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How to get fromMayo Clinic to Destinby plane, bus, taxi, train, or car

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There are 9 ways to get from Mayo Clinic to Destin by plane, bus, taxi, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Rochester to Destin–Fort Walton Beach Airport

    best
    1. Fly from Rochester (RST) to Destin–Fort Walton Beach Airport (VPS)plane plane RST - VPS
    7h 19m
    $255–975

  2. Bus to Minneapolis–Saint Paul International Airport, fly to Destin–Fort Walton Beach Airport

    cheapest
    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Destin–Fort Walton Beach Airport (VPS)plane plane MSP - VPS
    5h 29m
    $200–655

  3. Bus, taxi

    1. Take the bus from Rochester, MN to UW-Madisonbus bus
    2. Take the bus from Madison to Indianapolisbus bus
    3. Take the bus from Indianapolis Union Station to Montgomery Intermodal Centerbus bus
    4. Take the bus from Montgomery Intermodal Center to Mobile Bus Stationbus bus
    5. Take the bus from Mobile to Crestviewbus bus
    6. Take the taxi from Crestview to Destintaxi taxi
    36h 27m
    $408–624

  4. Bus, train, taxi via Madison

    1. Take the bus from Rochester, MN to UW-Madisonbus bus
    2. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus
    3. Take the train from Chicago Union Station to New Orleans Union Passenger Terminaltrain train
    4. Take the train from New Orleans Union Passenger Terminal to Gulfport Amtrak Statrain train
    5. Take the bus from Gulfport to Crestviewbus bus
    6. Take the taxi from Crestview to Destintaxi taxi
    36h 44m
    $540–1,009

  5. Drive 1,172.6 mi

    1. Drive from Mayo Clinic to Destincar car 1,172.6 mi
    21h 3m
    $214–310

  6. Bus to Minneapolis–Saint Paul International Airport, fly to Northwest Florida Beaches International Airport, taxi

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Northwest Florida Beaches International Airport (ECP)plane plane MSP - ECP
    3. Take the taxi from Northwest Florida Beaches International Airport (ECP) to Destintaxi taxi
    7h 58m
    $310–780

  7. Fly Rochester to Northwest Florida Beaches International Airport, taxi

    1. Fly from Rochester (RST) to Northwest Florida Beaches International Airport (ECP)plane plane RST - ECP
    2. Take the taxi from Northwest Florida Beaches International Airport (ECP) to Destintaxi taxi
    9h 39m
    $345–1,100

  8. Fly Rochester to Pensacola International Airport, taxi

    1. Fly from Rochester (RST) to Pensacola International Airport (PNS)plane plane RST - PNS
    2. Take the taxi from Pensacola-Airport-PNS to Destintaxi taxi
    9h 50m
    $305–980

  9. Bus, train, taxi

    1. Take the bus from Rochester to St. Paulbus bus
    2. Take the train from St. Paul-Minneapolis to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to New Orleans Union Passenger Terminaltrain train
    4. Take the train from New Orleans Union Passenger Terminal to Mobile Amtrak Statrain train
    5. Take the bus from Mobile to Crestviewbus bus
    6. Take the taxi from Crestview to Destintaxi taxi
    38h
    $614–1,214

Rochester (RST) to Destin–Fort Walton Beach Airport (VPS) flights

Calendar11Weekly Planes
Duration6h 34mAverage Duration
Ticket$200Cheapest Price
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Questions & Answers

Map of how to get from Mayo Clinic to Destin.ExpandLaunch map view
  • Distance: 1,007 mi
  • Duration: 7h 19m

What companies run services between Mayo Clinic, MN, USA and Destin, FL, USA?

Delta and Sun Country Airlines fly from Rochester (RST) to Destin–Fort Walton Beach Airport (VPS) twice daily.

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