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How to get fromMayo Clinic to Chicagoby plane, bus (Greyhound, Flixbus), bus, train, or car

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There are 7 ways to get from Mayo Clinic to Chicago by plane, bus (Greyhound, Flixbus), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Rochester to Chicago O'Hare International Airport

    best
    1. Fly from Rochester (RST) to Chicago O'Hare International Airport (ORD)plane plane RST - ORD
    3h 37m
    $73–492

  2. Drive 347 mi

    cheapest
    1. Drive from Mayo Clinic to Chicagocar car 347 mi
    5h 42m
    $64–92

  3. Bus

    1. Take the bus from Rochester, MN to Wisconsin Dellsbus bus Minneapolis
    2. Take the bus from Wisconsin Dells to Chicago Bus Stationbus bus Greyhound US0150
    8h 43m
    $77–130

  4. Bus, train

    1. Take the bus from Rochester to St. Paulbus bus Jefferson 966 / ...
    2. Take the train from St. Paul-Minneapolis to Chicago Union Stationtrain train Borealis / ...
    9h 55m
    $159–309

  5. Bus to Minneapolis–Saint Paul International Airport, fly to Chicago Midway International Airport

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Chicago Midway International Airport (MDW)plane plane MSP - MDW
    4h 30m
    $107–405

  6. Bus to Minneapolis–Saint Paul International Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Chicago O'Hare International Airport (ORD)plane plane MSP - ORD
    4h 41m
    $272–455

  7. Bus via Madison

    1. Take the bus from Rochester, MN to UW-Madisonbus bus Minneapolis / ...
    2. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus Van Galder
    9h 41m
    $84–139

Mayo Clinic to Chicago by foot and bus

Calendar14Weekly Services
Duration8h 43mAverage Duration
Ticket$77Cheapest Price
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Questions & Answers

Map of how to get from Mayo Clinic to Chicago.ExpandLaunch map view
  • Distance: 294.2 mi
  • Duration: 3h 37m

What companies run services between Mayo Clinic, MN, USA and Chicago, IL, USA?

American Airlines and United Airlines fly from Rochester (RST) to Chicago O'Hare International Airport (ORD) 4 times a day. Alternatively, you can take a vehicle from Mayo Clinic to Chicago Bus Station via Rochester, MN and Wisconsin Dells in around 8h 43m.

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