What is the cheapest way to get from Mayo Clinic to Des Moines?

The cheapest way to get from Mayo Clinic to Des Moines is to drive which costs $35 - $55 and takes 3h 27m.

What is the fastest way to get from Mayo Clinic to Des Moines?

The fastest way to get from Mayo Clinic to Des Moines is to drive which takes 3h 27m and costs $35 - $55.

Is there a direct bus between Mayo Clinic and Des Moines?

No, there is no direct bus from Mayo Clinic to Des Moines. However, there are services departing from Rochester and arriving at Des Moines via Saint Paul Union Depot. The journey, including transfers, takes approximately 7h 8m.

How far is it from Mayo Clinic to Des Moines?

The distance between Mayo Clinic and Des Moines is 325 miles. The road distance is 208.5 miles.

How do I travel from Mayo Clinic to Des Moines without a car?

The best way to get from Mayo Clinic to Des Moines without a car is to bus which takes 7h 8m and costs $70 - $110.

How long does it take to get from Mayo Clinic to Des Moines?

It takes approximately 7h 8m to get from Mayo Clinic to Des Moines, including transfers.

Where do I catch the Mayo Clinic to Des Moines bus from?

Mayo Clinic to Des Moines bus services, operated by Jefferson Lines, depart from Rochester station.

Bus or fly from Mayo Clinic to Des Moines?

The best way to get from Mayo Clinic to Des Moines is to bus which takes 7h 8m and costs $70 - $110. Alternatively, you can fly, which costs $65 - $390 and takes 4h 36m.

Where does the Mayo Clinic to Des Moines bus arrive?

Mayo Clinic to Des Moines bus services, operated by Jefferson Lines, arrive at St. Paul station.

Can I drive from Mayo Clinic to Des Moines?

Yes, the driving distance between Mayo Clinic to Des Moines is 209 miles. It takes approximately 3h 27m to drive from Mayo Clinic to Des Moines.

Where can I stay near Des Moines?

There are 238+ hotels available in Des Moines.

Mayo Clinic to Des Moines - 6 ways to travel via bus, car, and plane

How to get fromMayo Clinic to Des Moines

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There are 6 ways to get from Mayo Clinic to Des Moines by bus (Greyhound), car, plane, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

Bus
best
1. Take the bus from Rochester to St. Paulbus Jefferson Lines 966
2. Take the bus from Saint Paul Union Depot to Des Moinesbus Greyhound US0156
7h 8m
$74–109
Drive 207.3 mi
cheapest
1. Drive from Mayo Clinic to Des Moinescar 207.3 mi
3h 27m
$37–53
Fly from Rochester
1. Fly from Rochester (RST) to Des Moines (DSM)plane RST - DSM
4h 36m
$69–390
Bus via Des Moines
1. Take the bus from Rochester to St. Paulbus Jefferson Lines 966
2. Take the bus from St. Paul to Des Moinesbus Jefferson Lines 805
7h 33m
$94–129
Bus via Minneapolis Airport (MSP)
1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus Groome Transportation
2. Take the bus from Minneapolis-St. Paul to Des Moinesbus Jefferson Lines 803
7h 57m
$115–140
Bus to Minneapolis–Saint Paul International Airport, fly
1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus
2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Des Moines (DSM)plane MSP - DSM
3h 52m
$123–453

Mayo Clinic to Des Moines by foot and bus

7Weekly Services

7h 8mAverage Duration

$74Cheapest Price

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Comparing Your Travel Options

Map of how to get from Mayo Clinic to Des Moines.

Launch map view

Distance: 322.7 mi
Duration: 7h 8m

What companies run services between Mayo Clinic, MN, USA and Des Moines, IA, USA?

You can take a vehicle from Mayo Clinic to Des Moines via Rochester and Saint Paul Union Depot in around 7h 8m. Alternatively, Delta and American Airlines fly from Rochester (RST) to Des Moines (DSM) 5 times a day.

Airlines

Bus operators

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