration
- 1h 15m
- When
- Every day
- Estimated price
- €150–470
Flights from Frankfurt to Turin Caselle Airport
- Ave. Duration
- 1h 25m
- When
- Every day
- Estimated price
- €150–490
- Website
- luxair.lu
Flights from Luxembourg to Geneva International Airport
- Ave. Duration
- 1h 5m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- €75–240
- Website
- brusselsairlines.com
Flights from Frankfurt to Lyon–Saint Exupéry Airport via Brussels
- Ave. Duration
- 3h 20m
- When
- Tuesday, Thursday, Friday, and Sunday
- Estimated price
- €75–280
Flights from Frankfurt to Geneva International Airport via Brussels
- Ave. Duration
- 3h 20m
- When
- Every day
- Estimated price
- €150–300
- Website
- twinjet.fr
Flights from Strasbourg International Airport to Lyon–Saint Exupéry Airport
- Ave. Duration
- 1h 10m
- When
- Monday to Wednesday
- Estimated price
- €420–1,100
- Website
- airfrance.com
Flights from Frankfurt to Lyon–Saint Exupéry Airport via Paris Charles de Gaulle
- Ave. Duration
- 3h 35m
- When
- Every day
- Estimated price
- €55–340
- Phone
- +49 30 2970
- Website
- Deutsche Bahn Intercity (DB IC)
Train from Mannheim, Hauptbahnhof to Karlsruhe Hauptbahnhof
- Ave. Duration
- 22 min
- Frequency
- Hourly
- Estimated price
- €9–19
- Website
- Deutsche Bahn Intercity (DB IC)
Train from Karlsruhe Hauptbahnhof to Strasbourg Bahnhof
- Ave. Duration
- 43 min
- Frequency
- Every 3 hours
- Estimated price
- €13–26
- Website
- Deutsche Bahn Intercity (DB IC)
Train from Mannheim, Hauptbahnhof to Frankfurt
- Ave. Duration
- 31 min
- Frequency
- Hourly
- Estimated price
- €11–23
- Website
- Deutsche Bahn Intercity (DB IC)
Train from Mannheim, Hauptbahnhof to Basel SBB
- Ave. Duration
- 2h 12m
- Frequency
- Hourly
- Estimated price
- €40–80
- Website
- Deutsche Bahn Intercity (DB IC)
Train from Mannheim, Hauptbahnhof to Frankfurt
- Ave. Duration
- 31 min
- Frequency
- Hourly
- Estimated price
- €11–23
- Website
- Deutsche Bahn Intercity (DB IC)
Train from Mannheim, Hauptbahnhof to Karlsruhe Hauptbahnhof
- Ave. Duration
- 22 min
- Frequency
- Hourly
- Estimated price
- €9–19
- Website
- Deutsche Bahn Intercity (DB IC)
Train from Karlsruhe Hauptbahnhof to Strasbourg Bahnhof
- Ave. Duration
- 43 min
- Frequency
- Every 3 hours
- Estimated price
- €13–26
- Website
- Deutsche Bahn Intercity (DB IC)
Train from Mannheim, Hauptbahnhof to Frankfurt
- Ave. Duration
- 31 min
- Frequency
- Hourly
- Estimated price
- €11–23
- Website
- Deutsche Bahn Intercity (DB IC)
Train from Mannheim, Hauptbahnhof to Saarbrücken Hbf
- Ave. Duration
- 1h 19m
- Frequency
- Every 4 hours
- Estimated price
- €21–40
- Website
- Deutsche Bahn Intercity (DB IC)
- Phone
- +49 30 2970
- Website
- Deutsche Bahn Regio (DB Regional)
Train from Mannheim, Hauptbahnhof to Karlsruhe Hauptbahnhof
- Ave. Duration
- 57 min
- Frequency
- Every 30 minutes
- Estimated price
- €6–10
- Website
- Deutsche Bahn Regio (DB Regional)
Train from Mannheim, Hauptbahnhof to Karlsruhe Hauptbahnhof
- Ave. Duration
- 57 min
- Frequency
- Every 30 minutes
- Estimated price
- €6–10
- Website
- Deutsche Bahn Regio (DB Regional)
- Phone
- +43 (0) 5 1717
- Website
- ÖBB EuroCity
Train from Mannheim, Hauptbahnhof to Karlsruhe Hauptbahnhof
- Ave. Duration
- 42 min
- Frequency
- Twice daily
- Estimated price
- €16
- Website
- ÖBB EuroCity
- Website
- ÖBB EuroCity
Train from Mannheim, Hauptbahnhof to Karlsruhe Hauptbahnhof
- Ave. Duration
- 42 min
- Frequency
- Twice daily
- Estimated price
- €16
- Website
- ÖBB EuroCity
- Website
- ÖBB EuroCity
- Phone
- +49 621 830 1200
- Website
- Süwex
Train from Mannheim, Hauptbahnhof to Karlsruhe Hauptbahnhof
- Ave. Duration
- 1h 6m
- Frequency
- 5 times a week
- Estimated price
- €13–19
- Schedules at
- Süwex
Train from Mannheim, Hauptbahnhof to Karlsruhe Hauptbahnhof
