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How to get fromMayo Clinic to Des Moinesby bus, car, or plane

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There are 5 ways to get from Mayo Clinic to Des Moines by bus, car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Rochester to Albert Leabus bus Lta 234
    2. Take the bus from Albert Lea to Des Moinesbus bus Jefferson Lines 803 / ...
    5h 53m

  2. Drive 207.3 mi

    cheapest
    1. Drive from Mayo Clinic to Des Moinescar car 207.3 mi
    3h 27m
    $38–55

  3. Fly from Rochester

    1. Fly from Rochester (RST) to Des Moines (DSM)plane plane RST - DSM
    5h 49m
    $168–943

  4. Bus via Clear Lake

    1. Take the bus from Rochester to Albert Leabus bus
    2. Take the bus from Albert Lea to Clear Lake Jct.bus bus
    3. Take the bus from Clear Lake Jct. to Des Moinesbus bus
    6h 13m

  5. Bus to Minneapolis–Saint Paul International Airport, fly

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Des Moines (DSM)plane plane MSP - DSM
    3h 47m
    $147–621

Rochester (RST) to Des Moines (DSM) flights

Calendar62Weekly Planes
Duration6h 34mAverage Duration
Ticket$150Cheapest Price
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Questions & Answers

Map of how to get from Mayo Clinic to Des Moines.ExpandLaunch map view
  • Distance: 223.1 mi
  • Duration: 5h 53m

What companies run services between Mayo Clinic, MN, USA and Des Moines, IA, USA?

You can take a vehicle from Mayo Clinic to Des Moines via Rochester and Albert Lea in around 5h 53m. Alternatively, Delta, American Airlines, and United Airlines fly from Rochester (RST) to Des Moines (DSM) every 3 hours.

Airlines
Bus operators

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