There are 6 ways to get from Mannheim to Lyon by train (TGV), bus, car, train, plane, or night train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Train
best- Take the train from Mannheim, Hauptbahnhof to Strasbourg Bahnhoftrain 82 / ...
- Take the train from Strasbourg to Lyon Part Dieutrain Tgv
6h 21m€109–203Bus
cheapest- Take the bus from Mannheim - Bus Station to Lyon - Gerland Bus Stationbus BlaBlaCar Bus
9h 5m€45–85Drive 597.8 km
- Drive from Mannheim to Lyoncar 597.8 km
5h 59m€96–139Train to Frankfurt, fly
- Take the train from Mannheim, Hauptbahnhof to Frankfurttrain
- Fly from Frankfurt (FRA) to Lyon–Saint Exupéry Airport (LYS)plane FRA - LYS
4h 37m€134–353Night train, train, bus
- Take the nighttrain from Mannheim Hbf to Basel Sbbnighttrain Nj
- Take the train from Basel SBB to Lausannetrain
- Take the bus from Lausanne Bus Station to Lyon Perrache Bus Stationbus
10h 22m€105–228Train to Strasbourg International Airport, fly
- Take the train from Mannheim, Hauptbahnhof to Strasbourg Bahnhoftrain
- Fly from Strasbourg International Airport (SXB) to Lyon–Saint Exupéry Airport (LYS)plane SXB - LYS
4h 22m€141–392
Mannheim to Lyon by train
Comparing Your Travel Options
The cheapest way to get from Mannheim to Lyon is to bus which costs €45 - €85 and takes 9h 5m.
The fastest way to get from Mannheim to Lyon is to train and fly which takes 4h 22m and costs €140 - €400.
Yes, there is a direct bus departing from Mannheim - Bus Station station and arriving at Lyon - Gerland Bus Station station. Services depart three times a day, and operate every day. The journey takes approximately 9h 5m.
No, there is no direct train from Mannheim to Lyon. However, there are services departing from Mannheim, Hauptbahnhof and arriving at Lyon Part Dieu via Strasbourg. The journey, including transfers, takes approximately 6h 21m.
The distance between Mannheim and Lyon is 646 km. The road distance is 597.8 km.
The best way to get from Mannheim to Lyon without a car is to train which takes 6h 21m and costs €100 - €210.
It takes approximately 6h 21m to get from Mannheim to Lyon, including transfers.
Mannheim to Lyon bus services, operated by BlaBlaCar Bus, depart from Mannheim - Bus Station.
Mannheim to Lyon train services, operated by Deutsche Bahn Intercity (DB IC), depart from Mannheim, Hauptbahnhof station.
The best way to get from Mannheim to Lyon is to train which takes 6h 21m and costs €100 - €210. Alternatively, you can bus, which costs €45 - €85 and takes 9h 5m.
What companies run services between Mannheim, Germany and Lyon, France?
You can take a train from Mannheim, Hauptbahnhof to Lyon Part Dieu via Strasbourg Bahnhof and Strasbourg in around 6h 21m. Alternatively, BlaBlaCar Bus operates a bus from Mannheim - Bus Station to Lyon - Gerland Bus Station once daily. Tickets cost €45–80 and the journey takes 9h 5m. FlixBus also services this route twice daily.
