What is the cheapest way to get from Mattoon to Mayo Clinic?

The cheapest way to get from Mattoon to Mayo Clinic is to drive which costs $80 - $120 and takes 9h 6m.

What is the fastest way to get from Mattoon to Mayo Clinic?

The fastest way to get from Mattoon to Mayo Clinic is to train and fly which takes 8h 41m and costs $120 - $450.

Is there a direct bus between Mattoon and Mayo Clinic?

No, there is no direct bus from Mattoon station to Mayo Clinic. However, there are services departing from Phillips Gas Station - Arcola and arriving at Rochester via Milwaukee. The journey, including transfers, takes approximately 12h 8m.

How far is it from Mattoon to Mayo Clinic?

The distance between Mattoon and Mayo Clinic is 553 miles. The road distance is 453.7 miles.

How do I travel from Mattoon to Mayo Clinic without a car?

The best way to get from Mattoon to Mayo Clinic without a car is to bus which takes 12h 8m and costs $160 - $230.

How long does it take to get from Mattoon to Mayo Clinic?

It takes approximately 12h 8m to get from Mattoon to Mayo Clinic, including transfers.

Where do I catch the Mattoon to Mayo Clinic bus from?

Mattoon to Mayo Clinic bus services, operated by Tornado Bus Company, depart from Phillips Gas Station - Arcola.

Where does the Mattoon to Mayo Clinic bus arrive?

Mattoon to Mayo Clinic bus services, operated by Tornado Bus Company, arrive at Water & Chicago - Circle K station.

Can I drive from Mattoon to Mayo Clinic?

Yes, the driving distance between Mattoon to Mayo Clinic is 454 miles. It takes approximately 9h 6m to drive from Mattoon to Mayo Clinic.

Where can I stay near Mayo Clinic?

There are 53+ hotels available in Mayo Clinic.

Mattoon to Mayo Clinic - 8 ways to travel via train, bus, car, and plane

There are 8 ways to get from Mattoon to Mayo Clinic by bus, train, car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

Bus
best
1. Take the bus from Phillips Gas Station - Arcola to Water & Chicago - Circle Kbus Milwaukee
2. Take the bus from Milwaukee to Rochesterbus Jefferson Lines 966
12h 8m
$161–223
Drive 451 mi
cheapest
1. Drive from Mattoon to Mayo Cliniccar 451 mi
9h 6m
$83–119
Train, bus
1. Take the train from Mattoon Amtrak Station to Chicago Union Stationtrain
2. Take the train from Chicago Union Station to St. Paul-Minneapolistrain
3. Take the bus from St. Paul to Rochesterbus
14h 31m
$344–537
Train to University Of Illinois Willard Airport, fly
1. Take the train from Mattoon Amtrak Station to Champaign-Urbanatrain
2. Fly from University Of Illinois Willard Airport (CMI) to Rochester (RST)plane CMI - RST
8h 44m
$99–440
Train, bus via Madison
1. Take the train from Mattoon Amtrak Station to Chicago Union Stationtrain
2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus
3. Take the bus from Madison to Rochesterbus
13h 13m
$171–277
Train, bus via Madison #2
1. Take the train from Mattoon Amtrak Station to Champaign-Urbanatrain
2. Take the bus from Champaign Intermodal Trans Ctr to Chicago Bus Stationbus
3. Take the bus from Chicago Bus Station to Madisonbus
4. Take the bus from Madison to Rochesterbus
14h 29m
$146–218
Train to Chicago O'Hare International Airport, fly
1. Take the train from Mattoon Amtrak Station to Homewoodtrain
2. Fly from Chicago O'Hare International Airport (ORD) to Rochester (RST)plane ORD - RST
8h 41m
$125–448
Train, bus to Central Illinois Regional Airport At Bloomington-Normal, fly
1. Take the train from Mattoon Amtrak Station to Champaign-Urbanatrain
2. Take the bus from Champaign Intermodal Trans Ctr to Bloomington-Normalbus
3. Fly from Central Illinois Regional Airport At Bloomington-Normal (BMI) to Rochester (RST)plane BMI - RST
14h 3m
$86–433

Mattoon to Mayo Clinic by train, bus, and foot

7Weekly Services

14h 31mAverage Duration

$344Cheapest Price

See schedules

Comparing Your Travel Options

Map of how to get from Mattoon to Mayo Clinic.

Launch map view

Distance: 549.4 mi
Duration: 12h 8m

What companies run services between Mattoon, IL, USA and Mayo Clinic, MN, USA?

You can take a vehicle from Mattoon to Mayo Clinic via Phillips Gas Station - Arcola, Water & Chicago - Circle K, Milwaukee, and Rochester in around 12h 8m.

Airlines

Train operators

Bus operators

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