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How to get fromMattoon to Panama Cityby train, plane, car, or bus

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There are 8 ways to get from Mattoon to Panama City by train, plane, car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Chicago Midway International Airport, fly to Northwest Florida Beaches International Airport

    best
    1. Take the train from Mattoon Amtrak Station to Homewoodtrain train
    2. Fly from Chicago Midway International Airport (MDW) to Northwest Florida Beaches International Airport (ECP)plane plane MDW - ECP
    8h 14m
    $219–689

  2. Drive 733 mi

    cheapest
    1. Drive from Mattoon to Panama Citycar car 733 mi
    13h 44m
    $134–194

  3. Train, bus to Central Illinois Regional Airport At Bloomington-Normal, fly to Northwest Florida Beaches International Airport

    1. Take the train from Mattoon Amtrak Station to Champaign-Urbanatrain train
    2. Take the bus from Champaign Intermodal Trans Ctr to Bloomington-Normalbus bus
    3. Fly from Central Illinois Regional Airport At Bloomington-Normal (BMI) to Northwest Florida Beaches International Airport (ECP)plane plane BMI - ECP
    10h 23m
    $167–525

  4. Train, bus to Indianapolis, fly to Northwest Florida Beaches International Airport

    1. Take the train from Mattoon Amtrak Station to Champaign-Urbanatrain train
    2. Take the bus from Champaign Intermodal Trans Ctr to Indianapolis Union Stationbus bus
    3. Fly from Indianapolis (IND) to Northwest Florida Beaches International Airport (ECP)plane plane IND - ECP
    8h 50m
    $192–622

  5. Train, bus to Lambert–St. Louis International Airport, fly to Northwest Florida Beaches International Airport

    1. Take the train from Mattoon Amtrak Station to Carbondaletrain train
    2. Take the bus from Carbondale Intermodal Station to St Louis Bus Stationbus bus
    3. Fly from Lambert–St. Louis International Airport (STL) to Northwest Florida Beaches International Airport (ECP)plane plane STL - ECP
    9h 9m
    $216–698

  6. Train, bus to Lambert–St. Louis International Airport, fly to Destin–Fort Walton Beach Airport, drive

    1. Take the train from Mattoon Amtrak Station to Carbondaletrain train
    2. Take the bus from Carbondale Intermodal Station to St Louis Bus Stationbus bus
    3. Fly from Lambert–St. Louis International Airport (STL) to Destin–Fort Walton Beach Airport (VPS)plane plane STL - VPS
    4. Drive from Destin–Fort Walton Beach Airport (VPS) to Panama Citycar car
    10h 10m
    $158–626

  7. Train, bus to Midamerica St. Louis Airport, fly to Destin–Fort Walton Beach Airport, drive

    1. Take the train from Mattoon Amtrak Station to Carbondaletrain train
    2. Take the bus from Carbondale Intermodal Station to St Louis Bus Stationbus bus
    3. Fly from Midamerica St. Louis Airport (BLV) to Destin–Fort Walton Beach Airport (VPS)plane plane BLV - VPS
    4. Drive from Destin–Fort Walton Beach Airport (VPS) to Panama Citycar car
    10h 32m
    $161–544

  8. Train, bus to Lambert–St. Louis International Airport, fly to Pensacola International Airport, drive

    1. Take the train from Mattoon Amtrak Station to Carbondaletrain train
    2. Take the bus from Carbondale Intermodal Station to St Louis Bus Stationbus bus
    3. Fly from Lambert–St. Louis International Airport (STL) to Pensacola International Airport (PNS)plane plane STL - PNS
    4. Drive from Pensacola-Airport-PNS to Panama Citycar car
    11h 9m
    $155–587

Chicago Midway International Airport (MDW) to Northwest Florida Beaches International Airport (ECP) flights

Calendar36Weekly Planes
Duration3h 49mAverage Duration
Ticket$100Cheapest Price
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Questions & Answers

Map of how to get from Mattoon to Panama City.ExpandLaunch map view
  • Distance: 1,002.2 mi
  • Duration: 8h 14m

What companies run services between Mattoon, IL, USA and Panama City, FL, USA?

There is no direct connection from Mattoon to Panama City. However, you can take the train to Homewood, take the train to Museum Campus/11th St., walk to Roosevelt, take the subway to Midway, walk to Chicago-Midway-Airport-MDW airport, fly to Northwest Florida Beaches International Airport (ECP), then take the taxi to Panama City. Alternatively, you can drive from Mattoon to Panama City in around 13h 44m.

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