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How to get fromMattoon to Knoxvilleby train, plane, bus, or car

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There are 9 ways to get from Mattoon to Knoxville by train, plane, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to University Of Illinois Willard Airport, fly

    best
    1. Take the train from Mattoon Amtrak Station to Champaign-Urbanatrain train
    2. Fly from University Of Illinois Willard Airport (CMI) to Mcghee Tyson Airport (TYS)plane plane CMI - TYS
    7h 38m
    $216–869

  2. Drive 435 mi

    cheapest
    1. Drive from Mattoon to Knoxvillecar car 435 mi
    8h 53m
    $80–115

  3. Train, bus

    1. Take the train from Mattoon Amtrak Station to Champaign-Urbanatrain train
    2. Take the bus from Champaign Intermodal Trans Ctr to Indianapolis Union Stationbus bus
    3. Take the bus from Indianapolis Union Station to Port Authority Bus Terminalbus bus
    4. Take the bus from New York to Knoxvillebus bus Nyc
    37h 28m
    $323–535

  4. Train, bus via Chicago

    1. Take the train from Mattoon Amtrak Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York to Knoxvillebus bus Nyc
    38h 12m
    $502–958

  5. Train to Chicago O'Hare International Airport, fly

    1. Take the train from Mattoon Amtrak Station to Chicago Union Stationtrain train
    2. Fly from Chicago O'Hare International Airport (ORD) to Mcghee Tyson Airport (TYS)plane plane ORD - TYS
    7h 34m
    $216–830

  6. Train, bus to Decatur Airport, fly

    1. Take the train from Mattoon Amtrak Station to Champaign-Urbanatrain train
    2. Take the bus from Champaign Intermodal Trans Ctr to Decatur Downtown Transportation Centerbus bus
    3. Fly from Decatur Airport (DEC) to Mcghee Tyson Airport (TYS)plane plane DEC - TYS
    10h 57m
    $228–925

  7. Train, bus to Central Illinois Regional Airport At Bloomington-Normal, fly

    1. Take the train from Mattoon Amtrak Station to Champaign-Urbanatrain train
    2. Take the bus from Champaign Intermodal Trans Ctr to Bloomington-Normalbus bus
    3. Fly from Central Illinois Regional Airport At Bloomington-Normal (BMI) to Mcghee Tyson Airport (TYS)plane plane BMI - TYS
    9h 29m
    $206–862

  8. Train, bus via Chicago #2

    1. Take the train from Mattoon Amtrak Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Croton-Harmon Amtrak Stationtrain train
    3. Take the train from Croton-Harmon to Grand Central Terminaltrain train
    4. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    38h 50m
    $458–886

  9. Train, bus via Auburn Gresham

    1. Take the train from Mattoon Amtrak Station to Champaign-Urbanatrain train
    2. Take the bus from Champaign Intermodal Trans Ctr to Chicagobus bus
    3. Take the bus from Chicago to New York City Chinatownbus bus
    4. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    42h 23m
    $259–401

University Of Illinois Willard Airport (CMI) to Mcghee Tyson Airport (TYS) flights

Calendar43Weekly Planes
Duration8h 6mAverage Duration
Ticket$138Cheapest Price
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Questions & Answers

Map of how to get from Mattoon to Knoxville.ExpandLaunch map view
  • Distance: 437 mi
  • Duration: 7h 38m

What companies run services between Mattoon, IL, USA and Knoxville, TN, USA?

There is no direct connection from Mattoon to Knoxville. However, you can take the train to Champaign-Urbana, take the taxi to University Of Illinois Willard Airport (CMI) airport, fly to Mcghee Tyson Airport (TYS), then take the taxi to Knoxville. Alternatively, you can take a train from Mattoon Amtrak Station to Knoxville via Champaign-Urbana, Champaign Intermodal Trans Ctr, Indianapolis Union Station, Port Authority Bus Terminal, 34 St-Herald Sq, East Broadway, New York, and Knoxville in around 37h 28m.

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