- Ave. Duration
- 1h 6m
- Frequency
- 5 times a week
- Estimated price
- €13–19
- Schedules at
- Süwex
Train from Mannheim, Hauptbahnhof to Saarbrücken Hbf
- Ave. Duration
- 1h 36m
- Frequency
- Every 2 hours
- Estimated price
- €22–30
- Schedules at
- Süwex
- Phone
- +49 6131 4975 022
- [email protected]
- Website
- dbregiobus-mitte.de
Train from Mannheim, Hauptbahnhof to Karlsruhe Hauptbahnhof
- Ave. Duration
- 1h 46m
- Frequency
- Once a week
- Estimated price
- €13–19
- Schedules at
- dbregiobus-mitte.de
Train from Mannheim, Hauptbahnhof to Karlsruhe Hauptbahnhof
- Ave. Duration
- 1h 46m
- Frequency
- Once a week
- Estimated price
- €13–19
- Schedules at
- dbregiobus-mitte.de
- Phone
- +33 1 84 94 36 35
- Website
- TGV inOui
Train from Strasbourg to Lyon Part Dieu
- Ave. Duration
- 4h 12m
- Frequency
- Every 4 hours
- Estimated price
- €100–160
- Website
- TGV inOui
Train from Lyon Part Dieu to Grenoble
- Ave. Duration
- 1h 11m
- Frequency
- 4 times a week
- Estimated price
- €26–40
- Website
- TGV inOui
Train from Lyon-Saint Exupery Tgv to Grenoble
- Ave. Duration
- 1h 4m
- Frequency
- Hourly
- Estimated price
- €23–35
- Website
- TGV inOui
Train from Lyon-Saint Exupery Tgv to Grenoble
- Ave. Duration
- 1h 4m
- Frequency
- Hourly
- Estimated price
- €23–35
- Website
- TGV inOui
Train from Torino Porta Susa to Chambery Challes Les Eaux
- Ave. Duration
- 2h 34m
- Frequency
- Every 4 hours
- Estimated price
- €35–60
- Website
- TGV inOui
Rome2Rio's guide to Société Nationale des Chemins de fer Français (SNCF)
Contact Details
- Phone
- +33 1 84 94 36 35
- Website
- Oui.SNCF
Train from Strasbourg to Lyon Part Dieu
- Ave. Duration
- 4h 20m
- Frequency
- Twice daily
- Estimated price
- €95–150
- Website
- Oui.SNCF
Train from Lyon Part Dieu to Grenoble
- Ave. Duration
- 1h 23m
- Frequency
- Every 30 minutes
- Estimated price
- €25–40
- Website
- Oui.SNCF
Train from Lyon-Saint Exupery Tgv to Grenoble
- Ave. Duration
- 1h 12m
- Frequency
- Twice daily
- Estimated price
- €22–35
- Website
- Oui.SNCF
Train from Annecy to Grenoble
- Ave. Duration
- 1h 45m
- Frequency
- Hourly
- Estimated price
- €23–40
- Website
- Oui.SNCF
Train from Chambery Challes Les Eaux to Grenoble
- Ave. Duration
- 48 min
- Frequency
- Every 30 minutes
- Estimated price
- €13–21
- Website
- Oui.SNCF
Train from Lyon-Saint Exupery Tgv to Grenoble
- Ave. Duration
- 1h 12m
- Frequency
- Twice daily
- Estimated price
- €22–35
- Website
- Oui.SNCF
Train from Chambery Challes Les Eaux to Grenoble
- Ave. Duration
- 48 min
- Frequency
- Every 30 minutes
- Estimated price
- €13–21
- Website
- Oui.SNCF
Train from Chambery Challes Les Eaux to Grenoble
- Ave. Duration
- 48 min
- Frequency
- Every 30 minutes
- Estimated price
- €13–21
- Website
- Oui.SNCF
- Phone
- +31 30 751 5155
- Website
- Nederlandse Spoorwegen (NS)
Train from Mannheim, Hauptbahnhof to Frankfurt
- Ave. Duration
- 31 min
- Frequency
- Once daily
- Estimated price
- €8–15
- Website
- Nederlandse Spoorwegen (NS)
Night train from Mannheim Hbf to Basel Sbb
- Ave. Duration
- 2h 50m
- Frequency
- Twice daily
- Estimated price
- €28–55
- Website
- Nederlandse Spoorwegen (NS)
Train from Mannheim, Hauptbahnhof to Frankfurt
- Ave. Duration
- 31 min
- Frequency
- Once daily
- Estimated price
- €8–15
- Website
- Nederlandse Spoorwegen (NS)
Train from Mannheim, Hauptbahnhof to Frankfurt
- Ave. Duration
- 31 min
- Frequency
- Once daily
- Estimated price
- €8–15
- Website
- Nederlandse Spoorwegen (NS)
Train from Basel SBB to Renens VD
- Ave. Duration
- 2h 16m
- Frequency
- Hourly
- Estimated price
- €55–90
- Website
- Swiss Federal Railways (SBB CFF FFS)
Train from Renens VD to Lancy-Pont-Rouge
- Ave. Duration
- 53 min
- Frequency
- Hourly
- Estimated price
- €19–30
- Website
- Swiss Federal Railways (SBB CFF FFS)
