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How to get fromMannheim to Sienaby train, plane, train (Trenitalia), bus, night train, or car

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There are 10 ways to get from Mannheim to Siena by train, plane, train (Trenitalia), bus, night train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Frankfurt, fly to Florence Peretola Airport, train

    best
    1. Take the train from Mannheim, Hauptbahnhof to Frankfurttrain train
    2. Fly from Frankfurt (FRA) to Florence Peretola Airport (FLR)plane plane FRA - FLR
    3. Take the train from Firenze S.M.N. to Sienatrain train
    6h 29m
    €141–342

  2. Bus via Mannheim central bus station

    cheapest
    1. Take the bus from Mannheim central bus station to Florence Villa Constanza Bus Stationbus bus N77
    2. Take the bus from Florence Villa Constanza Bus Station to Sienabus bus N528 / ...
    17h 15m
    €78–124

  3. Train

    1. Take the train from Mannheim, Hauptbahnhof to Basel SBBtrain train 12 / ...
    2. Take the train from Basel SBB to Luganotrain train Ec
    3. Take the train from Lugano to Milano Centraletrain train
    4. Take the train from Milano Centrale to Firenze S.M.N.train train Fr
    5. Take the train from Firenze S.M.N. to Sienatrain train Re
    12h 15m
    €116–628

  4. Bus

    1. Take the bus from Mannheim, Zob to Florence Villa Constanza Bus Stationbus bus
    2. Take the bus from Florence Villa Constanza Bus Station to Sienabus bus N528 / ...
    15h 51m
    €137–187

  5. Train, night train

    1. Take the train from Mannheim, Hauptbahnhof to Hauptbahnhoftrain train 47 / ...
    2. Take the nighttrain from Stuttgart Hbf to Verona Porta Nuovanighttrain night train Nj
    3. Take the train from Verona Porta Nuova to Firenze S.M.N.train train Fr
    4. Take the train from Firenze S.M.N. to Sienatrain train Re
    18h 32m
    €97–284

  6. Train to Frankfurt, fly to Pisa International Airport, train

    1. Take the train from Mannheim, Hauptbahnhof to Frankfurttrain train
    2. Fly from Frankfurt (FRA) to Pisa International Airport (PSA)plane plane FRA - PSA
    3. Take the train from Pisa Centrale to Empolitrain train
    4. Take the train from Empoli to Sienatrain train
    6h 22m
    €125–321

  7. Train to Frankfurt, fly to Bologna Guglielmo Marconi Airport, train

    1. Take the train from Mannheim, Hauptbahnhof to Frankfurttrain train
    2. Fly from Frankfurt (FRA) to Bologna Guglielmo Marconi Airport (BLQ)plane plane FRA - BLQ
    3. Take the train from Bologna Centrale to Firenze S.M.N.train train
    4. Take the train from Firenze S.M.N. to Sienatrain train
    6h 53m
    €124–337

  8. Train to Frankfurt, fly to Venice Marco Polo Airport, train

    1. Take the train from Mannheim, Hauptbahnhof to Frankfurttrain train
    2. Fly from Frankfurt (FRA) to Venice Marco Polo Airport (VCE)plane plane FRA - VCE
    3. Take the train from Venezia Mestre to Firenze S.M.N.train train
    4. Take the train from Firenze S.M.N. to Sienatrain train
    8h 35m
    €120–342

  9. Train, train to Zurich Airport, fly to Florence Peretola Airport

    1. Take the train from Mannheim, Hauptbahnhof to Basel SBBtrain train
    2. Take the train from Basel SBB to Zürich HBtrain train
    3. Fly from Zurich Airport (ZRH) to Florence Peretola Airport (FLR)plane plane ZRH - FLR
    4. Take the train from Firenze S.M.N. to Sienatrain train
    9h 18m
    €174–561

  10. Drive  952.8 km

    1. Drive from Mannheim to Sienacar car 952.8 km
    9h 18m
    €151–217

Mannheim to Siena by train

Calendar76Weekly Trains
Duration12h 15mAverage Duration
Ticket€116Cheapest Price
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Questions & Answers

Map of how to get from Mannheim to Siena.ExpandLaunch map view
  • Distance: 893 km
  • Duration: 6h 29m

What companies run services between Mannheim, Germany and Siena, Italy?

You can take a train from Mannheim, Hauptbahnhof to Siena via Basel SBB, Lugano, Milano Centrale, and Firenze S.M.N. in around 12h 15m. Alternatively, you can take a bus from Mannheim, Zob to Siena via Florence Villa Constanza Bus Station in around 15h 51m.

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