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How to get fromMayo Clinic to Destinby plane, bus, taxi, train, or car

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There are 10 ways to get from Mayo Clinic to Destin by plane, bus, taxi, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Rochester to Destin–Fort Walton Beach Airport

    best
    1. Fly from Rochester (RST) to Destin–Fort Walton Beach Airport (VPS)plane plane RST - VPS
    6h 52m
    $136–562

  2. Bus, taxi

    1. Take the bus from Rochester to Milwaukeebus bus
    2. Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Atlanta Bus Stationbus bus
    4. Take the bus from Atlanta Bus Station to La Grange Bus Stationbus bus
    5. Take the bus from La Grange Bus Station to Mobilebus bus
    6. Take the bus from Loxley to Crestviewbus bus
    7. Take the taxi from Crestview to Destintaxi taxi
    35h 21m
    $383–559

  3. Bus, train, taxi via Madison

    1. Take the bus from Rochester to Madisonbus bus
    2. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus
    3. Take the train from Chicago Union Station to New Orleans Union Passenger Terminaltrain train
    4. Take the train from New Orleans Union Passenger Terminal to Pascagoulatrain train
    5. Take the bus from Pascagoula to Crestviewbus bus
    6. Take the taxi from Crestview to Destintaxi taxi
    36h 52m
    $464–914

  4. Drive  1,172.6 mi

    1. Drive from Mayo Clinic to Destincar car 1,172.6 mi
    21h 3m
    $214–310

  5. Bus to Minneapolis–Saint Paul International Airport, fly to Destin–Fort Walton Beach Airport

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Destin–Fort Walton Beach Airport (VPS)plane plane MSP - VPS
    5h 31m
    $200–705

  6. Fly Rochester to Northwest Florida Beaches International Airport, taxi

    1. Fly from Rochester (RST) to Northwest Florida Beaches International Airport (ECP)plane plane RST - ECP
    2. Take the taxi from Northwest Florida Beaches International Airport (ECP) to Destintaxi taxi
    9h 35m
    $236–697

  7. Fly Rochester to Pensacola International Airport, taxi

    1. Fly from Rochester (RST) to Pensacola International Airport (PNS)plane plane RST - PNS
    2. Take the taxi from Pensacola-Airport-PNS to Destintaxi taxi
    9h 54m
    $196–577

  8. Bus to Minneapolis–Saint Paul International Airport, fly to Northwest Florida Beaches International Airport, taxi

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Northwest Florida Beaches International Airport (ECP)plane plane MSP - ECP
    3. Take the taxi from Northwest Florida Beaches International Airport (ECP) to Destintaxi taxi
    8h 1m
    $300–830

  9. Bus, train, taxi

    1. Take the bus from Rochester to St. Paulbus bus
    2. Take the train from St. Paul-Minneapolis to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to New Orleans Union Passenger Terminaltrain train
    4. Take the train from New Orleans Union Passenger Terminal to Pascagoulatrain train
    5. Take the bus from Pascagoula to Crestviewbus bus
    6. Take the taxi from Crestview to Destintaxi taxi
    38h 3m
    $513–1,059

  10. Bus, taxi via Indianapolis

    1. Take the bus from Rochester to Madisonbus bus
    2. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus
    3. Take the bus from Chicago Union Station to Indianapolis Union Stationbus bus
    4. Take the bus from Indianapolis Union Station to Montgomery Intermodal Centerbus bus
    5. Take the bus from Montgomery Intermodal Center to Biloxi Transit Centerbus bus
    6. Take the bus from Biloxi to Crestviewbus bus
    7. Take the taxi from Crestview to Destintaxi taxi
    38h 44m
    $374–564

Rochester (RST) to Destin–Fort Walton Beach Airport (VPS) flights

Calendar11Weekly Planes
Duration5h 58mAverage Duration
Ticket$95Cheapest Price
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Comparing Your Travel Options

Map of how to get from Mayo Clinic to Destin.ExpandLaunch map view
  • Distance: 1,007 mi
  • Duration: 6h 52m

What companies run services between Mayo Clinic, MN, USA and Destin, FL, USA?

American Airlines, Delta, and Sun Country Airlines fly from Rochester (RST) to Destin–Fort Walton Beach Airport (VPS) twice daily.

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