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How to get fromManzanillo to Panama Cityby plane, bus, or car

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There are 6 ways to get from Manzanillo to Panama City by plane, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Playa De Oro International Airport

    best
    1. Fly from Playa De Oro International Airport (ZLO) to Tocumen International Airport (PTY)plane plane ZLO - PTY
    9h 51m
    $297–1,034

  2. Bus to Miguel Hidalgo Y Costilla Guadalajara International Airport, fly

    cheapest
    1. Take the bus from Manzanillo to Guadalajara Airportbus bus
    2. Fly from Miguel Hidalgo Y Costilla Guadalajara International Airport (GDL) to Tocumen International Airport (PTY)plane plane GDL - PTY
    11h 26m
    $170–558

  3. Bus

    1. Take the bus from Manzanillo to Nueva Central Camionera de Guadalajara Mod 1 1/2bus bus
    2. Take the bus from Guadalajara to Los Angelesbus bus
    3. Take the bus from Los Angeles to San Salvadorbus bus
    4. Take the bus from Terminal Tica Bus San Salvador to Terminal Tica Bus San Josébus bus
    5. Take the bus from Terminal Tica Bus San José to Terminal Tica Bus Panamábus bus
    7d 11h
    $586–775

  4. Drive  3,896.5 km

    1. Drive from Manzanillo to Panama Citycar car 3,896.5 km
    2d 5h
    $533–770

  5. Bus to Licenciado Miguel De La Madrid Airport, fly

    1. Take the bus from Manzanillo to Colimabus bus
    2. Fly from Licenciado Miguel De La Madrid Airport (CLQ) to Tocumen International Airport (PTY)plane plane CLQ - PTY
    19h 42m
    $254–968

  6. Bus to Licenciado Gustavo Díaz Ordaz International Airport, fly

    1. Take the bus from Manzanillo to Puerto Vallartabus bus
    2. Fly from Licenciado Gustavo Díaz Ordaz International Airport (PVR) to Tocumen International Airport (PTY)plane plane PVR - PTY
    14h 6m
    $429–1,569

Playa De Oro International Airport (ZLO) to Tocumen International Airport (PTY) flights

Calendar28Weekly Planes
Duration13h 37mAverage Duration
Ticket$222Cheapest Price
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Comparing Your Travel Options

Map of how to get from Manzanillo to Panama City.ExpandLaunch map view
  • Distance: 2,986.9 km
  • Duration: 9h 51m

What companies run services between Manzanillo, Mexico and Panama City, Panama?

Aeroméxico, Copa Airlines, and two other airlines fly from Playa De Oro International Airport (ZLO) to Tocumen International Airport (PTY) 4 times a day. Alternatively, you can take a bus from Parada en Av. Elias Zamora Verduzco to Terminal Tica Bus Panamá via Parada en Obras Maritimas 42, Manzanillo, Nueva Central Camionera de Guadalajara Mod 1 1/2, Guadalajara, Los Angeles, San Salvador, Terminal Tica Bus San Salvador, and Terminal Tica Bus San José in around 7d 11h.

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