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How to get fromMayo Clinic to Bostonby plane, bus, train, bus (Greyhound, Flixbus), or car

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There are 7 ways to get from Mayo Clinic to Boston by plane, bus, train, bus (Greyhound, Flixbus), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Rochester

    best
    1. Fly from Rochester (RST) to Boston Logan Airport (BOS)plane plane RST - BOS
    6h 11m
    $101–537

  2. Bus, train via Madison

    1. Take the bus from Rochester to Madisonbus bus
    2. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus
    3. Take the train from Chicago Union Station to Bostontrain train
    32h 1m
    $340–734

  3. Bus

    1. Take the bus from Rochester to Milwaukeebus bus
    2. Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to New York Midtownbus bus
    4. Take the bus from New York Midtown to Bostonbus bus
    34h 58m
    $253–398

  4. Drive  1,326.8 mi

    1. Drive from Mayo Clinic to Bostoncar car 1,326.8 mi
    22h 32m
    $243–350

  5. Bus to Minneapolis–Saint Paul International Airport, fly

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Boston Logan Airport (BOS)plane plane MSP - BOS
    5h 11m
    $430–1,050

  6. Bus to Dane County Regional Airport-Truax Field, fly

    1. Take the bus from Rochester to Madisonbus bus
    2. Fly from Dane County Regional Airport-Truax Field (MSN) to Boston Logan Airport (BOS)plane plane MSN - BOS
    8h 54m
    $176–726

  7. Bus, train

    1. Take the bus from Rochester to St. Paulbus bus
    2. Take the train from St. Paul-Minneapolis to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Bostontrain train
    33h 12m
    $389–879

Mayo Clinic to Boston by foot, bus, and train

Calendar7Weekly Services
Duration32h 1mAverage Duration
Ticket$340Cheapest Price
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Comparing Your Travel Options

Map of how to get from Mayo Clinic to Boston.ExpandLaunch map view
  • Distance: 1,093.5 mi
  • Duration: 6h 11m

What companies run services between Mayo Clinic, MN, USA and Boston, MA, USA?

Delta, United Airlines, and American Airlines fly from Rochester (RST) to Boston Logan Airport (BOS) every 4 hours. Alternatively, you can take a vehicle from Mayo Clinic to Boston via Rochester, Milwaukee, Milwaukee Intermodal Station, Chicago Bus Station, and New York Midtown in around 34h 58m.

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