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How to get fromMassachusetts to St. Louisby plane, train (Amtrak), bus (Greyhound), car, train, or bus (Greyhound, Flixbus)

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There are 9 ways to get from Massachusetts to St. Louis by plane, train (Amtrak), bus (Greyhound), car, train, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Boston Logan Airport

    best
    1. Fly from Boston Logan Airport (BOS) to Lambert–St. Louis International Airport (STL)plane plane BOS - STL
    5h 12m
    $465–905

  2. Fly from Worcester Regional Airport

    cheapest
    1. Fly from Worcester Regional Airport (ORH) to Lambert–St. Louis International Airport (STL)plane plane ORH - STL
    7h 17m
    $125–655

  3. Train (Amtrak)

    1. Take the train from Boston to Chicago Union Stationtrain train Lake Shore Limited
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    28h 8m
    $709–1,098

  4. Bus via New York

    1. Take the bus from Boston to New Yorkbus bus Ppb 5774 / ...
    2. Take the bus from Port Authority Bus Terminal to St Louis Bus Stationbus bus Greyhound US0421
    28h 35m
    $223–353

  5. Drive  1,150.4 mi

    1. Drive from Boston to St. Louiscar car 1,150.4 mi
    20h 24m
    $210–304

  6. Fly from Bradley International Airport

    1. Fly from Bradley International Airport (BDL) to Lambert–St. Louis International Airport (STL)plane plane BDL - STL
    6h 56m
    $143–717

  7. Train to Theodore Francis Green State Airport, fly

    1. Take the train from South Station to TF Green Airporttrain train
    2. Fly from Theodore Francis Green State Airport (PVD) to Lambert–St. Louis International Airport (STL)plane plane PVD - STL
    8h 5m
    $163–769

  8. Train, train to Laguardia Airport, fly

    1. Take the train from Springfield to New Haventrain train
    2. Take the train from New Haven to 125th Street - Harlemtrain train
    3. Fly from Laguardia Airport (LGA) to Lambert–St. Louis International Airport (STL)plane plane LGA - STL
    8h 33m
    $238–642

  9. Bus

    1. Take the bus from Boston to Newark Penn Stationbus bus Greyhound US0235 / ...
    2. Take the bus from Newark Penn Station to St Louis Bus Stationbus bus Greyhound US0421
    28h 50m
    $211–338

Massachusetts to St. Louis by train (Amtrak)

Calendar7Weekly Trains
Duration28h 8mAverage Duration
Ticket$709Cheapest Price
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Comparing Your Travel Options

Map of how to get from Massachusetts to St. Louis.ExpandLaunch map view
  • Distance: 1,060.7 mi
  • Duration: 5h 12m

What companies run services between Massachusetts, USA and St. Louis, MO, USA?

American Airlines and Southwest Airlines fly from Boston Logan Airport (BOS) to Lambert–St. Louis International Airport (STL) every 3 hours. Alternatively, you can take a train from Boston to St. Louis via Chicago Union Station in around 28h 8m.

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