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How to get fromMayo Clinic to Cleveland Clinicby plane, bus (Greyhound, Flixbus), bus, train, or car

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There are 7 ways to get from Mayo Clinic to Cleveland Clinic by plane, bus (Greyhound, Flixbus), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Rochester

    best
    1. Fly from Rochester (RST) to Cleveland-Hopkins International Airport (CLE)plane plane RST - CLE
    6h 4m
    $94–540

  2. Bus

    1. Take the bus from Rochester, MN to Milwaukee, WI - Amtrakbus bus
    2. Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago to Clevelandbus bus
    17h 57m
    $120–210

  3. Bus, train

    1. Take the bus from Rochester to St. Paulbus bus
    2. Take the train from St. Paul-Minneapolis to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Cleveland Amtraktrain train
    18h 2m
    $272–542

  4. Drive 692.6 mi

    1. Drive from Mayo Clinic to Cleveland Cliniccar car 692.6 mi
    11h 28m
    $127–183

  5. Bus to Minneapolis–Saint Paul International Airport, fly

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Cleveland-Hopkins International Airport (CLE)plane plane MSP - CLE
    5h 22m
    $603–1,053

  6. Bus, train via Madison

    1. Take the bus from Rochester, MN to UW-Madisonbus bus
    2. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus
    3. Take the train from Chicago Union Station to Cleveland Amtraktrain train
    17h 58m
    $197–372

  7. Bus via Lake Delton

    1. Take the bus from Rochester, MN to Wisconsin Dellsbus bus
    2. Take the bus from Wisconsin Dells to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Cleveland Bus Stationbus bus
    18h 5m
    $130–228

Mayo Clinic to Cleveland Clinic by foot and bus

Calendar7Weekly Services
Duration17h 57mAverage Duration
Ticket$120Cheapest Price
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Questions & Answers

Map of how to get from Mayo Clinic to Cleveland Clinic.ExpandLaunch map view
  • Distance: 594.2 mi
  • Duration: 6h 4m

What companies run services between Mayo Clinic, MN, USA and Cleveland Clinic, OH, USA?

Delta, United Airlines, and American Airlines fly from Rochester (RST) to Cleveland-Hopkins International Airport (CLE) every 4 hours. Alternatively, you can take a vehicle from Mayo Clinic to Cleveland Clinic via Rochester, MN, Milwaukee Intermodal Station, Chicago, Cleveland, Chester Av & E 15Th St, and E 105Th St & Carnegie Av in around 17h 57m.

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