There are 5 ways to get from Matamoros to Panama City by plane, bus, or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly from General Servando Canales International Airport
best- Fly from General Servando Canales International Airport (MAM) to Tocumen International Airport (PTY)plane MAM - PTY
15h 30m$225–809Fly from Brownsville-South Padre Island International Airport
cheapest- Fly from Brownsville-South Padre Island International Airport (BRO) to Tocumen International Airport (PTY)plane BRO - PTY
9h 56m$180–690Bus
- Take the bus from Brownsville Bus Station to Houston - Hillcroft Avebus
- Take the bus from Houston to San Salvadorbus
- Take the bus from Terminal Tica Bus San Salvador to Terminal Tica Bus San Josébus
- Take the bus from Terminal Tica Bus San José to Terminal Tica Bus Panamábus
4d 21h$381–663Drive 3,751.9 km
- Drive from Matamoros to Panama Citycar 3,751.9 km
2d 5h$514–742Bus to Mcallen Miller International Airport, fly
- Take the bus from Brownsville to McAllen Central Stationbus
- Fly from Mcallen Miller International Airport (MFE) to Tocumen International Airport (PTY)plane MFE - PTY
10h 21m$185–749
General Servando Canales International Airport (MAM) to Tocumen International Airport (PTY) flights
Comparing Your Travel Options
The cheapest way to get from Matamoros to Panama City is to fly which costs $180 - $700 and takes 9h 56m.
The fastest way to get from Matamoros to Panama City is to fly which takes 9h 56m and costs $180 - $700.
No, there is no direct bus from Matamoros station to Panama City. However, there are services departing from Brownsville Bus Station and arriving at Terminal Tica Bus Panamá via Houston, Terminal Tica Bus San Salvador and Terminal Tica Bus San José. The journey, including transfers, takes approximately 4 days 21h.
The distance between Matamoros and Panama City is 2706 km. The road distance is 3751.9 km.
The best way to get from Matamoros to Panama City without a car is to bus which takes 4 days 21h and costs $380 - $700.
It takes approximately 15h 30m to get from Matamoros to Panama City, including transfers.
Matamoros to Panama City bus services, operated by Omnibus Express, depart from Brownsville Bus Station.
The best way to get from Matamoros to Panama City is to fly which takes 15h 30m and costs $220 - $850. Alternatively, you can bus, which costs $380 - $700 and takes 4 days 21h.
Matamoros to Panama City bus services, operated by Omnibus Express, arrive at Houston - Hillcroft Ave station.
Yes, the driving distance between Matamoros to Panama City is 3752 km. It takes approximately 2 days 5h to drive from Matamoros to Panama City.
What companies run services between Matamoros, Tamaulipas, Mexico and Panama City, Panama?
Aeroméxico, Copa Airlines, and Viva Aerobus fly from General Servando Canales International Airport (MAM) to Tocumen International Airport (PTY) once daily. Alternatively, you can take a bus from Brownsville Bus Station to Terminal Tica Bus Panamá via Houston - Hillcroft Ave, Houston, San Salvador, Terminal Tica Bus San Salvador, and Terminal Tica Bus San José in around 4d 21h.
- Website
- copaair.com
Flights from General Servando Canales International Airport to Tocumen International Airport via Mexico City
- Ave. Duration
- 14h 23m
- When
- Tuesday, Thursday, and Saturday
- Estimated price
- $170–750
Flights from General Servando Canales International Airport to Tocumen International Airport via Mexico City, Cancun
- Ave. Duration
- 19h 4m
- When
- Thursday, Friday, Sunday, and Monday
- Estimated price
- $190–800
Flights from Brownsville-South Padre Island International Airport to Tocumen International Airport via Houston
- Ave. Duration
- 6h 44m
- When
- Every day
- Estimated price
- $140–650
Flights from Brownsville-South Padre Island International Airport to Tocumen International Airport via Orlando
- Ave. Duration
- 7h 30m
- When
- Monday
- Estimated price
- $160–700
Flights from Mcallen Miller International Airport to Tocumen International Airport via Houston
- Ave. Duration
- 6h 40m
- When
- Every day
- Estimated price
- $140–650
Flights from Mcallen Miller International Airport to Tocumen International Airport via Austin
- Ave. Duration
- 7h 14m
- When
- Monday, Wednesday, Thursday, and Saturday
- Estimated price
- $150–650
- Website
- united.com
Flights from Brownsville-South Padre Island International Airport to Tocumen International Airport via Houston
- Ave. Duration
- 6h 44m
- When
- Every day
- Estimated price
- $140–650
Flights from Mcallen Miller International Airport to Tocumen International Airport via Houston
- Ave. Duration
- 6h 40m
- When
- Every day
- Estimated price
- $140–650
- Website
- aeromexico.com
Flights from General Servando Canales International Airport to Tocumen International Airport via Mexico City
- Ave. Duration
- 22h 8m
- When
- Tuesday, Thursday, and Saturday
- Estimated price
- $170–750
- Phone
- +1 800-923-1799
- [email protected]
- Website
- Omnibus Express
Bus from Brownsville Bus Station to Houston - Hillcroft Ave
- Ave. Duration
- 6h
- Frequency
- Twice daily
- Estimated price
- $70–95
- Schedules at
- Omnibus Express
Bus from Brownsville to McAllen Central Station
- Ave. Duration
- 50 min
- Frequency
- Once daily
- Estimated price
- $40–55
- Schedules at
- Omnibus Express
- Phone
- +1 213 368 1172
- [email protected]
- Website
- busesusatours.com
Bus from Houston to San Salvador
- Ave. Duration
- 3d
- Frequency
- Once a week
- Estimated price
- $180–390
- Schedules at
- busesusatours.com
- Phone
- +52 962 625 2435
- [email protected]
- Website
- Tica Bus
Bus from Terminal Tica Bus San Salvador to Terminal Tica Bus San José
- Ave. Duration
- 19h 30m
- Frequency
- 3 times a week
- Estimated price
- $60–85
- Website
- Tica Bus
Bus from Terminal Tica Bus San José to Terminal Tica Bus Panamá
- Ave. Duration
- 16h 10m
- Frequency
- Once daily
- Estimated price
- $55–80
- Website
- Tica Bus
- Phone
- +1 956-682-3481
- [email protected]
- Website
- Valley Metro Texas
Bus from Brownsville to McAllen Central Station
- Ave. Duration
- 1h 15m
- Frequency
- Once daily
- Estimated price
- $2
- Website
- Valley Metro Texas
Want to know more about travelling around Panama
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Booking & Getting There
There are 878+ hotels available in Panama City.