- Phone
- +43 (0) 51717
- Website
- Nightjet
Night train from Mannheim Hbf to Basel Sbb
- Ave. Duration
- 2h 47m
- Frequency
- 3 times a day
- Estimated price
- €23–95
- Website
- Nightjet
- Sleeper Carriage
- €85–95
- Couchette Carriage
- €55–65
- Seating Carriage
- €23–28
- Phone
- +33 4 13 94 30 50
- Website
- Zou! Lignes Express Régionales
Train from Annecy to Grenoble
- Ave. Duration
- 1h 44m
- Frequency
- Every 2 hours
- Estimated price
- €30–45
- Website
- Zou! Lignes Express Régionales
Train from Chambery Challes Les Eaux to Grenoble
- Ave. Duration
- 48 min
- Frequency
- Hourly
- Estimated price
- €17–23
- Website
- Zou! Lignes Express Régionales
Train from Chambery Challes Les Eaux to Grenoble
- Ave. Duration
- 48 min
- Frequency
- Hourly
- Estimated price
- €17–23
- Website
- Zou! Lignes Express Régionales
Train from Chambery Challes Les Eaux to Grenoble
- Ave. Duration
- 48 min
- Frequency
- Hourly
- Estimated price
- €17–23
- Website
- Zou! Lignes Express Régionales
- Phone
- +39.06.5210550
- Website
- Trenitalia
Train from Torino Porta Susa to Chambery Challes Les Eaux
- Ave. Duration
- 2h 35m
- Frequency
- 4 times a day
- Estimated price
- €23–35
- Website
- Trenitalia
- Phone
- +49 30 300 137 300
- [email protected]
- Website
- Flixbus
Bus from Mannheim central bus station to Lyon
- Ave. Duration
- 8h 50m
- Frequency
- Twice daily
- Estimated price
- €55–85
- Website
- Flixbus
Bus from Lyon to Grenoble
- Ave. Duration
- 1h 20m
- Frequency
- Hourly
- Estimated price
- €9–14
- Website
- Flixbus
Bus from Basel SBB to Annecy
- Ave. Duration
- 4h 30m
- Frequency
- Once daily
- Estimated price
- €26–40
- Website
- Flixbus
Bus from Geneva - Airport Bus Station to Chambéry - Bus Station
- Ave. Duration
- 1h 30m
- Frequency
- Every 4 hours
- Estimated price
- €8–13
- Website
- Flixbus
Bus from Geneva - Airport Bus Station to Chambéry - Bus Station
- Ave. Duration
- 1h 30m
- Frequency
- Every 4 hours
- Estimated price
- €8–13
- Website
- Flixbus
- Phone
- +3 318 576 2228
- Website
- BlaBlaCar Bus
Bus from Mannheim central bus station to Lyon
- Ave. Duration
- 9h 5m
- Frequency
- Twice daily
- Estimated price
- €50–85
- Website
- BlaBlaCar Bus
Bus from Lyon to Grenoble
- Ave. Duration
- 1h 45m
- Frequency
- Every 30 minutes
- Estimated price
- €8–14
- Website
- BlaBlaCar Bus
Bus from Geneva - Airport Bus Station to Chambéry - Bus Station
- Ave. Duration
- 1h 30m
- Frequency
- Hourly
- Estimated price
- €7–13
- Website
- BlaBlaCar Bus
Bus from Geneva - Airport Bus Station to Chambéry - Bus Station
- Ave. Duration
- 1h 30m
- Frequency
- Hourly
- Estimated price
- €7–13
- Website
- BlaBlaCar Bus
- Phone
- +33 4 8000 7000
- Website
- auvergnerhonealpes.fr
Bus from Lancy Pont Rouge Gare-Etoile P+R to Gare Routiere
- Ave. Duration
- 1h 23m
- Frequency
- Every 30 minutes
- Estimated price
- €6–9
- Schedules at
- laregionvoustransporte.fr
- Phone
- +352 24 89 24 89
- Website
- Luxembourg Railways (CFL)
Bus from Saarbrücken Hbf to Luxembourg
- Ave. Duration
- 1h 15m
- Frequency
- Hourly
- Website
- Luxembourg Railways (CFL)
Want to know more about travelling around France
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Booking & Getting There
Mannheim to Grenoble bus services, operated by FlixBus, arrive at Lyon station.
Mannheim to Grenoble train services, operated by Deutsche Bahn Intercity (DB IC), arrive at Karlsruhe Hauptbahnhof station.
Yes, the driving distance between Mannheim to Grenoble is 642 km. It takes approximately 6h 11m to drive from Mannheim to Grenoble.
Book your Mannheim to Grenoble train tickets online with Omio.
Book your Mannheim to Grenoble bus tickets online with Omio, FlixBus and 12go.asia.
There are 2321+ hotels available in Grenoble.




























































