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How to get fromMayo Clinic to Bostonby plane, train, bus, bus (Greyhound, Flixbus), or car

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There are 9 ways to get from Mayo Clinic to Boston by plane, train, bus, bus (Greyhound, Flixbus), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Rochester to Theodore Francis Green State Airport, train

    best
    1. Fly from Rochester (RST) to Theodore Francis Green State Airport (PVD)plane plane RST - PVD
    2. Take the train from TF Green Airport to South Stationtrain train
    10h 9m
    $85–423

  2. Bus, train via Madison

    1. Take the bus from Rochester to Madisonbus bus
    2. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus
    3. Take the train from Chicago Union Station to Bostontrain train
    32h 1m
    $630–1,034

  3. Bus

    1. Take the bus from Rochester to Milwaukeebus bus
    2. Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to New York Midtownbus bus
    4. Take the bus from New York Midtown to Bostonbus bus
    34h 56m
    $263–399

  4. Drive  1,326.8 mi

    1. Drive from Mayo Clinic to Bostoncar car 1,326.8 mi
    22h 32m
    $243–350

  5. Bus to Minneapolis–Saint Paul International Airport, fly to Theodore Francis Green State Airport, train

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Theodore Francis Green State Airport (PVD)plane plane MSP - PVD
    3. Take the train from TF Green Airport to South Stationtrain train
    7h 50m
    $149–506

  6. Bus to Minneapolis–Saint Paul International Airport, fly to Bradley International Airport, bus

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Bradley International Airport (BDL)plane plane MSP - BDL
    3. Take the bus from Hartford Union Station to Bostonbus bus
    8h 40m
    $217–878

  7. Bus to Minneapolis–Saint Paul International Airport, fly to Portland, bus

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Portland (PWM)plane plane MSP - PWM
    3. Take the bus from Portland, ME to Boston, MA - South Stationbus bus
    8h 55m
    $205–753

  8. Bus to Minneapolis–Saint Paul International Airport, fly to Laguardia Airport, train

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Laguardia Airport (LGA)plane plane MSP - LGA
    3. Take the train from Ny Moynihan Train Hall At Penn Station to Bostontrain train
    10h 24m
    $413–906

  9. Bus, train

    1. Take the bus from Rochester to St. Paulbus bus
    2. Take the train from St. Paul-Minneapolis to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Bostontrain train
    33h 12m
    $799–1,289

Mayo Clinic to Boston by foot, bus, and train

Calendar7Weekly Services
Duration32h 1mAverage Duration
Ticket$630Cheapest Price
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Comparing Your Travel Options

Map of how to get from Mayo Clinic to Boston.ExpandLaunch map view
  • Distance: 1,136.1 mi
  • Duration: 10h 9m

What companies run services between Mayo Clinic, MN, USA and Boston, MA, USA?

You can take a vehicle from Mayo Clinic to Boston via Rochester, Milwaukee, Milwaukee Intermodal Station, Chicago Bus Station, and New York Midtown in around 34h 56m.

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