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How to get fromMannheim to Sienaby train, plane, train (Trenitalia), bus, night train, or car

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There are 9 ways to get from Mannheim to Siena by train, plane, train (Trenitalia), bus, night train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Frankfurt, fly to Florence Peretola Airport, train

    best
    1. Take the train from Mannheim, Hauptbahnhof to Frankfurttrain train
    2. Fly from Frankfurt (FRA) to Florence Peretola Airport (FLR)plane plane FRA - FLR
    3. Take the train from Firenze S.M.N. to Sienatrain train
    6h 49m
    €141–345

  2. Train, night train, bus

    cheapest
    1. Take the train from Mannheim, Hauptbahnhof to Hauptbahnhoftrain train 47 / ...
    2. Take the nighttrain from Stuttgart Hbf to Venezia Mestrenighttrain night train Nj
    3. Take the train from Venezia Mestre to Firenze S.M.N.train train Fr
    4. Take the bus from Firenze Autostazione to Siena-Via Tozzibus bus 131
    17h 56m
    €91–236

  3. Train

    1. Take the train from Mannheim, Hauptbahnhof to Basel SBBtrain train 12 / ...
    2. Take the train from Basel SBB to Luganotrain train Ec
    3. Take the train from Lugano to Milano Centraletrain train
    4. Take the train from Milano Centrale to Firenze S.M.N.train train Fr
    5. Take the train from Firenze S.M.N. to Sienatrain train Re
    13h 2m
    €117–382

  4. Bus

    1. Take the bus from Mannheim, Zob to Florence Villa Constanza Bus Stationbus bus
    2. Take the bus from Florence Villa Constanza Bus Station to Sienabus bus 1518 / ...
    15h 47m
    €137–188

  5. Train to Frankfurt, fly to Bologna Guglielmo Marconi Airport, train

    1. Take the train from Mannheim, Hauptbahnhof to Frankfurttrain train
    2. Fly from Frankfurt (FRA) to Bologna Guglielmo Marconi Airport (BLQ)plane plane FRA - BLQ
    3. Take the train from Bologna Centrale to Firenze S.M.N.train train
    4. Take the train from Firenze S.M.N. to Sienatrain train
    7h 22m
    €123–325

  6. Train, train to Zurich Airport, fly to Florence Peretola Airport

    1. Take the train from Mannheim, Hauptbahnhof to Basel SBBtrain train
    2. Take the train from Basel SBB to Zürich HBtrain train
    3. Fly from Zurich Airport (ZRH) to Florence Peretola Airport (FLR)plane plane ZRH - FLR
    4. Take the train from Firenze S.M.N. to Sienatrain train
    9h 44m
    €169–478

  7. Train to Frankfurt, fly to Pisa International Airport, train

    1. Take the train from Mannheim, Hauptbahnhof to Frankfurttrain train
    2. Fly from Frankfurt (FRA) to Pisa International Airport (PSA)plane plane FRA - PSA
    3. Take the train from Pisa Centrale to Empolitrain train
    4. Take the train from Empoli to Sienatrain train
    6h 42m
    €125–323

  8. Bus via Mannheim central bus station

    1. Take the bus from Mannheim central bus station to Florence Villa Constanza Bus Stationbus bus N77
    2. Take the bus from Florence Villa Constanza Bus Station to Sienabus bus 1518 / ...
    17h 15m
    €91–135

  9. Drive  952.8 km

    1. Drive from Mannheim to Sienacar car 952.8 km
    9h 18m
    €155–223

Mannheim to Siena by train

Calendar76Weekly Trains
Duration13h 2mAverage Duration
Ticket€117Cheapest Price
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Comparing Your Travel Options

Map of how to get from Mannheim to Siena.ExpandLaunch map view
  • Distance: 893 km
  • Duration: 6h 49m

What companies run services between Mannheim, Germany and Siena, Italy?

You can take a train from Mannheim, Hauptbahnhof to Siena via Basel SBB, Lugano, Milano Centrale, and Firenze S.M.N. in around 13h 2m. Alternatively, you can take a bus from Mannheim, Zob to Siena via Florence Villa Constanza Bus Station in around 15h 47m.

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