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How to get fromMayo Clinic Florida to Orlandoby train (Amtrak), bus (Flixbus), or car

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There are 3 ways to get from Mayo Clinic Florida to Orlando by train (Amtrak), bus (Flixbus), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train (Amtrak)

    best
    1. Take the train from Jacksonville to Orlandotrain train Floridian / ...
    3h 37m
    $107–173
  2. Drive 137.2 mi

    cheapest
    1. Drive from Mayo Clinic Florida to Orlandocar car 137.2 mi
    2h 19m
    $25–37
  3. Bus

    1. Take the bus from Beach Blvd + Suni Pines Blvd to JRTC Bay Mbus bus Fcf / ...
    2. Take the bus from Jacksonville to Orlando Bus Stationbus bus FlixBus 2433 / ...
    4h 40m
    $31–52

Questions & Answers

What companies run services between Mayo Clinic Florida, FL, USA and Orlando, FL, USA?

Amtrak operates a train from Jacksonville to Orlando twice daily. Tickets cost $45–100 and the journey takes 3h 7m. Alternatively, you can take a vehicle from Mayo Clinic Florida to Orlando Bus Station via Beach Blvd + Suni Pines Blvd, JRTC Bay M, and Jacksonville in around 4h 40m.

Train operators
Bus operators

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