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How to get fromMayo Clinic to Clevelandby plane, bus, train, car, bus (Greyhound, Flixbus), or bus (Flixbus, Greyhound)

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There are 7 ways to get from Mayo Clinic to Cleveland by plane, bus, train, car, bus (Greyhound, Flixbus), or bus (Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Rochester

    best
    1. Fly from Rochester (RST) to Cleveland-Hopkins International Airport (CLE)plane plane RST - CLE
    6h 8m
    $84–520

  2. Bus, train via Madison

    1. Take the bus from Rochester to Madisonbus bus
    2. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus
    3. Take the train from Chicago Union Station to Cleveland Amtraktrain train
    16h 4m
    $260–424

  3. Bus, train

    1. Take the bus from Rochester to St. Paulbus bus
    2. Take the train from St. Paul-Minneapolis to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Cleveland Amtraktrain train
    17h 15m
    $429–679

  4. Drive  689.2 mi

    1. Drive from Mayo Clinic to Clevelandcar car 689.2 mi
    11h 25m
    $126–182

  5. Bus to Minneapolis–Saint Paul International Airport, fly

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Cleveland-Hopkins International Airport (CLE)plane plane MSP - CLE
    4h 55m
    $603–1,053

  6. Bus via Milwaukee

    1. Take the bus from Rochester to Milwaukeebus bus
    2. Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago to Clevelandbus bus
    16h 23m
    $113–199

  7. Bus

    1. Take the bus from Rochester to Madisonbus bus
    2. Take the bus from Madison to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Cleveland Bus Stationbus bus
    18h 24m
    $137–212

Mayo Clinic to Cleveland by foot, bus, and train

Calendar7Weekly Services
Duration16h 4mAverage Duration
Ticket$260Cheapest Price
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Comparing Your Travel Options

Map of how to get from Mayo Clinic to Cleveland.ExpandLaunch map view
  • Distance: 587.9 mi
  • Duration: 6h 8m

What companies run services between Mayo Clinic, MN, USA and Cleveland, OH, USA?

American Airlines and Delta fly from Rochester (RST) to Cleveland-Hopkins International Airport (CLE) every 4 hours. Alternatively, you can take a vehicle from Mayo Clinic to Cleveland via Rochester, Milwaukee, Milwaukee Intermodal Station, and Chicago in around 16h 23m.

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