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How to get fromMattoon to Mayo Clinicby train, plane, bus, or car

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There are 8 ways to get from Mattoon to Mayo Clinic by train, plane, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to University Of Illinois Willard Airport, fly

    best
    1. Take the train from Mattoon Amtrak Station to Champaign-Urbanatrain train
    2. Fly from University Of Illinois Willard Airport (CMI) to Rochester (RST)plane plane CMI - RST
    7h 6m
    $86–428

  2. Train, bus to Central Illinois Regional Airport At Bloomington-Normal, fly

    cheapest
    1. Take the train from Mattoon Amtrak Station to Champaign-Urbanatrain train
    2. Take the bus from Champaign Intermodal Trans Ctr to Bloomington-Normalbus bus
    3. Fly from Central Illinois Regional Airport At Bloomington-Normal (BMI) to Rochester (RST)plane plane BMI - RST
    10h 3m
    $71–411

  3. Bus

    1. Take the bus from Phillips Gas Station - Arcola to Water & Chicago - Circle Kbus bus Milwaukee
    2. Take the bus from Milwaukee to Rochesterbus bus Jefferson Lines 966
    12h 8m
    $161–223

  4. Train, bus

    1. Take the train from Mattoon Amtrak Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    3. Take the bus from St. Paul to Rochesterbus bus
    14h 31m
    $184–392

  5. Drive 451 mi

    1. Drive from Mattoon to Mayo Cliniccar car 451 mi
    9h 6m
    $83–119

  6. Train to Chicago O'Hare International Airport, fly

    1. Take the train from Mattoon Amtrak Station to Chicago Union Stationtrain train
    2. Fly from Chicago O'Hare International Airport (ORD) to Rochester (RST)plane plane ORD - RST
    8h 12m
    $89–427

  7. Train, bus via Madison

    1. Take the train from Mattoon Amtrak Station to Chicago Union Stationtrain train
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    13h 13m
    $121–232

  8. Train, bus via Madison #2

    1. Take the train from Mattoon Amtrak Station to Champaign-Urbanatrain train
    2. Take the bus from Champaign Intermodal Trans Ctr to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Madisonbus bus
    4. Take the bus from Madison to Rochesterbus bus
    14h 29m
    $130–211

Mattoon to Mayo Clinic by train, bus, and foot

Calendar7Weekly Services
Duration14h 31mAverage Duration
Ticket$184Cheapest Price
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Questions & Answers

Map of how to get from Mattoon to Mayo Clinic.ExpandLaunch map view
  • Distance: 404.4 mi
  • Duration: 7h 6m

What companies run services between Mattoon, IL, USA and Mayo Clinic, MN, USA?

You can take a vehicle from Mattoon to Mayo Clinic via Phillips Gas Station - Arcola, Water & Chicago - Circle K, Milwaukee, and Rochester in around 12h 8m.

Airlines
Train operators
Bus operators

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