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How to get fromMatanzas to Cayo Guillermoby bus, car, train, taxi, or plane

Find Transport to Cayo Guillermo

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There are 7 ways to get from Matanzas to Cayo Guillermo by bus, car, train, taxi, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, drive

    best
    1. Take the bus from Matanzas to Santa Clarabus bus
    2. Take the bus from Santa Clara to Cayo Santa Maríabus bus
    3. Drive from Cayo Santa María to Cayo Guillermocar car
    9h 41m
    $37–64

  2. Train, taxi

    1. Take the train from Matanzas to Ciego de Ávilatrain train 11 / ...
    2. Take the taxi from Morón to Cayo Guillermotaxi taxi
    9h 50m
    $68–87

  3. Drive 452.3 km

    1. Drive from Matanzas to Cayo Guillermocar car 452.3 km
    7h 11m
    $52–75

  4. Fly to Ignacio Agramonte International Airport, train, taxi

    1. Fly from Juan Gualberto Gómez International Airport (VRA) to Ignacio Agramonte International Airport (CMW)plane plane VRA - CMW
    2. Take the train from Camagüey to Moróntrain train
    3. Take the taxi from Morón to Cayo Guillermotaxi taxi
    35h 35m
    $139–444

  5. Train, bus, drive

    1. Take the train from Matanzas to Santa Claratrain train 13 / ...
    2. Take the bus from Santa Clara to Cayo Santa Maríabus bus
    3. Drive from Cayo Santa María to Cayo Guillermocar car
    10h 45m
    $37–65

  6. Bus, drive via Valentin Perla Blanca

    1. Take the bus from Matanzas to Santa Clarabus bus
    2. Take the bus from Santa Clara to Cayo Santa Maríabus bus
    3. Drive from Valentin Perla Blanca to Cayo Guillermocar car
    11h 23m
    $56–88

  7. Fly to Abel Santamaría Airport, bus, drive

    1. Fly from Juan Gualberto Gómez International Airport (VRA) to Abel Santamaría Airport (SNU)plane plane VRA - SNU
    2. Take the bus from Santa Clara to Cayo Santa Maríabus bus
    3. Drive from Cayo Santa María to Cayo Guillermocar car
    22h 34m
    $110–417

Juan Gualberto Gómez International Airport (VRA) to Ignacio Agramonte International Airport (CMW) flights

Calendar6Weekly Planes
Duration27h 10mAverage Duration
Ticket$64Cheapest Price
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Questions & Answers

Map of how to get from Matanzas to Cayo Guillermo.ExpandLaunch map view
  • Distance: 564.4 km
  • Duration: 9h 41m

What companies run services between Matanzas, Cuba and Cayo Guillermo, Cuba?

There is no direct connection from Matanzas to Cayo Guillermo. However, you can take the bus to Santa Clara, take the bus to Vc, walk to Santa Clara, take the bus to Cayo Santa María, then drive to Cayo Guillermo. Alternatively, you can take the train to Ciego de Ávila, take the train to Morón, then take the taxi to Cayo Guillermo.

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