- Website
- lufthansa.com
Flights from Frankfurt to Lyon–Saint Exupéry Airport
- Ave. Duration
- 1h 20m
- When
- Every day
- Estimated price
- €75–500
- Website
- airbus.com
Flights from Frankfurt to Lyon–Saint Exupéry Airport
- Ave. Duration
- 1h 20m
- When
- Every day
- Estimated price
- €75–250
- Website
- twinjet.fr
Flights from Strasbourg International Airport to Lyon–Saint Exupéry Airport
- Ave. Duration
- 1h 10m
- When
- Monday to Friday
- Estimated price
- €650–1,400
- Website
- airdolomiti.it
Flights from Frankfurt to Lyon–Saint Exupéry Airport
- Ave. Duration
- 1h 20m
- When
- Saturday and Sunday
- Estimated price
- €160–500
- Website
- brusselsairlines.com
Flights from Frankfurt to Lyon–Saint Exupéry Airport via Brussels
- Ave. Duration
- 3h 20m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- €75–280
- Website
- airfrance.com
Flights from Frankfurt to Lyon–Saint Exupéry Airport via Paris Charles de Gaulle
- Ave. Duration
- 3h 35m
- When
- Every day
- Estimated price
- €55–340
- Phone
- +49 30 2970
- Website
- Deutsche Bahn Intercity (DB IC)
Train from Mannheim, Hauptbahnhof to Strasbourg Bahnhof
- Ave. Duration
- 1h 9m
- Frequency
- 4 times a day
- Estimated price
- €24–55
- Website
- Deutsche Bahn Intercity (DB IC)
Train from Mannheim, Hauptbahnhof to Frankfurt
- Ave. Duration
- 31 min
- Frequency
- Hourly
- Estimated price
- €12–27
- Website
- Deutsche Bahn Intercity (DB IC)
Train from Mannheim, Hauptbahnhof to Strasbourg Bahnhof
- Ave. Duration
- 1h 9m
- Frequency
- 4 times a day
- Estimated price
- €24–55
- Website
- Deutsche Bahn Intercity (DB IC)
- Phone
- +33 1 84 94 36 35
- Website
- TGV inOui
Train from Strasbourg to Lyon Part Dieu
- Ave. Duration
- 4h 12m
- Frequency
- Every 4 hours
- Estimated price
- €100–150
- Website
- TGV inOui
Rome2Rio's guide to Société Nationale des Chemins de fer Français (SNCF)
Contact DetailsContact Details
- Phone
- +33 1 84 94 36 35
- Website
- Oui.SNCF
Train from Strasbourg to Lyon Part Dieu
- Ave. Duration
- 4h 20m
- Frequency
- Twice daily
- Estimated price
- €85–150
- Website
- Oui.SNCF
- Phone
- +31 30 751 5155
- Website
- Nederlandse Spoorwegen (NS)
Train from Mannheim, Hauptbahnhof to Frankfurt
- Ave. Duration
- 31 min
- Frequency
- Once daily
- Estimated price
- €7–15
- Website
- Nederlandse Spoorwegen (NS)
Night train from Mannheim Hbf to Basel Sbb
- Ave. Duration
- 2h 50m
- Frequency
- Once daily
- Estimated price
- €27–55
- Website
- Nederlandse Spoorwegen (NS)
- Phone
- +43 (0) 51717
- Website
- Nightjet
Night train from Mannheim Hbf to Basel Sbb
- Ave. Duration
- 2h 47m
- Frequency
- Once daily
- Estimated price
- €23–95
- Website
- Nightjet
- Sleeper Carriage
- €85–95
- Couchette Carriage
- €55–65
- Seating Carriage
- €23–28
Train from Basel SBB to Lausanne
- Ave. Duration
- 2h 24m
- Frequency
- Hourly
- Estimated price
- €65–110
- Website
- Swiss Federal Railways (SBB CFF FFS)
- Phone
- +3 318 576 2228
- Website
- BlaBlaCar Bus
Bus from Mannheim - Bus Station to Lyon - Gerland Bus Station
- Ave. Duration
- 9h 5m
- Frequency
- Once daily
- Estimated price
- €45–80
- Website
- BlaBlaCar Bus
Rome2Rio's guide to FlixBus
Contact DetailsContact Details
- Phone
- +49 30 300 137 300
- [email protected]
- Website
- Flixbus
Bus from Mannheim - Bus Station to Lyon - Gerland Bus Station
- Ave. Duration
- 11h 30m
- Frequency
- Twice daily
- Estimated price
- €55–85
- Website
- Flixbus
- Phone
- +420 222 222 221
- [email protected]
- Website
- RegioJet
Bus from Lausanne Bus Station to Lyon Perrache Bus Station
- Ave. Duration
- 3h 15m
- Frequency
- Twice a week
- Estimated price
- €13–22
- Website
- RegioJet
Want to know more about travelling around France
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Booking & Getting There
Mannheim to Lyon bus services, operated by BlaBlaCar Bus, arrive at Lyon - Gerland Bus Station.
Mannheim to Lyon train services, operated by Deutsche Bahn Intercity (DB IC), arrive at Strasbourg Bahnhof station.
Yes, the driving distance between Mannheim to Lyon is 598 km. It takes approximately 5h 59m to drive from Mannheim to Lyon.
Book your Mannheim to Lyon train tickets online with Omio.
Book your Mannheim to Lyon bus tickets online with Omio and FlixBus.
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