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How to get fromMayo Clinic to Chicagoby plane, bus, train, car, or bus (Greyhound, Flixbus)

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There are 8 ways to get from Mayo Clinic to Chicago by plane, bus, train, car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Rochester to Chicago O'Hare International Airport

    best
    1. Fly from Rochester (RST) to Chicago O'Hare International Airport (ORD)plane plane RST - ORD
    3h 43m
    $38–292

  2. Bus, train via Milwaukee

    1. Take the bus from Rochester to Milwaukeebus bus Jefferson Lines 965
    2. Take the train from Milwaukee to Chicago Union Stationtrain train Hiawatha Service / ...
    8h 20m
    $115–171

  3. Bus, train

    1. Take the bus from Rochester to St. Paulbus bus Jefferson Lines 966
    2. Take the train from St. Paul-Minneapolis to Chicago Union Stationtrain train Borealis / ...
    10h 8m
    $249–389

  4. Drive  346.9 mi

    1. Drive from Mayo Clinic to Chicagocar car 346.9 mi
    5h 42m
    $60–86

  5. Bus to Minneapolis–Saint Paul International Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Chicago O'Hare International Airport (ORD)plane plane MSP - ORD
    4h 42m
    $272–855

  6. Bus to Minneapolis–Saint Paul International Airport, fly to Chicago Midway International Airport

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Chicago Midway International Airport (MDW)plane plane MSP - MDW
    4h 37m
    $117–495

  7. Bus via Milwaukee

    1. Take the bus from Rochester to Milwaukeebus bus Jefferson Lines 965
    2. Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus bus Greyhound US0150
    8h 21m
    $84–121

  8. Bus

    1. Take the bus from Rochester to Madisonbus bus Jefferson Lines 965
    2. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus Van Galder
    8h 57m
    $80–134

Mayo Clinic to Chicago by foot, bus, and train

Calendar7Weekly Services
Duration8h 20mAverage Duration
Ticket$115Cheapest Price
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Comparing Your Travel Options

Map of how to get from Mayo Clinic to Chicago.ExpandLaunch map view
  • Distance: 294.1 mi
  • Duration: 3h 43m

What companies run services between Mayo Clinic, MN, USA and Chicago, IL, USA?

American Airlines and Delta fly from Rochester (RST) to Chicago O'Hare International Airport (ORD) 4 times a day. Alternatively, you can take a vehicle from Mayo Clinic to Chicago Bus Station via Rochester, Milwaukee, and Milwaukee Intermodal Station in around 8h 21m.

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