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How to get fromMayo Clinic to Charlestonby plane, bus, train, or car

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There are 5 ways to get from Mayo Clinic to Charleston by plane, bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Rochester to Charleston International Airport

    best
    1. Fly from Rochester (RST) to Charleston International Airport (CHS)plane plane RST - CHS
    10h 46m
    $103–519

  2. Bus, train

    1. Take the bus from Rochester to St. Paulbus bus
    2. Take the train from St. Paul-Minneapolis to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Petersburg Amtrak Stationtrain train
    4. Take the train from Petersburg Amtrak Station to Charleston Amtrak Stationtrain train
    39h 49m
    $579–1,189

  3. Drive 1,218.5 mi

    1. Drive from Mayo Clinic to Charlestoncar car 1,218.5 mi
    21h 39m
    $223–322

  4. Bus to Minneapolis–Saint Paul International Airport, fly to Charleston International Airport

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Charleston International Airport (CHS)plane plane MSP - CHS
    6h 42m
    $172–652

  5. Fly Rochester to Hilton Head Airport, drive

    1. Fly from Rochester (RST) to Hilton Head Airport (HHH)plane plane RST - HHH
    2. Drive from Hilton Head Airport (HHH) to Charlestoncar car
    8h 53m
    $114–524

Rochester (RST) to Charleston International Airport (CHS) flights

Calendar28Weekly Planes
Duration9h 54mAverage Duration
Ticket$102Cheapest Price
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Questions & Answers

Map of how to get from Mayo Clinic to Charleston.ExpandLaunch map view
  • Distance: 1,038 mi
  • Duration: 10h 46m

What companies run services between Mayo Clinic, MN, USA and Charleston, SC, USA?

Delta, American Airlines, and United Airlines fly from Rochester (RST) to Charleston International Airport (CHS) 4 times a day.

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