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How to get fromManzanillo to Panama Cityby plane, bus, or car

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There are 6 ways to get from Manzanillo to Panama City by plane, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Playa De Oro International Airport

    best
    1. Fly from Playa De Oro International Airport (ZLO) to Tocumen International Airport (PTY)plane plane ZLO - PTY
    7h 34m
    $220–688

  2. Bus via Mexico City

    1. Take the bus from Manzanillo to Terminal Central de Autobuses del Nortebus bus
    2. Take the bus from Politécnico to Tapachulabus bus
    3. Take the bus from Tapachula to San Salvadorbus bus
    4. Take the bus from Terminal San Carlos - CCA to Terminal Atlántico Nortebus bus Sac
    5. Take the bus from Terminal Tica Bus San José to Terminal Tica Bus Panamábus bus
    3d 4h
    $304–433

  3. Drive 3,898.8 km

    1. Drive from Manzanillo to Panama Citycar car 3,898.8 km
    2d 5h
    $534–771

  4. Bus to Miguel Hidalgo Y Costilla Guadalajara International Airport, fly

    1. Take the bus from Manzanillo to Guadalajara Airportbus bus
    2. Fly from Miguel Hidalgo Y Costilla Guadalajara International Airport (GDL) to Tocumen International Airport (PTY)plane plane GDL - PTY
    11h 25m
    $453–864

  5. Bus to Licenciado Gustavo Díaz Ordaz International Airport, fly

    1. Take the bus from Manzanillo to Puerto Vallartabus bus
    2. Fly from Licenciado Gustavo Díaz Ordaz International Airport (PVR) to Tocumen International Airport (PTY)plane plane PVR - PTY
    13h 50m
    $391–625

  6. Bus

    1. Take the bus from Manzanillo to Terminal Central de Autobuses del Nortebus bus
    2. Take the bus from Terminal Central de Autobuses del Norte to Tapachulabus bus
    3. Take the bus from Tapachula to San Salvadorbus bus
    4. Take the bus from El Salvador to Terminal Tica Busbus bus
    5. Take the bus from Terminal Tica Bus San José to Terminal Tica Bus Panamábus bus
    3d 11h
    $349–533

Playa De Oro International Airport (ZLO) to Tocumen International Airport (PTY) flights

Calendar22Weekly Planes
Duration9h 5mAverage Duration
Ticket$139Cheapest Price
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Questions & Answers

Map of how to get from Manzanillo to Panama City.ExpandLaunch map view
  • Distance: 2,986.9 km
  • Duration: 7h 34m

What companies run services between Manzanillo, Mexico and Panama City, Panama?

Aeroméxico and Copa Airlines fly from Playa De Oro International Airport (ZLO) to Tocumen International Airport (PTY) 3 times a day. Alternatively, you can take a bus from Manzanillo to Terminal Tica Bus Panamá via México D.F., Central De Autobuses Del Norte, Central del Norte, Diana, Politécnico, Tapachula, San Salvador, Terminal San Carlos - CCA, Terminal Atlántico Norte, and Terminal Tica Bus San José in around 3d 4h.

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