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How to get fromMayo Clinic to Columbiaby plane, bus (Greyhound, Flixbus), bus, train, or car

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There are 6 ways to get from Mayo Clinic to Columbia by plane, bus (Greyhound, Flixbus), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Rochester

    best
    1. Fly from Rochester (RST) to Columbia (CAE)plane plane RST - CAE
    7h 19m
    $233–1,139

  2. Drive 1,108.9 mi

    cheapest
    1. Drive from Mayo Clinic to Columbiacar car 1,108.9 mi
    19h 50m
    $203–293

  3. Bus

    1. Take the bus from Rochester to Milwaukeebus bus
    2. Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Atlanta Bus Stationbus bus
    4. Take the bus from Atlanta Bus Station to Camdenbus bus
    5. Take the bus from Camden to Columbia, SCbus bus Nyc
    33h 54m
    $248–449

  4. Bus, train via Madison

    1. Take the bus from Rochester to Madisonbus bus
    2. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus
    3. Take the train from Chicago Union Station to Columbia Stationtrain train
    38h 56m
    $480–984

  5. Bus to Minneapolis–Saint Paul International Airport, fly

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Columbia (CAE)plane plane MSP - CAE
    8h 30m
    $332–1,452

  6. Bus, train

    1. Take the bus from Rochester to St. Paulbus bus
    2. Take the train from St. Paul-Minneapolis to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Columbia Stationtrain train
    39h 55m
    $559–1,159

Mayo Clinic to Columbia by foot, bus, and train

Calendar7Weekly Services
Duration38h 56mAverage Duration
Ticket$480Cheapest Price
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Questions & Answers

Map of how to get from Mayo Clinic to Columbia.ExpandLaunch map view
  • Distance: 936.3 mi
  • Duration: 7h 19m

What companies run services between Mayo Clinic, MN, USA and Columbia, SC, USA?

United Airlines, American Airlines, and Delta fly from Rochester (RST) to Columbia (CAE) every 4 hours. Alternatively, you can take a vehicle from Mayo Clinic to Sumter Laurel South via Rochester, Milwaukee, Milwaukee Intermodal Station, Chicago Bus Station, Atlanta Bus Station, Camden, Columbia, SC, and Broad Marley South in around 33h 54m.

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