What is the cheapest way to get from Mayo Clinic to Appleton?

The cheapest way to get from Mayo Clinic to Appleton is to drive which costs $40 - $65 and takes 4h 39m.

What is the fastest way to get from Mayo Clinic to Appleton?

The fastest way to get from Mayo Clinic to Appleton is to bus and fly which takes 3h 53m and costs $110 - $440.

Is there a direct bus between Mayo Clinic and Appleton?

No, there is no direct bus from Mayo Clinic to Appleton. However, there are services departing from Rochester and arriving at Oshkosh via Milwaukee. The journey, including transfers, takes approximately 8h 58m.

How far is it from Mayo Clinic to Appleton?

The distance between Mayo Clinic and Appleton is 385 miles. The road distance is 233.9 miles.

How do I travel from Mayo Clinic to Appleton without a car?

The best way to get from Mayo Clinic to Appleton without a car is to bus which takes 8h 58m and costs $130 - $180.

How long does it take to get from Mayo Clinic to Appleton?

It takes approximately 8h 58m to get from Mayo Clinic to Appleton, including transfers.

Where do I catch the Mayo Clinic to Appleton bus from?

Mayo Clinic to Appleton bus services, operated by Jefferson Lines, depart from Rochester station.

Bus or fly from Mayo Clinic to Appleton?

The best way to get from Mayo Clinic to Appleton is to bus which takes 8h 58m and costs $130 - $180. Alternatively, you can fly, which costs $60 - $390 and takes 5h 25m.

Where does the Mayo Clinic to Appleton bus arrive?

Mayo Clinic to Appleton bus services, operated by Jefferson Lines, arrive at Milwaukee station.

Can I drive from Mayo Clinic to Appleton?

Yes, the driving distance between Mayo Clinic to Appleton is 234 miles. It takes approximately 4h 39m to drive from Mayo Clinic to Appleton.

Where can I stay near Appleton?

There are 54+ hotels available in Appleton.

Mayo Clinic to Appleton - 7 ways to travel via bus, car, plane, and taxi

How to get fromMayo Clinic to Appleton

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There are 7 ways to get from Mayo Clinic to Appleton by bus, car, plane, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

Bus
best
1. Take the bus from Rochester to Milwaukeebus Jefferson Lines 965
2. Take the bus from Milwaukee to Oshkoshbus Lab 210
8h 58m
$135–179
Drive 232.6 mi
cheapest
1. Drive from Mayo Clinic to Appletoncar 232.6 mi
4h 39m
$43–62
Fly Rochester to Appleton International Airport
1. Fly from Rochester (RST) to Appleton International Airport (ATW)plane RST - ATW
5h 25m
$60–385
Bus, taxi
1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus
2. Take the bus from Minneapolis Bus Station to Green Bay Transit Centerbus
3. Take the taxi from Green Bay Transit Center to Appletontaxi
10h 6m
$222–282
Fly Rochester to Green Bay, taxi
1. Fly from Rochester (RST) to Green Bay (GRB)plane RST - GRB
2. Take the taxi from Green Bay (GRB) to Appletontaxi
6h 52m
$146–487
Bus to Minneapolis–Saint Paul International Airport, fly to Appleton International Airport
1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus
2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Appleton International Airport (ATW)plane MSP - ATW
3h 53m
$114–438
Bus to Minneapolis–Saint Paul International Airport, fly to Green Bay, taxi
1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus
2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Green Bay (GRB)plane MSP - GRB
3. Take the taxi from Green Bay (GRB) to Appletontaxi
4h 23m
$200–550

Rochester (RST) to Appleton International Airport (ATW) flights

40Weekly Planes

5h 18mAverage Duration

$49Cheapest Price

See schedules

Comparing Your Travel Options

Map of how to get from Mayo Clinic to Appleton.

Launch map view

Distance: 382.4 mi
Duration: 8h 58m

What companies run services between Mayo Clinic, MN, USA and Appleton, WI, USA?

You can take a vehicle from Mayo Clinic to Appleton via Rochester, Milwaukee, and Oshkosh in around 8h 58m. Alternatively, American Airlines and Delta fly from Rochester (RST) to Appleton International Airport (ATW) every 4 hours.

Airlines

Bus operators

Other operators

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How to get fromMayo Clinic to Appletonby bus, car, plane, or taxi

There are 7 ways to get from Mayo Clinic to Appleton by bus, car, plane, or taxi

Bus

Drive 232.6 mi

Fly Rochester to Appleton International Airport

Bus, taxi

Fly Rochester to Green Bay, taxi

Bus to Minneapolis–Saint Paul International Airport, fly to Appleton International Airport

Bus to Minneapolis–Saint Paul International Airport, fly to Green Bay, taxi